Mari‐Anna Väänänen

Investigating the Intracellular Compartmental Dynamics of miRNAs in Response to Hypoxia

Vanesa Tomas Bosch, Pierre R. Moreau, Pia Laitinen, Mari‐Anna Väänänen et autres

Abstract MicroRNAs (miRNAs) are a class of small non-coding RNAs (ncRNAs) with established functions in cytoplasmic gene regulation, where they interact with mRNA transcripts, impeding their translation—a process known as post-transcriptional gene silencing (PTGS). Recent studies have found that miRNAs and other …

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Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia

Sohvi Ohtonen, Henna Jäntti, Luca Giudice, Ahmed Mohamed et autres

Exposure to air pollution is associated with neurological diseases. Traffic is a major source of air pollution, consisting of a complex mixture of ultrafine particles, that can invade the brain and induce a microglia-mediated inflammatory response. However, the exact mechanisms of how …

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The critical role of isomiRs in accurate differential expression analysis of miRNA-seq data

Eloi Schmauch, Yassine Attia, Pia Laitinen, Tiia A. Turunen et autres

Abstract MicroRNAs (miRNAs) are crucial for the regulation of gene expression and are promising biomarkers and therapeutic targets. miRNA isoforms (isomiRs) differ in their start/end offsets, which can impact the target gene selection and non-canonical function of the miRNA species. In addition, …

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Alzheimer's disease‐induced phagocytic microglia express a specific profile of coding and non‐coding RNAs

Flavia Scoyni, Luca Giudice, Mari‐Anna Väänänen, Nicholas Downes et autres

INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disease and the main cause of dementia in the elderly. AD pathology is characterized by accumulation of microglia around the beta-amyloid (Aβ) plaques which assumes disease-specific transcriptional signatures, as for the disease-associated microglia (DAM). However, …

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Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription

Nicholas Downes, Henri Niskanen, Vanesa Tomas Bosch, Mari Taipale et autres

Impaired oxygen homeostasis is a frequently encountered pathophysiological factor in multiple complex diseases, including cardiovascular disease and cancer. While the canonical hypoxia response pathway is well characterized, less is known about the role of noncoding RNAs in this process. Here, we investigated …

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Construction of Fusion Protein for Enhanced Small RNA Loading to Extracellular Vesicles

Masoumeh Es-Haghi, Olga Neustroeva, Iftekhar Chowdhury, Pia Laitinen et autres

Extracellular vesicles (EVs) naturally carry cargo from producer cells, such as RNA and protein, and can transfer these messengers to other cells and tissue. This ability provides an interesting opportunity for using EVs as delivery vehicles for therapeutic agents, such as for …

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Nuclear microRNA-466c regulates Vegfa expression in response to hypoxia

Pia Laitinen, Mari‐Anna Väänänen, Ida-Liisa Kolari, Petri I. Mäkinen et autres

MicroRNAs are well characterized in their role in silencing gene expression by targeting 3´-UTR of mRNAs in cytoplasm. However, recent studies have shown that miRNAs have a role in the regulation of genes in the nucleus, where they are abundantly located. We …

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isomiRs-specific differential expression is the rule, not the exception: Are we missing hundreds of species in microRNA analysis?

Eloi Schmauch, Pia Laitinen, Tiia A. Turunen, Mari‐Anna Väänänen et autres

ABSTRACT MicroRNAs (miRNAs) are small RNA molecules that act as regulators of gene expression through targeted mRNA degradation. They are involved in many biological and pathophysiological processes and are widely studied as potential biomarkers and therapeutics agents for human diseases, including cardiovascular …

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Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress

Tiia A. Turunen, Thomas C. Roberts, Pia Laitinen, Mari‐Anna Väänänen et autres

MicroRNAs (miRNAs) are small non-coding RNAs that have well-characterized roles in cytoplasmic gene regulation, where they act by binding to mRNA transcripts and inhibiting their translation (i.e. post-transcriptional gene silencing, PTGS). However, miRNAs have also been implicated in transcriptional gene regulation and …

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Epigenomics

Tiia A. Turunen, Mari‐Anna Väänänen, Seppo Ylä‐Herttuala

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Inhibition of mouse microRNA 669c-5p using a sponge construct

Mari‐Anna Väänänen

Nuclear miRNAs mmu-miR-466/699, SFMBT2, YY1 and HIF1 alpha in the regulation of VEGF-A expression

Pia Laitinen, Tiia Husso, Ida-Liisa Kolari, Mari‐Anna Väänänen et autres