Zhaokui Jin

Injectable Chito-oligosaccharide-hyaluronic acid hydrogels with Fe3+/AMP nano-enzyme promote ROS scavenging and immunomodulation for myocardial infarction repair

Lin Chen, Sihan Xue, Jinde Zhang, Xiaofei Wen et autres

INTRODUCTION: The post-infarction microenvironment, dominated by oxidative stress, hypoxia, and dysregulated inflammation, severely limits cardiac regeneration. Existing injectable hydrogels for myocardial infarction (MI) rarely address these factors simultaneously, and excessive reactive oxygen species (ROS) scavenging may paradoxically cause oxidative damage. OBJECTIVES: To …

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Inhalable acid-responsive methane nanocapsule for remodeling fibrogenic microenvironment to alleviate idiopathic pulmonary fibrosis

Zhaokui Jin, Xiaoyu Li, Qi Gao, Hantao Wu et autres

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NIR‐II Dual‐Modal Photoacoustic and OCT/OCTA Contrast Mechanisms Imaging Microenvironment Responses for Precision‐Guiding Tumor Photothermal Theranostics

Linhai Yang, Jingchao Li, Shuting Ling, Fengxian Du et autres

Non-invasive, 3D visualization and quantification of dynamic molecular events within the tumor microenvironment are critical for advancing cancer theranostics. However, integrating high-resolution anatomical imaging with functional hemodynamic and vascular assessments remains challenging. Consequently, how photothermal therapy (PTT) differentially influences microenvironmental responses during …

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Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Shuting Ling, Chongxin Wu, Mengxuan Gui, Kai‐Yun Chen et autres

Neurotropic viruses are highly invasive in the central nervous system (CNS) and can disrupt the microcirculation, leading to neurological complications and encephalopathy. Understanding these pathophysiological alterations is crucial for uncovering the underlying mechanisms of viral infection, developing effective vaccines, and creating targeted …

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Hydrogen Medicine Materials

Chao Xia, Lingdong Jiang, Zhaokui Jin, Qianjun He

Conspectus Hydrogen medicine materials are defined as a new concept of biomedical materials specifically engineered to overcome critical challenges in hydrogen medicine, including exploration of biological effects and mechanisms of H 2 by in vivo monitoring of H 2 transportation, metabolism and …

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Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Jiameng Li, Yali Zhang, Zhaokui Jin, Mengliang Zhu et autres

Over centuries of clinical practice, Chinese herbal medicines (CHMs) have gained widespread recognition for their efficacy in treating various diseases. However, their complex material basis and relatively mild therapeutic efficacy limit their modernization and quality control. Recently, the application of pharmaceutical nanotechnology …

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Nanocatalytic medicine: An advanced catalysis-based imaging and therapy methodology

Lingdong Jiang, Zhaokui Jin, Qianjun He

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A Slimming/Excavating Strategy for Enhanced Intratumoral Penetration of Acid‐Disassemblable NO‐Releasing Nanomedicines

Lingdong Jiang, An‐Bang Wu, Lingting Zeng, Bin Zhou et autres

Poor tumor penetration is the major predicament of nanomedicines that limits their anticancer efficacy. The dense extracellular matrix (ECM) in the tumor is one of the major barriers against the deep penetration of nanomedicines. In this work, a slimming/excavating strategy is proposed …

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Multiscale Imaging Reveals Cerebral Microcirculation Dysfunction And Mechanisms in Pseudorabies Virus Infections

Shuting Ling, Chongxin Wu, Mengxuan Gui, Kai‐Yun Chen et autres

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Ascorbate/methionine-based CH4 delivery nanomedicine for tumor-targeted therapy

Xiaoyu Li, Chao Xia, Zhaokui Jin, Qianjun He

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Nanoscale synthetic biology with innovative medicinal applications

Jingsen Ji, Li Li, Weisheng Guo, Yuying Yao et autres

The rapid advancement of synthetic biology and nanoscience has given rise to a new research field, known as nanoscale synthetic biology (NSB). This field emphasizes the interactions and coordination within entire biological systems, with the goal of achieving more efficient and controllable …

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Novel two-dimensional FeB nanosheets for photoacoustic imaging-guided NIR-photothermal therapy

Danyang Chen, Yingshuai Wang, Penghe Zhao, Zhaokui Jin et autres

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