High-fat and choline-deficient western diets disrupt the ovarian microenvironment in mice
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Le résumé fourni par la source
Obesity and metabolic dysfunction induced by high-fat and Western-style diets are key contributors to reproductive aging. However, the specific contributions of diet-induced obesity and liver damage to ovarian aging and follicle depletion remain unclear. This study investigated the impact of a high-fat diet (HFD) and a choline-deficient Western diet (CDWD) on ovarian aging in two mouse strains. Three-month-old female mice (C57BL/6 and Swiss) were assigned to a control standard diet (CSD), choline-deficient control diet (CDC), HFD, or CDWD for 10 weeks. C57BL/6 mice fed an HFD exhibited significant body mass gain, intra-abdominal fat accumulation, and insulin resistance, whereas Swiss mice did not develop obesity. Both strains developed hepatomegaly and steatohepatitis under CDWD in the absence of obesity, as expected for this choline-deficient diet. HFD and CDWD increased serum cholesterol and high-density lipoprotein levels in both strains. The ovarian follicle reserve was unaffected by diet or strain, despite a modest increase in follicular atresia in HFD-fed C57BL/6 mice. However, both HFD and CDWD promoted macrophage infiltration, lipofuscin accumulation, stromal fibrosis, and increased stromal proliferative activity. These findings demonstrate that metabolic stress from HFD and CDWD remodels the ovarian microenvironment and induces early hallmarks of ovarian aging independent of follicle depletion. Metabolic responses were strain-dependent; however, both obesity-driven metabolic dysfunction and obesity-independent liver injury led to similar ovarian microenvironment remodeling. This highlights a previously underappreciated pathway linking metabolic diseases to reproductive decline and suggests that ovarian microenvironmental remodeling is an early sign of ovarian aging in response to diet-induced metabolic stress.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- High-fat and choline-deficient western diets disrupt the ovarian microenvironment in mice
- Date Crossref
- 30/01/2026
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade Federal de Pelotas Cancer Biotechnology Laboratory pays non établi dans la noticeUniversité ou école supérieure
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Institute of Biochemistry and Physiology of Plants and Microorganisms pays non établi dans la noticeStructure de recherche
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Oklahoma Medical Research Foundation Aging & Metabolism Research Program pays non établi dans la noticeOrganisation à but non lucratif
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Oklahoma City VA Medical Center pays non établi dans la noticeÉtablissement de santé
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Magee-Womens Research Institute pays non établi dans la noticeStructure de recherche
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College of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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College of Nutrition pays non établi dans la noticeUniversité ou école supérieure
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Center for Chemical pays non établi dans la noticeInstitution
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Laboratory of Biochemistry and Molecular Biology of Microorganisms pays non établi dans la noticeStructure de recherche
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Oklahoma City Veterans Affairs Medical Center pays non établi dans la noticeÉtablissement de santé
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University of Pittsburgh Magee-Womens Research Institute pays non établi dans la noticeUniversité ou école supérieure
Cancer Biotechnology Laboratory — Universidade Federal de Pelotas, Institute of Biochemistry and Physiology of Plants and Microorganisms et Aging & Metabolism Research Program — Oklahoma Medical Research Foundation, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.