Shengqiang Chen

Preservation of chondrocyte microspheroids by local sustained hydrogen supply improves osteoarthritic cartilage repair

Shengqiang Chen, Mingrui Luo, Sizhen Chen, Danyang Chen et autres

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NIR‐II‐Photopyroelectric Catalysis for Immunoactivation/Ferroptosis Combined Therapy of Tumor

Chao Xia, Shengqiang Chen, Xishen Xu, Bin Zhao et autres

Abstract Second near‐infrared (NIR‐II) light is desired to drive photocatalytic therapy owing to its high tissue penetrability and operationality, but the efficiency of direct NIR‐II‐photocatalytic H 2 generation is negligible owing to a trade‐off between narrow semiconductor bandgap and high redox potential. …

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NIR‐II‐Photopyroelectric Catalysis for Immunoactivation/Ferroptosis Combined Therapy of Tumor

Chao Xia, Shengqiang Chen, Xishen Xu, Bin Zhao et autres

Abstract Second near‐infrared (NIR‐II) light is desired to drive photocatalytic therapy owing to its high tissue penetrability and operationality, but the efficiency of direct NIR‐II‐photocatalytic H 2 generation is negligible owing to a trade‐off between narrow semiconductor bandgap and high redox potential. …

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Local sustained H2 release assisted stem cell transplantation for enhanced osteoarthritic cartilage regeneration

Shengqiang Chen, An Shao, Chao Xia, Lingting Zeng et autres

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Status quo, challenges and future directions of hydrogen medicine

Shengqiang Chen, Lingting Zeng, Qianjun He

The hydrogen molecule (H 2 ) has distinctive characteristics and advantages in broad-spectrum anti-inflammation, high biosafety and strong tissue permeability, exhibiting therapeutic potential in numerous diseases associated with inflammation and oxidative stress. In this perspective, we attempt to show a clear picture …

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Recent Progress in Ferroptosis Induced Tumor Cell Death by Anti‐tumor Metallic complexes

Yong‐Chang Zhou, Tian‐Kun Zhao, Si‐Man Tao, Peng Wang et autres

Metal complexes represented by platinum complexes play a very important role in cancer treatment due to their diverse chemical structures and anti-tumor activities. Recently, ferroptosis has emerged as a newly occurring cell death form in the anti-tumor process. It has been reported …

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Local H2 release remodels senescence microenvironment for improved repair of injured bone

Shengqiang Chen, Yuanman Yu, Songqing Xie, Danna Liang et autres

Abstract The senescence microenvironment, which causes persistent inflammation and loss of intrinsic regenerative abilities, is a main obstacle to effective tissue repair in elderly individuals. In this work, we find that local H2 supply can remodel the senescence microenvironment by anti-inflammation and …

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Glutathione/pH-responsive copper-based nanoplatform for amplified chemodynamic therapy through synergistic cycling regeneration of reactive oxygen species and dual glutathione depletion

Sihan Jia, Sunkui Ke, Li Tu, Shengqiang Chen et autres

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Inhibition of free heme-catalyzed Fenton-like reaction prevents non-alcoholic fatty liver disease by hepatocyte-targeted hydrogen delivery

Min Zhao, Zhaokui Jin, Chao Xia, Shengqiang Chen et autres

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Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing

Qingqing Xu, Shengqiang Chen, Lingdong Jiang, Chao Xia et autres

ABSTRACT It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm. H2 is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability. …

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Two‐Dimensional Mg2Si Nanosheet‐Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin

Yanxia Zhu, Qi Jiang, Zhaokui Jin, Danyang Chen et autres

Abstract Molecular hydrogen holds a high potential for wound healing owing to its anti‐inflammatory effect and high biosafety, but commonly used hydrogen administration routes hardly achieve the sustained supply of high‐dosage hydrogen, limiting hydrogen therapy efficacy. Here, two‐dimensional Mg2Si nanosheet (MSN) is …

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Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing

Shengqiang Chen, Yanxia Zhu, Qingqing Xu, Qi Jiang et autres

High-glucose microenvironment in the diabetic foot ulcer (DFU) causes excessive glycation and induces chronic inflammation, leading to the difficulty of DFU healing. Hydrogen-rich water bath can promote the healing of DFU in clinic by virtue of the anti-inflammatory effect of hydrogen molecules, …

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