Marina P. Volegova

CDK12/13 inhibition disrupts nucleolar morphology and promotes aberrant expression of IGS transcripts

Rodolfo Bortolozo Serafim, Marina P. Volegova, Matt L. Harlow, Ushashi Banerjee et autres

The transcription-associated cyclin dependent kinases (CDKs) 12 and 13 play important roles in the expression of RNAs involved in DNA damage repair and ribosomal proteins, yet their roles if any, in the regulation of ribosomal DNA expression are unclear. Here we show …

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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

Marina P. Volegova, Lauren E. Brown, Ushashi Banerjee, Ruben Dries et autres

Tumor MYCN amplification is seen in high-risk neuroblastoma, yet direct targeting of this oncogenic transcription factor has been challenging. Here, we take advantage of the dependence of MYCN-amplified neuroblastoma cells on increased protein synthesis to inhibit the activity of eukaryotic translation initiation …

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The MYCN 5′ UTR as a therapeutic target in neuroblastoma

Marina P. Volegova, Lauren E. Brown, Ushashi Banerjee, Ruben Dries et autres

Abstract Tumor cell amplification of the MYCN transcription factor is seen in half of patients with high-risk neuroblastoma, where it functions as an oncogenic driver associated with metastatic disease and poor survival. Yet, direct targeting of MYCN has been met with little …

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The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs

Marina P. Volegova, Cynthia Hermosillo, Jamie H. D. Cate

Improper regulation of translation initiation, a vital checkpoint of protein synthesis in the cell, has been linked to a number of cancers. Overexpression of protein subunits of eukaryotic translation initiation factor 3 (eIF3) is associated with increased translation of mRNAs involved in …

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Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma

Yang Gao, Marina P. Volegova, Nicole M. Nasholm, Sanjukta Das et autres

Purpose Cyclin-dependent kinases (CDKs) that have critical roles in RNA polymerase II (Pol II)-mediated gene transcription are emerging as therapeutic targets in cancer. We have previously shown that THZ1, a covalent inhibitor of CDKs 7/12/13, leads to cytotoxicity in MYCN-amplified neuroblastoma through …

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The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs

Marina P. Volegova, Cynthia Hermosillo, Jamie H. D. Cate

ABSTRACT Improper regulation of translation initiation, a vital checkpoint of protein synthesis in the cell, has been linked to a number of cancers. Overexpression of protein subunits of eukaryotic translation initiation factor 3 (eIF3) is associated with increased translation of mRNAs involved …

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Use of 16S rRNA Gene for Identification of a Broad Range of Clinically Relevant Bacterial Pathogens

Ramya Srinivasan, Ulaş Karaöz, Marina P. Volegova, Joanna K. MacKichan et autres

According to World Health Organization statistics of 2011, infectious diseases remain in the top five causes of mortality worldwide. However, despite sophisticated research tools for microbial detection, rapid and accurate molecular diagnostics for identification of infection in humans have not been extensively …

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Use of 16S rRNA gene for identification of a broad range of clinically relevant bacterial pathogens - eScholarship

Susan V. Lynch, R. Srinivasan, Ulaş Karaöz, Marina P. Volegova et autres

© 2015 PLOS ONE.According to World Health Organization statistics of 2011, infectious diseases remain in the top five causes of mortality worldwide. However, despite sophisticated research tools for microbial detection, rapid and accurate molecular diagnos