Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
High-glucose microenvironment in the diabetic foot ulcer (DFU) causes excessive glycation and induces chronic inflammation, leading to the difficulty of DFU healing. Hydrogen-rich water bath can promote the healing of DFU in clinic by virtue of the anti-inflammatory effect of hydrogen molecules, but the long-term daily soaking counts against the formation of a scab and cannot change the high-glucose microenvironment, limiting the outcome of DFU therapy. In this work, photocatalytic therapy of diabetic wound is proposed for sustainable hydrogen generation and local glucose depletion by utilizing glucose in the high-glucose microenvironment as a sacrificial agent. Hydrogen-incorporated titanium oxide nanorods are developed to realize efficient visible light (VIS)-responsive photocatalysis for glucose depletion and hydrogen generation, achieving a high efficacy of diabetic wound healing. Mechanistically, local glucose depletion and hydrogen generation jointly attenuate the apoptosis of skin cells and promote their proliferation and migration by inhibiting the synthesis of advanced glycation end products and the expression of their receptors, respectively. The proposed VIS-photocatalytic strategy provides a solution for facile, safe and efficient treatment of DFU.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing
- Date Crossref
- 27/09/2022
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Shenzhen University Health Science Center pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Jiao Tong University Shenzhen Research Institute pays non établi dans la noticeUniversité ou école supérieure
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School of Biomedical Engineering Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging pays non établi dans la noticeUniversité ou école supérieure
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School of Basic Medical Sciences Department of Cell Biology and Medical Genetics pays non établi dans la noticeUniversité ou école supérieure
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School of Materials Science and Engineering Shanghai Key Laboratory of Hydrogen Science & Shanghai Key Laboratory of Hydrogen Science & Center of Hydrogen Science pays non établi dans la noticeUniversité ou école supérieure
Shenzhen University Health Science Center, Shenzhen Research Institute — Shanghai Jiao Tong University et Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging — School of Biomedical Engineering, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.