Accès ouvert déclaré
2025
article
The Contribution of BMI to a Young Child’s Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2
Jaakko J. Koskenniemi, Joanna Clasen, Lu You, Hemang Parikh, Kendra Vehik, Jimin Yang, Ulla Uusitalo, Riitta Veijola, Michael J. Haller, Anette G. Ziegler, Marian Rewers, William Hagopian, Beena Akolkar, Åke Lernmark, Jorma Toppari, Helena Elding Larsson, Jeffrey P. Krischer, Kristian Lynch, Marian Rewers, Kimberly Bautista, Judith Baxter, Daniel Felipe-Morales, Brigitte I. Frohnert, Marisa Stahl, Patricia Gesualdo, Michelle Hoffman, Randi K. Johnson, Rachel Karban, Edwin Liu, Jill Norris, Holly O’Donnell, Andrea K. Steck, Kathleen Waugh, Olli Simell, Annika Adamsson, Suvi Ahonen, Iris Erlund, Sirpa Anttila, Leena Hakola, Sanni Heikura, Tiia Honkanen, Heikki Hyöty, Jorma Ilonen, Saori Itoshima, Sanna Jokipuu, Taru Karjalainen, Leena Eklund Karlsson, Pieta Kemppainen, Jukka Kero, Marika Korpela, Miia Kähönen, Mikael Knip, Minna-Liisa Koivikko, Katja Kokkonen, Merja Koskinen, Mirva Koreasalo, Kalle Kurppa, Salla Kuusela, Jutta E. Laiho, Tiina Latva-aho, Siiri Leisku, Laura Leppänen, Katri Lindfors, Maria Lönnrot, Elina Mäntymäki, Markus Mattila, Maija E. Miettinen, Teija Mykkänen, Tiina Niininen, Sari Niinistö, Noora Nurminen, Sami Oikarinen, Hanna-Leena Oinas, Paula Ollikainen, Zhian Othmani, Sirpa Pohjola, Jenna Rautanen, M. F. Rein, Minna Romo, Juulia Rönkä, Nelli Rönkä, Noora Ruotsalainen, Satu Simell, Päivi Tossavainen, Mari Vähä-Mäkilä, Eeva Varjonen, Irene Viinikangas, Suvi Μ. Virtanen, Richard McIndoe, Desmond Schatz, Diane Hopkins, Melissa Gardiner, Ashok Sharma, Laura M. Jacobsen, Percy Gordon, Jennifer Hosford, Ezio Bonifacio, Cigdem Sanverdi, Anja Heublein, Sandra Hummel, Annette Knopff, Melanie Köger, Sibylle Koletzko, Claudia Ramminger, Roswith Roth, Jennifer Schmidt, Marlon Scholz, Joanna Stock, Katharina Warncke, Christiane Winkler, Daniel Agardh, Carin Andrén Aronsson, Rasmus Bennet, Corrado Cilio, Susanne Dahlberg, Malin Goldman Tsubarah, Emelie Ericson-Hallström, Lina Fransson, Emina Halilovic, Susanne Hyberg, Berglind Jónsdóttir, Naghmeh Karimi, Markus Lundgren, Jessica Melin, Kobra Rahmati, Anita Ramelius, Falastin Salami, Anette Sjöberg, Evelyn Tekum Amboh, Carina Törn, Terese Wiktorsson, Eva Andersson, Rawya Antar, Maria Ask, Jenny Bremer, Ulla-Marie Carlsson, Magdalena Delikat Kulinski, Annika Fors, Ulla Fält, Thomas Gard, Joanna Gerardsson, Monika Hansen, Anna Hansson, Carina Hansson, Gertie Hansson, Elin M Hård Af Segerstad, Hanna Jisser, Fredrik Johansen, Linda Jönsson, Silvija Jović, Sigrid Lenrick Forss, Barbro Lernmark, Marielle Lindström, Maria Markan, Theodosia Massadakis, Marlena Maziarz, Zeliha Mestan, Maria Månsson Martinez, Caroline Nilsson, Emma Nilsson, Yohanna Nordh, Karin Ottosson, Sara Rang, Anna Rosenquist, Monika Sedig Järvirova, Sara Sibthorpe, Birgitta Janerot-Sjöberg, Ulrika Swartling, Erika Trulsson, Ulrika Ulvenhag, Anne Wallin, Ingrid Wigheden, Åsa Wimar, Sofie Åberg, Michael Killian, Jennifer Skidmore, Ben Kim, Cody McCall, Arlene Meyer, Jared Radtke, Shreya Roy, Dorothy Becker, Margaret Franciscus, MaryEllen Dalmagro-Elias Smith, Ashi Daftary, Mary Beth Klein, Chrystal