Accès ouvert déclaré
2023
article
Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study
Maria Lönnrot, Kristian Lynch, Marian Rewers, Åke Lernmark, Kendra Vehik, Beena Akolkar, William Hagopian, Jeffrey P. Krischer, Rickhard A. McIndoe, Jorma Toppari, Anette‐G. Ziegler, Joseph F. Petrosino, Richard E. Lloyd, Heikki Hyöty, Kimberly Bautista, Judith Baxter, Daniel Felipe-Morales, Brigitte I. Frohnert, Marisa Stahl, Isabel Flores Garcia, Patricia Gesualdo, Sierra Hays, Michelle Hoffman, Rachel Karban, Edwin Liu, Leila Loaiza, Jill M. Norris, Holly O’Donnell, Loana Thorndahl, Andrea K. Steck, Kathleen Waugh, Olli Simell, Annika Adamsson, Suvi Ahonen, Iris Erlund, Sirpa Anttila, Leena Hakola, Anne Hekkala, Tiia Honkanen, Jorma Ilonen, Sanna Jokipuu, Taru Karjalainen, Leena Eklund Karlsson, Jukka Kero, Jaakko J. Koskenniemi, Miia Kähönen, Mikael Knip, Minna-Liisa Koivikko, Katja Kokkonen, Merja Koskinen, Mirva Koreasalo, Kalle Kurppa, Salla Kuusela, Jarita Kytölä, Jutta E. Laiho, Tiina Latva-aho, Siiri Leisku, Laura Leppänen, Katri Lindfors, Elina Mäntymäki, Markus Mattila, Maija E. Miettinen, Teija Mykkänen, Tiina Niininen, Sari Niisistö, Noora Nurminen, Sami Oikarinen, Hanna-Leena Oinas, Paula Ollikainen, Zhian Othmani, Sirpa Pohjola, Solja Raja-Hanhela, Jenna Rautanen, Anne Riikonen, Minna Romo, Juulia Rönkä, Nelli Rönkä, Satu Simell, Päivi Tossavainen, Mari Vähä-Mäkilä, Eeva Varjonen, Riitta Veijola, Irene Viinikangas, Silja Vilmi, Suvi Μ. Virtanen, Richard McIndoe, Desmond Schatz, Diane Hopkins, Michael J. Haller, Risa Bernard, Melissa Gardiner, Ashok Sharma, Laura M. Jacobsen, Jennifer Hosford, Kennedy Petty, Leah Schust Myers, Chelsea Salmon, Anette G. Ziegler, Ezio Bonifacio, Cigdem Gezginci, Willi Grätz, Anja Heublein, Eva Hohoff, Sandra Hummel, Annette Knopff, Melanie Köger, Sibylle Koletzko, Claudia Ramminger, Roswith Roth, Jennifer Schmidt, Marlon Scholz, Joanna Stock, Katharina Warncke, Lorena Wendel, Christiane Winkler, Daniel Agardh, Carin Andrén Aronsson, Rasmus Bennet, Corrado Cilio, Susanne Dahlberg, Ulla Fält, Malin Goldman Tsubarah, Emelie Ericson-Hallström, Lina Fransson, Emina Halilovic, Gunilla Holmén, Susanne Hyberg, Berglind Jónsdóttir, Naghmeh Karimi, Helena Elding Larsson, Marielle Lindström, Markus Lundgren, Marlena Maziarz, Jessica Melin, Caroline Nilsson, Kobra Rahmati, Anita Ramelius, Falastin Salami, Anette Sjöberg, Evelyn Tekum Amboh, Carina Törn, Ulrika Ulvenhag, Terese Wiktorsson, Åsa Wimar, Michael Killian, Claire Cowen Crouch, Jennifer Skidmore, Trevor Bender, Megan Llewellyn, Cody McCall, Arlene Meyer, Jocelyn Meyer, Denise Mulenga, Nole Powell, Jared Radtke, Shreya Roy, Preston Tucker, Dorothy Becker, Margaret Franciscus, MaryEllen Dalmagro-Elias Smith, Ashi Daftary, Mary Beth Klein, Chrystal Yates, Rajesh Adusumali, Sarah Austin-Gonzalez, Maryouri Avendano, Sandra Baethke, Brant Burkhardt, Martha Butterworth, Nicholas Cadigan, Joanna Clasen, Kevin Counts, Laura Gandolfo, Jennifer Garmeson, Veena Gowda, Christina Karges, Shu Liu, Xian Liu, Jamie Malloy, Lazarus Mramba, Cristina McCarthy, José Moreno, Hemang Parikh, Cassandra Remedios, Chris Shaffer, Susan Smith, Noah Sulman, Roy Tamura, Dena Tewey, Henri Thuma, Michael J. Toth, Ponni Vijayakandipan, Melissa Wroble, Jimin Yang, Kenneth C. Young, Liping Yu, Dongmei Miao, Kathleen M. Gillespie, Kyla Chandler, Ilana Kelland, Yassin Ben Khoud, Matthew Randell, Stephen S. Rich, Wei‐Min Chen, Suna Önengüt-Gümüşcü, Emily Farber, Rebecca Roche Pickin, Jonathan M. Davis, Jordan Davis, Dan Gallo, Jessica Bonnie, Paul Campolieto, Joseph Petrosino, Nadim J. Ajami, Matthew C. Ross, Jacqueline O’Brien, Diane S. Hutchinson, Daniel P. Smith, Xianjun Tian, Tulin Ayvaz, Auriole Tamegnon, Nguyen Truong, Hannah Moreno, Lauren Riley, Eduardo Moreno, Tonya Bauch, Lenk Kusic, Ginger Metcalf, Donna M. Muzny, HarshaVardhan Doddapaneni, Richard A. Gibbs, Chris Deigan, Thomas Briese, Todd M. Brusko, Teresa Buckner, Suzanne Bennett Johnson, Eoin McKinney, Tomi Pastinen, Steffen Ullitz Thorsen, Erick Triplett
11Citations signalées, ce qui n’est pas une note de qualité
19Institutions déclarées
4Pays d’affiliation déclarés
Rattachement africain : fi, us, se, de.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort. RESEARCH DESIGN AND METHODS: GIEs on risk of autoantibodies against either insulin (IAA) or GAD (GADA) as the first-appearing autoantibody were assessed in a 10-year follow-up of 7,867 children. Stool virome was characterized in a nested case-control study. RESULTS: GIE reports (odds ratio [OR] 2.17 [95% CI 1.39-3.39]) as well as Norwalk viruses found in stool (OR 5.69 [1.36-23.7]) at <1 year of age were associated with an increased IAA risk at 2-4 years of age. GIEs reported at age 1 to <2 years correlated with a lower risk of IAA up to 10 years of age (OR 0.48 [0.35-0.68]). GIE reports at any other age were associated with an increase in IAA risk (OR 2.04 for IAA when GIE was observed 12-23 months prior [1.41-2.96]). Impacts on GADA risk were limited to GIEs <6 months prior to autoantibody development in children <4 years of age (OR 2.16 [1.54-3.02]). CONCLUSIONS: Bidirectional associations were observed. GIEs were associated with increased IAA risk when reported before 1 year of age or 12-23 months prior to IAA. Norwalk virus was identified as one possible candidate factor. GIEs reported during the 2nd year of life were associated with a decreased IAA risk.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study
- Date Crossref
- 22/08/2023
- Éditeur
- American Diabetes Association
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Diabetes and associated disordersDiabetes Management and ResearchPancreatic function and diabetes