Multiplex analysis of inflammatory proteins associated with risk of coronary artery disease in type‐1 diabetes patients
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Le résumé fourni par la source
Abstract Background Chronic uncontrolled hyperglycemia, a precursor to chronic low‐grade inflammation, is a leading cause of coronary artery disease (CAD) due to plaque buildup in type‐1 diabetes (T1D) patients. We evaluated levels of 22 inflammatory markers in cross‐sectional serum samples from 1222 subjects to evaluate their potential as risk factors for CAD in T1D patients. Hypothesis Circulating levels of markers of inflammation may be the risk factors for incident CAD. Methods The T1D subjects were divided into two groups: those without CAD (n = 1107) and with CAD (n = 115). Serum levels of proteins were assayed using multiplex immunoassays on a Luminex Platform. Differences between the two groups were made by univariate analysis. Multivariate logistic regression was used to ascertain the potential of proteins as risk factors for CAD. Influence of age, duration of diabetes, sex, hypertension, and dyslipidemia was determined in a stepwise manner. Serum levels of 22 proteins were combined into a composite score using Ridge regression for risk‐based stratification. Results Mean levels of CRP, IGFBP1, IGFBP2, insulin‐like growth factors binding protein‐6 (IGFBP6), MMP1, SAA, sTNFRI, and sTNFRII were elevated in CAD patients (n = 115) compared to T1D patients without CAD (nCAD, n = 1107). After adjusting for age, duration of diabetes, sex, hypertension, and dyslipidemia, higher levels of sTNFRI (odds ratio [OR] = 2.18, 1.1 × 10−3), sTNFRII (OR = 1.52, 1 × 10−2), and IGFBP6 (OR = 3.62, 1.8 × 10−3) were significantly associated with CAD. The composite score based on Ridge regression, was able to stratify CAD patients into low, medium, and high‐risk groups. Conclusions The results show activation of the TNF pathway in CAD patients. Evaluating these markers in serum can be a potential tool for identifying high‐risk T1D patients for intensive anti‐inflammatory therapeutic interventions.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multiplex analysis of inflammatory proteins associated with risk of coronary artery disease in type‐1 diabetes patients
- Date Crossref
- 11/10/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Augusta University pays non établi dans la noticeUniversité ou école supérieure
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Yale University pays non établi dans la noticeUniversité ou école supérieure
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National Institutes of Health pays non établi dans la noticeOrganisme public
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School of Medicine Medical College of Georgia Augusta Georgia USA pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Center for Biotechnology and Genomic Medicine pays non établi dans la noticeUniversité ou école supérieure
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Department of Internal Medicine Yale School of Medicine New Haven Connecticut USA pays non établi dans la noticeUniversité ou école supérieure
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Department of Obstetrics and Gynecology Medical College of Georgia pays non établi dans la noticeUniversité ou école supérieure
Augusta University, Yale University et National Institutes of Health, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.