Accès ouvert
2025
article
OpenAlex
Sohvi Ohtonen, Henna Jäntti, Luca Giudice, Ahmed Y. Mohamed et autres
Exposure to air pollution is associated with neurological diseases. Traffic is a major source of air pollution, consisting of a complex mixture of ultrafine particles, that can invade the brain and induce a microglia-mediated inflammatory response. However, the exact mechanisms of how …
fi, cz, nl, it
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Accès ouvert
2024
article
OpenAlex
Flavia Scoyni, Valeriia Sitnikova, Luca Giudice, Paula Korhonen et autres
Brain functionality relies on finely tuned regulation of gene expression by networks of non-coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known as CDR1as), the microRNA miR-7, and the long ncRNA Cyrano. We describe ischemia-induced alterations …
fi, se, dk, ch, de, us, pl
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Accès ouvert
2024
article
OpenAlex
Henna Jäntti, Steffi M Jonk, Mireia Gómez‐Budia, Sohvi Ohtonen et autres
Abstract Background Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence of neurodegenerative diseases such as Alzheimer’s disease. Inhaled components of PM may …
us, fi, se, au
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Accès ouvert
2023
article
OpenAlex
Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen et autres
LRRK2-G2019S is one of the most common Parkinson's disease (PD)-associated mutations and has been shown to alter microglial functionality. However, the impact of LRRK2-G2019S on transcriptional profile of human induced pluripotent stem cell-derived microglia-like cells (iMGLs) and how it corresponds to microglia …
fi, us, no, se
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Accès ouvert
2023
article
OpenAlex
Flavia Scoyni, Luca Giudice, Mari‐Anna Väänänen, Nicholas L. Downes et autres
INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disease and the main cause of dementia in the elderly. AD pathology is characterized by accumulation of microglia around the beta-amyloid (Aβ) plaques which assumes disease-specific transcriptional signatures, as for the disease-associated microglia (DAM). However, …
fi, au, nl, dk
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Accès ouvert
2023
article
OpenAlex
Jie Liu, Heleen v Beusekom, Xian‐Le Bu, Gong Chen et autres
The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease (AD) and associated socioeconomic burdens. Abnormal metabolism of amyloid-β (Aβ) has been proposed as a significant pathomechanism in AD, supported by results of recent clinical …
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Accès ouvert
2023
article
OpenAlex
Larisa Chernyaeva, Giorgio Ratti, Laura Teirilä, Satoshi Fudo et autres
The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele associated with late-onset Alzheimer's disease (AD). ApoE interacts with complement regulator factor H (FH), but the role of this interaction in AD pathogenesis is unknown. Here we elucidate …
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Accès ouvert
2023
preprint
OpenAlex
Flavia Scoyni, Valeriia Sitnikova, Luca Giudice, Paula Korhonen et autres
ABSTRACT Brain functionality relies on finely tuned regulation of gene expression by networks of non-coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known as CDR1as), the microRNA miR-7 and the long non-coding RNA Cyrano. Here we …
fi, se, dk, ch, de, us, pl, no
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Accès ouvert
2023
article
OpenAlex
Nea Korvenlaita, Mireia Gómez‐Budia, Flavia Scoyni, Cristiana Pistono et autres
Hypoxia induces changes in the secretion of extracellular vesicles (EVs) in several non-neuronal cells and pathological conditions. EVs are packed with biomolecules, such as microRNA(miR)-21-5p, which respond to hypoxia. However, the true EV association of miR-21-5p, and its functional or biomarker relevance, …
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2022
article
OpenAlex
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Ali K. J. Koskela et autres
Abstract Purpose: Chronic oxidative stress, disturbed proteostasis and increased protein aggregation are key hallmarks in Alzheimer's disease and age‐related macular degeneration pathology. In this study, we assessed the protein aggregation and secretory autophagy related biomarker changes in 5xFAD mice model expressing abundant …
fi
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Accès ouvert
2022
article
OpenAlex
Mikko Gynther, Mariana Leal Estrada, Sanna H. Loppi, Paula Korhonen et autres
Cytosolic phospholipase A2 (cPLA2) is an enzyme regulating membrane phospholipid homeostasis and the release of arachidonic acid utilized in inflammatory responses. It represents an attractive target for the treatment of Alzheimer's disease (AD). Previously, we showed that lipopolysaccharide (LPS)-induced systemic inflammation caused …
de, us, fi
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Accès ouvert
2022
article
OpenAlex
Henna Jäntti, Valeriia Sitnikova, Yevheniia Ishchenko, Anastasia Shakirzyanova et autres
BACKGROUND: Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's disease (AD), toxic amyloid beta (Aβ) accumulates in the brain and forms stiff plaques. In late-onset …
fi, us, it, au
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