Huang Wang

Investigating systemic immune and microbiome associates of response to immune checkpoint inhibition in patients with solid tumours

Huang Wang

ODFormer: a Virtual Organoid for Predicting Personalized Therapeutic Responses in Pancreatic Cancer

Jing Xu, Xiaolu Yang, Yunguang Li, Huang Wang et autres

Abstract Pancreatic cancer (PC) patient-derived organoids (PDOs) faithfully recapitulate therapeutic responses but face clinical translation barriers, including high costs and technical complexity. To address these problems and the lack of frameworks for PDO-based drug-response assays, we developed ODFormer, a computational framework that …

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Post-translational modifications of immune checkpoints: unlocking new potentials in cancer immunotherapy

Qiongjie Hu, Yueli Shi, Huang Wang, Bing Keong Li et autres

Immunotherapy targeting immune checkpoints has gained traction across various cancer types in clinical settings due to its notable advantages. Despite this, the overall response rates among patients remain modest, alongside issues of drug resistance and adverse effects. Hence, there is a pressing …

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Determination and Risk Assessment of Phenolic Endocrine-Disrupting Chemicals in the Rivers of Wuhan

Yulin Zhang, Huang Wang, Qiwei Zhang, Xu Zhang et autres

Pollution from phenolic endocrine-disrupting chemicals (PEDCs) poses a significant challenge to aquatic ecosystems. However, information on their occurrence and risks in Wuhan’s two primary rivers is limited. This study analyzed nine PEDCs and water quality parameters, detecting four: 4-n-nonylphenol (22–109 ng/L), octylphenol …

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Analysis of Sulfate Transporter Gene Family 3 in Rice

Ruili Li, Xu Zhuang, Wanxia Wang, Huang Wang et autres

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A chromosome-scale genome assembly and epigenomic profiling reveal temperature-dependent histone methylation in iridoid biosynthesis regulation in Scrophularia ningpoensis

Qing Xu, Chang Liu, Bin Li, Kewei Tian et autres

Abstract Understanding how medicinal plants adapt to global warming, particularly through epigenetic mechanisms that modify phenotypes without changing DNA sequences is crucial. Scrophularia ningpoensis Hemsl., a traditional Chinese Medicine (TCM), produces bioactive compounds that are influenced by environmental temperatures, making it an …

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Ordered lithiophilic Crown Ether Sites in a 2D Coordination Network for Dendrite-Free Lithium Deposition

Runhao Zhang, Zhonghang Chen, Jialong Jiang, Xuelong Liao et autres

A watch-and-wait approach for metachronous multiple colon cancer following neoadjuvant immunotherapy: a case report

Huang Wang, Shouru Zhang

The application of immunotherapy for treating colorectal cancer (CRC) is currently a research hotspot, and neoadjuvant immunotherapy has shown initial success in treating CRC. The watch-and-wait (W&W) approach is often used after achieving a clinical complete response (cCR) following preoperative treatment of …

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GLUT3 transcriptional activation by ZEB1 fuels the Warburg effect and promotes ovarian cancer progression

Furong Lin, Lin Ma, Shengnan Yu, Jing Lin et autres

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Multielement Fingerprints Combined with Chemometrics for Geographical Discrimination of Chuju, a Cultivar of Chrysanthemum Morifolium Ramat

Shijun Yu, Longzhu Dou, Ruizhu Xu, Ruibo Xu et autres

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Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation

Huang Wang, Haibo Du, Rui Ren, Tingting Du et autres

Stereocilia are actin-based cell protrusions of inner ear hair cells and are indispensable for mechanotransduction. Ankle links connect the ankle region of developing stereocilia, playing an essential role in stereocilia development. WHRN, PDZD7, ADGRV1 and USH2A have been identified to form the …

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Deafness-related protein PDZD7 forms complex with the C-terminal tail of FCHSD2

Huang Wang, Dange Zhao, Haibo Du, Xiaoyan Zhai et autres

In cochlea, deafness-related protein PDZD7 is an indispensable component of the ankle link complex, which is critical for the maturation of inner-ear hair cell for sound perception. Ankle links, connecting the different rows of cochlear stereocilia, are essential for the staircase-like development …

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