Accès ouvert déclaré
2024
article
Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study
Leena Hakola, Lazarus K. Mramba, Ulla Uusitalo, Carin Andrén Aronsson, Sandra Hummel, Sari Niinistö, Iris Erlund, Jimin Yang, Marian Rewers, Beena Akolkar, Richard McIndoe, Stephen S. Rich, William Hagopian, Anette G. Ziegler, Åke Lernmark, Jorma Toppari, Jeffrey P. Krischer, Jill M. Norris, Suvi Μ. Virtanen, Kimberly Bautista, Judith Baxter, Daniel Felipe-Morales, Brigitte I. Frohnert, Marisa Stahl, Isabel Flores Garcia, Patricia Gesualdo, Sierra Hays, Michelle Hoffman, R. Johnson, Rachel Karban, Edwin Liu, Leila Loaiza, Holly O’Donnell, Loana Thorndahl, Andrea K. Steck, Kathleen Waugh, Olli Simell, Annika Adamsson, Suvi Ahonen, Sirpa Anttila, Anne Hekkala, Tiia Honkanen, T Hurskainen, Heikki Hyöty, Jorma Ilonen, Saori Itoshima, Minna Jokipolvi, Sanna Jokipuu, Taru Karjalainen, Leena Eklund Karlsson, Jukka Kero, Marika Korpela, Jaakko J. Koskenniemi, Miia Kähönen, Mikael Knip, Minna-Liisa Koivikko, Katja Kokkonen, Merja Koskinen, Mirva Koreasalo, Kalle Kurppa, Salla Kuusela, Jarita Kytölä, Mia Laakso, Jutta E. Laiho, Tiina Latva-aho, Siiri Leisku, Laura Leppänen, Katri Lindfors, Maria Lönnrot, Elina Mäntymäki, Markus Mattila, Maija E. Miettinen, Tiina Niininen, Noora Nurminen, Sami Oikarinen, Hanna-Leena Oinas, Paula Ollikainen, Zhian Othmani, Sirpa Pohjola, Solja Raja-Hanhela, Jenna Rautanen, Anne Riikonen, Minna Romo, Juulia Rönkä, Nelli Rönkä, Satu Simell, Aino Tihinen, Päivi Tossavainen, Mari Vähä-Mäkilä, Eeva Varjonen, Riitta Veijola, Irene Viinikangas, Silja Vilmi, Desmond Schatz, Diane Hopkins, Michael J. Haller, Melissa Gardiner, Ashok Sharma, Laura M. Jacobsen, Percy Gordon, Jennifer Hosford, Sharon Maina, Chelsea Salmon, Ezio Bonifacio, Cigdem Gezginci, Willi Grätz, Anja Heublein, Annette Knopff, Sibylle Koletzko, Claudia Ramminger, Roswith Roth, Jennifer Schmidt, Marlon Scholz, Joanna Stock, Katharina Warncke, Lorena Wendel, Christiane Winkler, Daniel Agardh, Rasmus Bennet, Corrado Cilio, Susanne Dahlberg, Malin Goldman Tsubarah, Emelie Ericson-Hallström, Lina Fransson, Emina Halilovic, Susanne Hyberg, Berglind Jónsdóttir, Naghmeh Karimi, Helena Elding Larsson, Marielle Lindström, Markus Lundgren, Marlena Maziarz, Jessica Melin, Kobra Rahmati, Anita Ramelius, Falastin Salami, Anette Sjöberg, Evelyn Tekum Amboh, Carina Törn, Michael Killian, Claire Cowen Crouch, Jennifer Skidmore, Trevor Bender, Megan Llewellyn, Cody McCall, Arlene Meyer, Jocelyn Meyer, Denise Mulenga, Nole Powell, Jared Radtke, Shreya Roy, Dorothy Becker, Margaret Franciscus, MaryEllen Dalmagro-Elias Smith, Ashi Daftary, Mary Beth Klein, Chrystal Yates, Rajesh Adusumali, Sarah Austin-Gonzalez, Maryouri Avendano, Sandra Baethke, Brant Burkhardt, Martha Butterworth, Nicholas Cadigan, Joanna Clasen, Kevin Counts, Laura Gandolfo, Jennifer Garmeson, Veena Gowda, Christina Karges, Shu Liu, Xiang Liu, Kristian Lynch, Jamie Malloy, Lazarus Mramba, Cristina McCarthy, José Moreno, Hemang Parikh, Cassandra Remedios, Chris Shaffer, Noah Sulman, Roy Tamura, Dena Tewey, Henri Thuma, Michael J. Toth, Kendra Vehik, Ponni Vijayakandipan, Melissa Wroble, Kenneth C. Young, Liping Yu, Dongmei Miao, Kathleen M. Gillespie, Kyla Chandler, Olivia Pearce, Sarah Stollery, Elinor Balch, Hanah Batholomew, Zahra Hashmi, Thomas Briese, Todd M. Brusko, Teresa Buckner, Suzanne Bennett Johnson, Eoin McKinney, Tomi Pastinen, Steffen Ullitz Thorsen, Eric W. Triplett
9Citations signalées, ce qui n’est pas une note de qualité
19Institutions déclarées
4Pays d’affiliation déclarés
Rattachement africain : fi, us, se, de.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
PURPOSE: The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years. METHODS: We followed 8500 T1D-susceptible children born in the U.S., Finland, Sweden, and Germany in 2004 -2010 from the Environmental Determinants of Diabetes in the Young (TEDDY) study, which is a prospective observational birth cohort. Dietary intake of seven B vitamins was calculated from foods and dietary supplements based on 24-h recall at 3 months and 3-day food records collected regularly from 6 months to 10 years of age. Cox proportional hazard models were adjusted for energy, HLA-genotype, first-degree relative with T1D, sex, and country. RESULTS: A total of 778 (9.2) children developed at least one autoantibody (any IA), and 335 (3.9%) developed multiple autoantibodies. 280 (3.3%) children had IAA and 319 (3.8%) GADA as the first autoantibody. 344 (44%) children with IA progressed to T1D. We observed that higher intake of niacin was associated with a decreased risk of developing multiple autoantibodies (HR 0.95; 95% CI 0.92, 0.98) per 1 mg/1000 kcal in niacin intake. Higher intake of pyridoxine (HR 0.66; 95% CI 0.46, 0.96) and vitamin B12 (HR 0.87; 95% CI 0.77, 0.97) was associated with a decreased risk of IAA-first autoimmunity. Higher intake of riboflavin (HR 1.38; 95% CI 1.05, 1.80) was associated with an increased risk of GADA-first autoimmunity. There were no associations between any of the B vitamins and the outcomes "any IA" and progression from IA to T1D. CONCLUSION: In this multinational, prospective birth cohort of children with genetic susceptibility to T1D, we observed some direct and inverse associations between different B vitamins and risk of IA.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study
- Date Crossref
- 27/02/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Diabetes and associated disordersCeliac Disease Research and ManagementNutritional Studies and Diet