Diane Hopkins

The Contribution of BMI to a Young Child’s Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2

Jaakko J. Koskenniemi, Joanna Clasen, Lu You, Hemang Parikh et autres

OBJECTIVE: Childhood obesity may impact the risk of islet autoimmunity (IA). The trajectory of BMI through childhood resembles the early peak incidence of first-appearing autoantibodies against insulin (IAA-first) but not GAD65 (GADA-first). We studied whether a child's BMI can impact the age-related …

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Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study

Marian Rewers, Daniel Agardh, Suzanne Bennett Johnson, Ezio Bonifacio et autres

In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk for many chronic …

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Early Appearance of Thyroid Autoimmunity in Children Followed From Birth for Type 1 Diabetes Risk

Joanna Clasen, Kendra Vehik, Åke Lernmark, Markus Lundgren et autres

CONTEXT: Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define preclinical autoimmune thyroid disease (AITD), which can progress to either clinical hypothyroidism or hyperthyroidism. OBJECTIVE: We determined the age at seroconversion in children genetically at risk for type 1 diabetes. METHODS: TPOAb …

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Structures and Strategies for Retaining an International Pediatric Cohort from Birth: Lessons from The Environmental Determinants of Diabetes in the Young (TEDDY) Study

Patricia Gesualdo, Jessica Melin, Rachel Karban, Claire Cowen Crouch et autres

Background: Retention of study participants in observational studies is essential to maintaining the representativeness of the population, minimizing selection bias, and assuring sufficient statistical power. The aim of this report is to describe the structures and strategies used to retain participants in …

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A candidate panel of eight urinary proteins shows potential of early diagnosis and risk assessment for diabetic kidney disease in type 1 diabetes

Jeremy Altman, Shan Bai, Sharad Purohit, John White et autres

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Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study

Leena Hakola, Lazarus K. Mramba, Ulla Uusitalo, Carin Andrén Aronsson et autres

PURPOSE: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years. METHODS: We followed 8500 T1D-susceptible children …

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Ovarian recurrence risk assessment using machine learning, clinical information, and serum protein levels to predict survival in high grade ovarian cancer

David Mysona, Sharad Purohit, Katherine P. Richardson, Jessa Suhner et autres

In ovarian cancer, there is no current method to accurately predict recurrence after a complete response to chemotherapy. Here, we develop a machine learning risk score using serum proteomics for the prediction of early recurrence of ovarian cancer after initial treatment. The …

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High serum levels of inflammatory markers are associated with early recurrence in patients with high-grade serous ovarian cancer after platinum therapy

Bogna Brzezinska, David Mysona, Katherine P. Richardson, Bunja Rungruang et autres

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Multiplex analysis of inflammatory proteins associated with risk of coronary artery disease in type‐1 diabetes patients

C. H. Beatty, Katherine P. Richardson, Paul Tran, Khaled Bin Satter et autres

Abstract Background Chronic uncontrolled hyperglycemia, a precursor to chronic low‐grade inflammation, is a leading cause of coronary artery disease (CAD) due to plaque buildup in type‐1 diabetes (T1D) patients. We evaluated levels of 22 inflammatory markers in cross‐sectional serum samples from 1222 …

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Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study

Maria Lönnrot, Kristian Lynch, Marian Rewers, Åke Lernmark et autres

OBJECTIVE: To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort. RESEARCH DESIGN AND METHODS: GIEs on risk of autoantibodies against either insulin (IAA) or GAD (GADA) …

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Ovarian Recurrence risk Assessment using Clinical and serum protein LEvels (ORACLE): A Machine Learning Risk Score to Predict Survival in High Grade Ovarian Cancer

David Mysona, Sharad Purohit, Katherine P. Richardson, Jessa Suhner et autres

Abstract In ovarian cancer, there is no current method to accurately predict recurrence after a complete response to chemotherapy. Here, we develop a machine learning risk score using serum proteomics for prediction of early recurrence of ovarian cancer after initial treatment. The …

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Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study

Xiang Liu, Suzanne Bennett Johnson, Kristian Lynch, Kerry Cordan et autres

OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years. RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of Diabetes in the Young …

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