Yates, Rajesh Adusumali, Sarah Austin-Gonzalez, Maryouri Avendano, Sandra Baethke, Brant Burkhardt, Martha Butterworth, Nicholas Cadigan, Kevin Counts, Laura Gandolfo, Jennifer Garmeson, Veena Gowda, Shu Liu, Xiang Liu, Kristian Lynch, Jamie Malloy, Lazarus Mramba, Cristina McCarthy, Cassandra Remedios, Chris Shaffer, Susan Smith, Noah Sulman, Roy Tamura, Dena Tewey, Henri Thuma, Michael J. Toth, Ponni Vijayakandipan, Melissa Wroble, Jimin Yang, Kenneth C. Young, Michael Abbondondolo, Lori Ballard, Rasheedah Brown, David Cuthbertson, Stephen Dankyi, Christopher Eberhard, Steven Fiske, David Hadley, Kathleen Heyman, Belinda Hsiao, Christina Karges, Francisco Perez Laras, Hye Seung Lee, Qian Li, Colleen Maguire, Wendy McLeod, Aubrie Merrell, Steven Meulemans, José Moreno, Ryan Quigley, Laura Smith, Liping Yu, Dongmei Miao, Kathleen M. Gillespie, Kyla Chandler, Olivia Pearce, Sarah Stollery, Elinor Balch, Hanah Batholomew, Zahra Hashmi, Chris Deigan, Thomas Briese, Todd M. Brusko, Teresa Buckner, Suzanne Bennett Johnson, Eoin McKinney, Tomi Pastinen, Steffen Ullitz Thorsen, Eric W. Triplett
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Le résumé fourni par la source
OBJECTIVE: Childhood obesity may impact the risk of islet autoimmunity (IA). The trajectory of BMI through childhood resembles the early peak incidence of first-appearing autoantibodies against insulin (IAA-first) but not GAD65 (GADA-first). We studied whether a child's BMI can impact the age-related risk of first-appearing IA phenotypes. RESEARCH DESIGN AND METHODS: We identified 7,724 children at risk for IA with at least three BMI measurements in The Environmental Determinants of Diabetes in the Young (TEDDY) study. We modeled the risk of IAA-first, GADA-first, and IA overall on a child's BMI z score and change in BMI during infancy (age 2 weeks to 1.5 years, n = 7,724), early childhood (age 1.5-8.5 years, n = 6,396), and puberty (age 8.5-15 years, n = 4,732) using joint modeling of longitudinal BMI and time-to-event IA. RESULTS: An infant's BMI z score was not associated with IA risk before 18 months of age (n = 185, hazard ratio [HR] 1.03 [95% CI 0.88, 1.19]). In contrast, a child's BMI correlated with an increased risk of IA from 1.5 to 8.5 years of age (n = 470, HR 1.20 [95% CI 1.04, 1.32]) and from 8.5 to 15 years of age (n = 209, HR 1.27 [95% CI 1.09, 1.49]). No interactions with first-appearing IA phenotypes were observed. However, high BMI z score (SD >0.5) from age 9 months increased the risk of IA in early childhood, specifically for children with HLA-DR4/4 or HLA-DR4/8 and not with HLA-DR3/3 or HLA-DR3/4 (HLA ∗ BMI interaction, P < 0.005). CONCLUSIONS: The contribution of BMI to risk of IA during early childhood is dependent on the HLA-DR-DQ genotype more so than the first-appearing IA phenotype.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Contribution of BMI to a Young Child’s Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2
- Date Crossref
- 09/10/2025
- Éditeur
- American Diabetes Association
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Diabetes and associated disordersPancreatic function and diabetesGenetic Associations and Epidemiology