Ushashi Banerjee

CDK12/13 inhibition disrupts nucleolar morphology and promotes aberrant expression of IGS transcripts

Rodolfo Bortolozo Serafim, Marina P. Volegova, Matt L. Harlow, Ushashi Banerjee et autres

The transcription-associated cyclin dependent kinases (CDKs) 12 and 13 play important roles in the expression of RNAs involved in DNA damage repair and ribosomal proteins, yet their roles if any, in the regulation of ribosomal DNA expression are unclear. Here we show …

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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

Marina P. Volegova, Lauren E. Brown, Ushashi Banerjee, Ruben Dries et autres

Tumor MYCN amplification is seen in high-risk neuroblastoma, yet direct targeting of this oncogenic transcription factor has been challenging. Here, we take advantage of the dependence of MYCN-amplified neuroblastoma cells on increased protein synthesis to inhibit the activity of eukaryotic translation initiation …

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Inhibition of leukotriene‐B4 signalling‐mediated host response to tuberculosis is a potential mode of adjunctive host‐directed therapy

Ushashi Banerjee, Salik Miskat Borbora, Madhura Guha, Vikas Yadav et autres

Treatment of tuberculosis (TB) is faced with several challenges including the long treatment duration, drug toxicity and tissue pathology. Host-directed therapy provides promising avenues to find compounds for adjunctively assisting antimycobacterials in the TB treatment regimen, by promoting pathogen eradication or limiting …

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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

Marina P. Volegova, Lauren E. Brown, Ushashi Banerjee, Ruben Dries et autres

Abstract Tumor cell amplification of the MYCN transcription factor is seen in half of patients with high-risk neuroblastoma, where it functions as an oncogenic driver associated with metastatic disease and poor survival. Yet, direct targeting of MYCN has been met with little …

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Cysteine desulfurase (IscS)–mediated fine-tuning of bioenergetics and SUF expression prevents Mycobacterium tuberculosis hypervirulence

Mayashree Das, Sreesa Sreedharan, Somnath Shee, Nitish Malhotra et autres

Iron-sulfur (Fe-S) biogenesis requires multiprotein assembly systems, SUF and ISC, in most prokaryotes. M. tuberculosis ( Mtb ) encodes a complete SUF system, the depletion of which was bactericidal. The ISC operon is truncated to a single gene iscS (cysteine desulfurase), whose …

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PathTracer Comprehensively Identifies Hypoxia-Induced Dormancy Adaptations in Mycobacterium tuberculosis

Ushashi Banerjee, Adithya Chedere, Raksha Padaki, Abhilash Mohan et autres

Mining large-scale data to discover biologically relevant information remains a challenge despite the rapid development of bioinformatics tools. Here, we have developed a new tool, PathTracer, to identify biologically relevant information flows by mining genome-wide protein–protein interaction networks following integration of gene …

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Systems-level profiling of early peripheral host-response landscape variations across COVID-19 severity states in an Indian cohort

Ushashi Banerjee, Sneha K. Chunchanur, R. Ambica, Kithiganahalli Narayanaswamy Balaji et autres

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Pressured cytotoxic T cell epitope strength among SARS‐CoV ‐2 variants correlates with COVID ‐19 severity

Vishal N. Rao, Ushashi Banerjee, Narmada Sambaturu, Sneha K. Chunchanur et autres

Heterogeneity in susceptibility among individuals to COVID-19 has been evident through the pandemic worldwide. Cytotoxic T lymphocyte (CTL) responses generated against pathogens in certain individuals are known to impose selection pressure on the pathogen, thus driving emergence of new variants. In this …

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A 9-gene biomarker panel identifies bacterial coinfections in culture-negative COVID-19 cases

Ushashi Banerjee, P. Sreedhar Rao, Megha Reddy, Meeran Hussain et autres

Confirmatory diagnosis of bacterial coinfections with COVID-19 is challenging due to the limited specificity of the widely used gold-standard culture sensitivity test despite clinical presentations. A misdiagnosis can either lead to increased health complications or overuse of antibiotics in COVID-19 patients. With …

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Predicted CTL responses from pressured epitopes in SARS-CoV-2 correlate with COVID-19 severity

Vishal N. Rao, Ushashi Banerjee, Narmada Sambaturu, Sneha K. Chunchanur et autres

Abstract Heterogeneity in susceptibility among individuals to COVID-19 has been evident through the pandemic worldwide. Protective cytotoxic T lymphocyte (CTL) responses generated against pathogens in certain individuals are known to impose selection pressure on the pathogen, thus driving emergence of new variants. …

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VB10, a new blood biomarker for differential diagnosis and recovery monitoring of acute viral and bacterial infections

Sathyabaarathi Ravichandran, Ushashi Banerjee, Gayathri Devi, Rooparani Kandukuru et autres

Background Precise differential diagnosis between acute viral and bacterial infections is important to enable appropriate therapy, avoid unnecessary antibiotic prescriptions and optimize the use of hospital resources. A systems view of host response to infections provides opportunities for discovering sensitive and robust …

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Immune Subtyping in Latent Tuberculosis

Ushashi Banerjee, Priyanka Baloni, Amit Singh, Nagasuma R Chandra

Latent tuberculosis infection (LTBI) poses a major roadblock in the global effort to eradicate tuberculosis (TB). A deep understanding of the host responses involved in establishment and maintenance of TB latency is required to propel the development of sensitive methods to detect …

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