Sharad Purohit

Breaking the survival gap: Clinical trials as equalizers in gynecologic cancer outcomes

Rachael Piver, Rachel Watson, Alana Lanser, Akash Shah et autres

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The Ketogenic Diet and Potential Micronutrient Risks in Drug-Resistant Epilepsy Management: A Literature Review

B. B. Singh, Paige Botten, Katherine P. Richardson, Chaston Weaver et autres

The ketogenic diet (KD) is a critical, evidence-based intervention within medical nutrition therapy for managing neurological disorders. In this article, we reviewed the published research on the efficacy of the ketogenic diet and its variations in treating epilepsy, particularly for patients unresponsive …

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Peak areas of MRM transitions in PANDA and DASP sample set

Wenbo Zhi, Sharad Purohit, Shan Bai, Ashok Sharma et autres

Discovery and validation of serum protein biomarkers is of vital importance for the prediction, mechanism elucidation and monitoring response to therapy of type 1 diabetes mellitus. In this study, we attempted to replicate the results published in a 2013 issue of The …

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UTILITY OF HEMATOLOGICAL BIOMARKERS IN ASSESSING SEVERITY OF PULMONARY HYPERTENSION AND PULMONARY SARCOIDOSIS

Sharad Purohit, Varsha Taskar, N. Madala, Ahmed Mowafy et autres

Anti-αGal antibodies as an adjunct prognostic marker to CA-125/MUC16 in epithelial ovarian cancers

Rachael Piver, David Mysona, Luis Velasquez Zarate, Akash Shah et autres

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Transcriptomic Analysis of Human Lens Epithelium Tissue With and Without Cataract Surgery: Uncovering Novel Pathways of Post-Surgical Lens Epithelium Remodeling

Caili Hao, Kailin Li, Zongbo Wei, Kazi Rafsan Radeen et autres

Purpose: Cataract surgery is the most commonly performed ophthalmic procedure worldwide, yet long-term molecular adaptations of lens epithelial cells (LECs) following surgery remain poorly understood. Methods: We conducted bulk RNA sequencing on lens capsules from 34 human donors, including 17 with an …

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Financial Toxicity Survey in Patients With Gynecologic Cancer

Alana Lanser, Indira Pachipala, Rachael Piver, Bunja Rungruang et autres

OBJECTIVE: To describe the sensitivity, specificity, and positive and negative predictive values of the COST (Comprehensive Score for Financial Toxicity) survey for predicting whether patients would report altering spending habits, borrowing money, not filling prescriptions, or experiencing an inability to afford groceries …

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Abstract 6505: Evaluation of the potential role of K21 pharmacogenomics and its application in the tumor microenvironment and experimental therapeutics by using zebrafish model

Surendra K. Rajpurohit, Sai Nasanally, Pragya Rajpurohit, Devan Anmol S. Manhiani et autres

Abstract The zebrafish is an ideal vertebrate model system for glioblastoma experimental therapeutics. Our laboratory is a pioneer in glioblastoma related to zebrafish genomics. We study to identify signature genes through differential expression and pathway analysis and evaluate their potential role in …

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Elevated Inflammatory Cytokines Persist in the Aqueous Humor Years After Cataract Surgery

Caili Hao, Emily Y. Fan, Zongbo Wei, Kazi Rafsan Radeen et autres

Purpose: There is currently limited information regarding inflammation and cytokine levels in the aqueous humor (AH) of adult patients with cataract who have undergone phacoemulsification cataract extraction without other ocular comorbidities. Methods: AH samples were collected from healthy, non-surgical donors and donors …

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Comparison of Inflammatory Biomarkers in Females with and Without Patellofemoral Pain and Associations with Patella Position, Hip and Knee Kinematics, and Pain

Lori A. Bolgla, Sharad Purohit, Daniel C. Hannah, DJ Hunter

Background/Objectives: Patellofemoral pain (PFP) is believed to be a precursor to knee osteoarthritis (OA). The primary purpose of this study was to compare matrix metalloproteinase-9 (MMP-9) levels in young adult females with and without PFP. The secondary purpose was to determine the …

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Comparison of Inflammatory Biomarkers in Females with and without Patellofemoral Pain and Associations with Patella Position, Hip and Knee Kinematics, and Pain

Lori A. Bolgla, Sharad Purohit, DJ Hunter

Background/Objectives: Patellofemoral pain (PFP) is believed to be a precursor to knee osteoarthritis (OA). The primary purpose of this study was to compare matrix metalloproteinase-9 (MMP-9) levels in young, adult females with and without PFP. The secondary purpose was to determine associations …

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A Prospective, Active-controlled, Randomized, Double-blind, Multicenter, Phase III Study to Compare the Safety and Efficacy of Biosimilar Denosumab vs Reference Denosumab in the Treatment of Postmenopausal Osteoporosis

Thomas V. Paul, Bhavuk Garg, Nitin Kapoor, Vishal Patil et autres

OBJECTIVE: Denosumab, a human monoclonal antibody that exhibits strong affinity and specificity for the receptor activator of nuclear factor-kappa B ligand (RANK-L), is essential in regulating bone turnover. Its inhibition of RANK-L decreases bone resorption by preventing the development, function, and survival …

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