Accès ouvert
2026
article
OpenAlex
Nea Korvenlaita, Mireia Gómez‐Budia, Cristiana Pistono, Flavia Scoyni et autres
Abstract Ischemic stroke triggers a rapid immune infiltration to the brain, reshaping its cell type composition and possibly confounding the analysis of immune cell enriched molecules. MicroRNAs (miRNAs) act as powerful regulators by fine-tuning messenger RNA (mRNA) expression, thereby modulating cell type …
fi, de, es, cz
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2024
article
OpenAlex
Salli Antila, Dmitri Chilov, Harri J. Nurmi, Zhilin Li et autres
Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs (dLVs) that depend on vascular endothelial growth factor C expression, has raised interest in their possible involvement in Alzheimer's disease (AD). Here we find that in the …
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2024
article
OpenAlex
Flavia Scoyni, Valeriia Sitnikova, Luca Giudice, Paula Korhonen et autres
Brain functionality relies on finely tuned regulation of gene expression by networks of non-coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known as CDR1as), the microRNA miR-7, and the long ncRNA Cyrano. We describe ischemia-induced alterations …
fi, se, dk, ch, de, us, pl
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Accès ouvert
2023
article
OpenAlex
Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen et autres
LRRK2-G2019S is one of the most common Parkinson's disease (PD)-associated mutations and has been shown to alter microglial functionality. However, the impact of LRRK2-G2019S on transcriptional profile of human induced pluripotent stem cell-derived microglia-like cells (iMGLs) and how it corresponds to microglia …
fi, us, no, se
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2023
article
OpenAlex
Flavia Scoyni, Luca Giudice, Mari‐Anna Väänänen, Nicholas L. Downes et autres
INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disease and the main cause of dementia in the elderly. AD pathology is characterized by accumulation of microglia around the beta-amyloid (Aβ) plaques which assumes disease-specific transcriptional signatures, as for the disease-associated microglia (DAM). However, …
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Accès ouvert
2023
preprint
OpenAlex
Flavia Scoyni, Valeriia Sitnikova, Luca Giudice, Paula Korhonen et autres
ABSTRACT Brain functionality relies on finely tuned regulation of gene expression by networks of non-coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known as CDR1as), the microRNA miR-7 and the long non-coding RNA Cyrano. Here we …
fi, se, dk, ch, de, us, pl, no
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Accès ouvert
2023
article
OpenAlex
Masoumeh Es-Haghi, Olga Neustroeva, Iftekhar Chowdhury, Pia Laitinen et autres
Extracellular vesicles (EVs) naturally carry cargo from producer cells, such as RNA and protein, and can transfer these messengers to other cells and tissue. This ability provides an interesting opportunity for using EVs as delivery vehicles for therapeutic agents, such as for …
fi
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Accès ouvert
2023
article
OpenAlex
Nea Korvenlaita, Mireia Gómez‐Budia, Flavia Scoyni, Cristiana Pistono et autres
Hypoxia induces changes in the secretion of extracellular vesicles (EVs) in several non-neuronal cells and pathological conditions. EVs are packed with biomolecules, such as microRNA(miR)-21-5p, which respond to hypoxia. However, the true EV association of miR-21-5p, and its functional or biomarker relevance, …
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2022
article
OpenAlex
Nea Korvenlaita, Lauri M. Louhivuori
An increasing amount of evidence points to an important role of macrophages in peripheral nerve injury (PNI) and associated pain. Peripheral nerve macrophages facilitate the regeneration, while dorsal root ganglia (DRG) macrophages might propagate the injury after a PNI. These differences might …
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Accès ouvert
2022
article
OpenAlex
Henna Jäntti, Valeriia Sitnikova, Yevheniia Ishchenko, Anastasia Shakirzyanova et autres
BACKGROUND: Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's disease (AD), toxic amyloid beta (Aβ) accumulates in the brain and forms stiff plaques. In late-onset …
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Accès ouvert
2022
preprint
OpenAlex
Henna Konttinen, Valeria Sitnikova, Yevheniia Ishchenko, Anastasia Shakirzyanova et autres
ABSTRACT Background Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer’s disease (AD), toxic amyloid beta (Aβ) accumulates in the brain and forms stiff plaques. In …
fi, us, it, au
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