Normalising the Implementation of Pharmacogenomic (PGx) Testing in Adult Mental Health Settings: A Theory-Based Systematic Review
Rattachement africain : gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Pharmacogenomic (PGx) testing can help personalise psychiatric prescribing and improve on the currently adopted trial-and-error prescribing approach. However, widespread implementation is yet to occur. Understanding factors influencing implementation is pertinent to the psychiatric PGx field. Normalisation Process Theory (NPT) seeks to understand the work involved during intervention implementation and is used by this review (PROSPERO: CRD42023399926) to explore factors influencing PGx implementation in psychiatry. Four databases were systematically searched for relevant records and assessed for eligibility following PRISMA guidance. The QuADS tool was applied during quality assessment of included records. Using an abductive approach to codebook thematic analysis, barrier and facilitator themes were developed using NPT as a theoretical framework. Twenty-nine records were included in the data synthesis. Key barrier themes included a PGx knowledge gap, a lack of consensus in policy and guidance, and uncertainty towards the use of PGx. Facilitator themes included an interest in PGx use as a new and improved approach to prescribing, a desire for a multidisciplinary approach to PGx implementation, and the importance of fostering a climate for PGx implementation. Using NPT, this novel review systematically summarises the literature in the psychiatric PGx implementation field. The findings highlight a need to develop national policies on using PGx, and an education and training workforce plan for mental health professionals. By understanding factors influencing implementation, the findings help to address the psychiatric PGx implementation gap. This helps move clinical practice closer towards a personalised psychotropic prescribing approach and associated improvements in patient outcomes. Future policy and research should focus on the appraisal of PGx implementation in psychiatry and the role of pharmacists in PGx service design, implementation, and delivery.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Normalising the Implementation of Pharmacogenomic (PGx) Testing in Adult Mental Health Settings: A Theory-Based Systematic Review
- Date Crossref
- 27/09/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
University of Bradford pays non établi dans la noticeUniversité ou école supérieure
-
Bradford District Care NHS Foundation Trust pays non établi dans la noticeOrganisation à but non lucratif
-
University of Hull pays non établi dans la noticeUniversité ou école supérieure
-
Leeds Teaching Hospitals NHS Trust pays non établi dans la noticeÉtablissement de santé
-
Sheffield Hallam University Biomolecular Sciences Research Centre pays non établi dans la noticeUniversité ou école supérieure
-
Newcastle University Population Health Sciences Institute pays non établi dans la noticeUniversité ou école supérieure
-
University of Leeds pays non établi dans la noticeUniversité ou école supérieure
-
School of Pharmacy & Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Wolfson Centre for Applied Health Research pays non établi dans la noticeInstitution
-
Hull University Teaching Hospitals NHS Trust Pharmacy Department pays non établi dans la noticeUniversité ou école supérieure
-
Leeds Teaching Hospitals NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
-
Faculty of Medicine and Health Leeds Institute of Health Sciences pays non établi dans la noticeUniversité ou école supérieure
University of Bradford, Bradford District Care NHS Foundation Trust et University of Hull, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.