Bianka M. Zanini

Impact of miR-181a-5p and miR-1249-3p treatment on the visceral adipose tissue transcriptome of female mice

Driele Neske Garcia, Bianka M. Zanini, Sarah Ashiqueali, Miguel A Brieño-Enriquez et autres

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Reduced fertility induced by MASLD in female mice is improved by senolytic treatment

Jéssica D. Hense, José V. V. Isola, Driele Neske Garcia, Bianka M. Zanini et autres

Senescent cells have been implicated in the pathogenesis of metabolic dysfunction-associated liver disease (MASLD), which can negatively affect female fertility. Senolytic drugs are reported to eliminate senescent cells in various tissues, including the ovary. However, the efficacy of senolytic drugs in reducing …

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High-fat and choline-deficient western diets disrupt the ovarian microenvironment in mice

César A Pinzón-Osorio, Camila L Moreira, Ines L Assis, Larissa S Magalhães et autres

Obesity and metabolic dysfunction induced by high-fat and Western-style diets are key contributors to reproductive aging. However, the specific contributions of diet-induced obesity and liver damage to ovarian aging and follicle depletion remain unclear. This study investigated the impact of a high-fat …

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Timing and duration of calorie restriction determine its impact on ovarian aging in female mice

Juliane B. Prosczek, Jéssica D. Hense, Driele Neske Garcia, Shara P. Sodré et autres

This study investigated how the timing and duration of 30% caloric restriction (CR) affect ovarian aging in mice. Mice were assigned to one of four groups: ad libitum (AL) control, long-term CR (3-11 months; CR/CR), early short-term CR (3-7 months; CR/AL), and …

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The influence of ovarian activity and menopause on mental health: Evidence from animal models and women

Ediana V Neitzke, Bianka M. Zanini, Marcelo Borges Cavalcante, Jeffrey B. Mason et autres

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Extracellular vesicles from cyclic mice modulate liver transcriptome in estroupause mice independent of age

Bianka M. Zanini, Bianca M. Ávila, Jéssica D. Hense, Driele Neske Garcia et autres

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EXOSOMES FROM CYCLIC MICE MODULATE LIVER TRANSCRIPTOME IN ESTROUPAUSE MICE INDEPENDENT OF AGE

Bianka M. Zanini, Bianca M. Ávila, Jéssica D. Hense, Driele Neske Garcia et autres

Abstract Background Exosomes are extracellular vesicles secreted by cells that contain microRNAs (miRNAs). These miRNAs can induce changes in gene expression and function of recipient cells. In different cells exosome content can change with age and physiological state affecting tissues function and …

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Effect of senolytic drugs in young female mice chemically induced to estropause

Bianca M. Ávila, Bianka M. Zanini, Karina Pereira Luduvico, Thaís Larré Oliveira et autres

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MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice

Jéssica D. Hense, Driele Neske Garcia, Bianka M. Zanini, Mariana M. Barreto et autres

Senescent cells have been linked to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the effectiveness of senolytic drugs in reducing liver damage in mice with MASLD is not clear. Additionally, MASLD has been reported to adversely affect male reproductive …

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Early life interventions metformin and trodusquemine metabolically reprogram the developing mouse liver through transcriptomic alterations

Sarah Ashiqueali, Augusto Schneider, Xiang Zhu, Ewelina Juszczyk et autres

Recent studies have demonstrated the remarkable potential of early life intervention strategies at influencing the course of postnatal development, thereby offering exciting possibilities for enhancing longevity and improving overall health. Metformin (MF), an FDA-approved medication for type II diabetes mellitus, has recently …

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Effect of senolytic drugs in young female mice chemically induced to estropause

Bianca M. Ávila, Bianka M. Zanini, Karina Pereira Luduvico, Thaís Larré Oliveira et autres

Abstract Aims This study aimed to assess metabolic responses and senescent cell burden in young female mice induced to estropause and treated with senolytic drugs. Main methods Estropause was induced by 4-vinylcyclohexene diepoxide (VCD) injection in two-month-old mice. The senolytics dasatinib and …

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Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice

Bianka M. Zanini, Bianca M. Ávila, Driele Neske Garcia, Jéssica D. Hense et autres

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