Laura Teirilä

Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation

Larisa Chernyaeva, Giorgio Ratti, Laura Teirilä, Satoshi Fudo et autres

The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele associated with late-onset Alzheimer's disease (AD). ApoE interacts with complement regulator factor H (FH), but the role of this interaction in AD pathogenesis is unknown. Here we elucidate …

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Reduced Binding of Apolipoprotein E4 Isoform to Complement Factor H Promotes Amyloid-Β Induced Neuroinflammation in vitro and in vivo

Larisa Chernyaeva, Giorgio Ratti, Laura Teirilä, Uni Rankka et autres

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Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre‐eclampsia: a genetic and functional study

Anna Inkeri Lokki, Laura Teirilä, Michael P. Triebwasser, Eoin Daly et autres

OBJECTIVE: To study genetic variants and their function within genes coding for complement receptors in pre-eclampsia. DESIGN: A case-control study. SETTING: Pre-eclampsia is a common vascular disease of pregnancy. The clearance of placenta-derived material is one of the functions of the complement …

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Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study

Anna Inkeri Lokki, Laura Teirilä, Michael P. Triebwasser, Eoin Daly et autres

Regulation of the complement system and immunological tolerance in pregnancy

Laura Teirilä, Jenni Heikkinen‐Eloranta, Juha P. Kotimaa, Seppo Meri et autres

Preeclampsia is a serious vascular complication of the human pregnancy, whose etiology is still poorly understood. In preeclampsia, exacerbated apoptosis and fragmentation of the placental tissue occurs due to developmental qualities of the placental trophoblast cells and/or mechanical and oxidative distress to …

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Activation of the Inflammatory Response by Fungal Components

Laura Teirilä

Fungi are associated with a wide range of diseases from superficial skin syndromes to invasive life-threating conditions. Furthermore, exposure to non-infectious fungal components in the context of agricultural work or in water-damaged houses has been associated to illnesses in the respiratory tract. …

Proteomic Changes of Alveolar Lining Fluid in Illnesses Associated with Exposure to Inhaled Non-Infectious Microbial Particles

Laura Teirilä, Kirsi Karvala, Niina Ahonen, Henrik Riska et autres

BACKGROUND: Hyperresponsiveness to inhaled non-infectious microbial particles (NIMPs) has been associated with illnesses in the airways. Hypersensitivity pneumonitis (HP) is considered to be the prototype for these NIMPs-related diseases; however, there is no consensus on the definitions or diagnostic criteria for HP …

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Dectin-1 Pathway Activates Robust Autophagy-Dependent Unconventional Protein Secretion in Human Macrophages

Tiina Öhman, Laura Teirilä, Anna‐Maria Lahesmaa‐Korpinen, Wojciech Cypryk et autres

Dectin-1 is a membrane-bound pattern recognition receptor for β-glucans, which are the main constituents of fungal cell walls. Detection of β-glucans by dectin-1 triggers an effective innate immune response. In this study, we have used a systems biology approach to provide the …

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Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

Katri Niemi, Laura Teirilä, Jani Lappalainen, Kristiina Rajamäki et autres

Serum amyloid A (SAA) is an acute-phase protein, the serum levels of which can increase up to 1000-fold during inflammation. SAA has a pathogenic role in amyloid A-type amyloidosis, and increased serum levels of SAA correlate with the risk for cardiovascular diseases. …

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(1,3)-β-Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages

Päivi Kankkunen, Laura Teirilä, Johanna Rintahaka, Harri Tapio Alenius et autres

beta-Glucans are naturally occurring polysaccharides that are the major cell wall components of fungi. Recognition of beta-glucans is mediated through a membrane-bound pattern recognition receptor called dectin-1, and gene knock-out studies have shown that dectin-1 plays an important role in antifungal immune …

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An outbreak of pneumonia associated with S. pneumoniae at a military training facility in Finland in 2006.

Anni Vainio, Outi Lyytikäinen, Reetta Sihvonen, Tarja Kaijalainen et autres

Streptococcus pneumoniae is a well-known cause of community-acquired bacterial pneumonia. The purpose of this study was to assess the cause and extent of the outbreak of pneumonia which occurred among military recruits following a 1-week hard encampment in Finland. We also assessed …

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An outbreak of pneumonia associated with S. pneumoniae at a military training facility in Finland in 2006

Anni Vainio, Outi Lyytikäinen, Reetta Sihvonen, Tarja Kaijalainen et autres

Streptococcus pneumoniae is a well‐known cause of community‐acquired bacterial pneumonia. The purpose of this study was to assess the cause and extent of the outbreak of pneumonia which occurred among military recruits following a 1‐week hard encampment in Finland. We also assessed …

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