Xiaohan Shi

Network analysis of the relationships between psychological capital and emotional exhaustion in clinical nurses during the post-epidemic period

Chao Wu, Ning Zha, Kai Zhang, Mei Wang et autres

cn (code pays fourni par la source)

Correction: Latent profile analysis of moral resilience among clinical nurses and its association with ethical behavior: a multi-hospital cross-sectional study in China

Xiaohan Shi, Ying Zhang, Hongjuan Lang, Rui Wang et autres

[This corrects the article DOI: 10.3389/fpubh.2026.1787493.].

cn (code pays fourni par la source)

Latent profile analysis of moral resilience among clinical nurses and its association with ethical behavior: a multi-hospital cross-sectional study in China

Xiaohan Shi, Yu Zhang, Hongjuan Lang, Rui Wang et autres

Objective To explore the categories of the moral resilience latent profile of clinical nurses, analyze the influencing factors of different categories, and explore the correlation between them and ethical behavior. Methods By convenience sampling, nurses from 16 level-two-and-above hospitals in China were …

cn (code pays fourni par la source)

Senescence-driven molecular subtyping in pancreatic cancer: a multi-omics framework for precision medicine

Meilong Shi, Penghao Li, Bo Li, Huan Wang et autres

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with a five-year survival rate below 15%, largely due to tumor heterogeneity and limited therapeutic options. While senescence-related genes (SRGs) are implicated in cancer progression, their pancreas-specific roles in PDAC subtyping and treatment …

cn (code pays fourni par la source)

An Ant-Nest-Structured Wearable Sensor with pH Calibration for Reliable Monitoring of Sweat Glucose

Qingwen Zhang, Danfeng Jiang, Zhe Sun, Xiaohan Shi et autres

Sweat glucose detected by wearable sensors can serve as a potential reference factor for diabetes management. However, inefficient sweat collection and fluctuating sweat pH hinder the precise detection of glucose. Herein, we designed a wearable sensing system comprising an ant-nest-structured sensor and …

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A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy

Yunguang Li, Shijie Tang, Huan Wang, Hongwen Zhu et autres

Chemotherapy remains the primary treatment for pancreatic ductal adenocarcinoma (PDAC), but most patients ultimately develop resistance. Here, we established 260 pancreatic cancer organoid lines, followed by extensive multi-omics profiling and therapeutic sensitivity assessments. Integrated analyses uncovered 6 novel coding and 35 noncoding …

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ODFormer: a Virtual Organoid for Predicting Personalized Therapeutic Responses in Pancreatic Cancer

Jing Xu, Xiaolu Yang, Yunguang Li, Huang Wang et autres

Abstract Pancreatic cancer (PC) patient-derived organoids (PDOs) faithfully recapitulate therapeutic responses but face clinical translation barriers, including high costs and technical complexity. To address these problems and the lack of frameworks for PDO-based drug-response assays, we developed ODFormer, a computational framework that …

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Targeting protein glycosylation and cholesterol metabolism in chemoresistant pancreatic cancer

Yunguang Li, Shijie Tang, Huan Wang, Hongwen Zhu et autres

Abstract Chemotherapy remains the cornerstone of pancreatic ductal adenocarcinoma (PDAC) treatment. However, most cases of PDAC finally progress to advanced chemoresistant disease. This highlights an urgent need to develop new pharmacological strategies to overcome chemotherapy resistance using clinical grade inhibitors. Here, we …

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Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups

Shunrong Ji, Lihua Cao, Jing Gao, Yang Du et autres

The majority of neuroendocrine neoplasms in pancreas are non-functional pancreatic neuroendocrine tumors (NF-PanNETs), which exhibit a high occurrence of distant metastases with limited therapeutic options. Here, we perform a comprehensive molecular characterization of 108 NF-PanNETs through integrative analysis of genomic, transcriptomic, proteomic, …

cn, us, gb (code pays fourni par la source)

Efficacy and safety of PCA-assisted continuous paravertebral block in subacute herpes zoster-associated pain: study protocol for a randomized, controlled, double-blind superiority trial

Bo Yang, Xiaohan Shi, Yanan Xu, Qing Wang et autres

BACKGROUND: Pain management for herpes zoster-associated pain (ZAP) is essential to improve patients' daily lives and potentially intervene in the chronicity. Long-lasting, repetitive painful stimuli might lead to central sensitization and neuropathic pain generation. The subacute phase is the main period for …

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Pathogenic germline variants in Chinese pancreatic adenocarcinoma patients

Xiaoyi Yin, Hui Shen, Huan Wang, Qingchen Wang et autres

Putting pancreatic adenocarcinoma (PAAD) screening into perspective for high-risk individuals could significantly reduce cancer morbidity and mortality. Previous studies have profiled somatic mutations in PAAD. In contrast, the prevalence of mutations in PAAD predisposition genes has not been defined, especially in the …

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124TiP: TROPION-Lung15: A phase III study of datopotamab deruxtecan (Dato-DXd) ± osimertinib vs platinum doublet chemotherapy in patients with EGFR-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC) and disease progression on prior osimertinib

E. Nadal, P.K. Cheema, Yi-Long Lung Cancer Wu, M-J. Ahn et autres

es, ca, cn, kr, jp, gb, nl, fr, pl, sg, ch, us (code pays fourni par la source)