EXOSOMES FROM CYCLIC MICE MODULATE LIVER TRANSCRIPTOME IN ESTROUPAUSE MICE INDEPENDENT OF AGE
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Le résumé fourni par la source
Abstract Background Exosomes are extracellular vesicles secreted by cells that contain microRNAs (miRNAs). These miRNAs can induce changes in gene expression and function of recipient cells. In different cells exosome content can change with age and physiological state affecting tissues function and health. Aims Therefore, the aim of this study was to characterize the miRNA content and role of exosomes from cyclic female mice in the modulation of liver transcriptome in estropausal mice. Main Methods Two-month-old female mice were induced to estropause using 4-vinylcyclohexene diepoxide (VCD). At six months of age VCD-treated mice were divided in control group (VCD) and exosome treated group (VCD+EXO), which received 10 injections at 3-day intervals of exosomes extracted from serum of cyclic female mice (CTL). Key findings Exosome injection in estropausal mice had no effect on body mass, insulin sensitivity or organ weight. We observed ten miRNAs differentially regulated in serum exosomes of VCD compared to CTL mice. In the liver we observed 931 genes differentially expressed in VCD+EXO compared to VCD mice. Interestingly, eight pathways were up-regulated in liver by VCD treatment and down-regulated by exosome treatment, indicating that exosomes from cyclic mice can reverse changes promoted by estropause in liver. Cyp4a12a expression which is male-specific was increased in VCD females and not reversed by exosome treatment. Significance Our findings indicate that miRNAs content in exosomes is regulated by estropause in mice independent of age. Additionally, treatment of estropausal mice with exosomes from cyclic mice can partially reverse changes in liver transcriptome.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- EXOSOMES FROM CYCLIC MICE MODULATE LIVER TRANSCRIPTOME IN ESTROUPAUSE MICE INDEPENDENT OF AGE
- Date Crossref
- 06/11/2024
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade Federal de Pelotas Faculdade de Nutrição pays non établi dans la noticeUniversité ou école supérieure
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University of Central Florida pays non établi dans la noticeUniversité ou école supérieure
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University of Pittsburgh Department of Obstetrics pays non établi dans la noticeUniversité ou école supérieure
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Magee-Womens Research Institute pays non établi dans la noticeStructure de recherche
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Utah State University pays non établi dans la noticeUniversité ou école supérieure
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Poznan University of Medical Sciences Department of Head and Neck Surgery pays non établi dans la noticeUniversité ou école supérieure
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College of Medicine pays non établi dans la noticeUniversité ou école supérieure
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College of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
Faculdade de Nutrição — Universidade Federal de Pelotas, University of Central Florida et Department of Obstetrics — University of Pittsburgh, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.