Zixuan Fang

Cancer-derived IGKC Suppresses Interferon Signaling and Promotes Tumor Metastasis

C Sun, Xucui Zhuang, Zixuan Fang, Liu Y et autres

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Heterogeneous cellular responses to hyperthermia support combined intraperitoneal hyperthermic immunotherapy for ovarian cancer mouse models

Xingyuan Hu, X. S. Kang, Faming Zhao, Yaoyuan Cui et autres

The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development of rational combination therapies based on hyperthermia (HT). This study reports the preliminary results of the neoadjuvant HIPEC (NHIPEC) trial (ChiCTR2000038173), demonstrating enhanced tumor response in high-grade …

cn (code pays fourni par la source)

Single-cell transcriptomic analysis reveals characteristic feature of macrophage reprogramming in liver Mallory-Denk bodies pathogenesis

Zixuan Fang, Bei Zhong, Yi Shi, Wanmei Zhou et autres

Chronic liver diseases are highly linked with mitochondrial dysfunction and macrophage infiltration. Mallory-Denk bodies (MDBs) are protein aggregates associated with hepatic inflammation, and MDBs pathogenesis could be induced in mice by feeding 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC). Here, we investigate the macrophage heterogeneity and the …

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Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment

Ke Tan, Zixuan Fang, Lingzhen Kong, Cheng Chen et autres

G2 and S phase-expressed-1 (GTSE1) has been reported to be associated with poor prognosis in many cancer types. However, the knowledge of GTSE1 across 33 cancer types remains scarce, and the mechanisms by which GTSE1 promotes cancer development remain incompletely understood. R …

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Single-cell transcriptomes identifies characteristic features of mouse macrophages in liver Mallory-Denk bodies formation

Rong Zhang, Bei Zhong, Jiashan He, Xinyu Yang et autres

Mallory-Denk bodies (MDBs) consist of intracellular aggregates of misfolded proteins in ballooned hepatocytes and serve as important markers of progression in certain liver diseases. Resident hepatic macrophage-mediated inflammation influences the development of chronic liver diseases and cancer. Here, the first systematic study …

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A Novel Therapeutic Tumor Vaccine Targeting MUC1 in Combination with PD-L1 Elicits Specific Anti-Tumor Immunity in Mice

Jiayi Pan, Wuyi Zeng, Jiangtao Jia, Yi Shi et autres

Dendritic cells (DCs), as professional antigen-presenting cells (APCs), play a key role in the initiation and regulation of humoral and cellular immunity. DC vaccines loaded with different tumor-associated antigens (TAAs) have been widely used to study their therapeutic effects on cancer. A …

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A Novel PD-L1-Containing MSLN Targeting Vaccine for Lung Cancer Immunotherapy

Wuyi Zeng, Jiayi Pan, Zixuan Fang, Jiangtao Jia et autres

Therapeutic tumor vaccines have become an important breakthrough in the treatment of various solid tumors including lung cancer. Dendritic cells (DCs)-based tumor vaccines targeting tumor-associated antigens (TAAs) play a key role in immunotherapy and immunoprevention. However, the weak immunogenicity of TAAs and …

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A Novel PD-L1-Containing MSLN Targeting Vaccine Elicits Therapeutic Antitumor Immunity in Mice

Wuyi Zeng, Jiayi Pan, Maoping Huang, Zixuan Fang et autres

Abstract Therapeutic tumor vaccines have become an important breakthrough in the treatment of various solid tumors including lung cancer. Dendritic cells (DCs)-based tumor vaccines targeting tumor-associated antigens (TAAs) play a key role in immunotherapy and immunoprevention. However, the weak immunogenicity of TAAs …

cn (code pays fourni par la source)