Tobias Wolfram

Preclinical evaluation of patient-specific 3D-printed PDLLA/SrHAp implants in a minipig segmental mandibular defect model

Christian Bräuer, Elisabeth Jarmer, Anja Lode, Tatjana Fecht et autres

Large segmental mandibular defects remain difficult to reconstruct, and patient-specific biodegradable scaffolds produced by additive manufacturing may offer an alternative to permanent alloplastic implants. This exploratory study evaluated three 3D-printed poly(DL-lactide) (PDLLA)-based implant configurations in a periosteum-preserving minipig mandibular defect model: PDLLA, …

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Biphasic Bone Implants through Hybrid Extrusion Printing of Thermoplastic Poly(lactic- co -glycolic) acid and Strontium-Modified Calcium Phosphate Bone Cement

Max von Witzleben, Tilman Ahlfeld, Richard Frank Richter, Anna-Maria Placht et autres

-glycolide) (PLLA-PGA) were successfully fabricated using an optimized extrusion-based 3D printing and postprocessing protocol. Degradation studies in water showed that the presence of the SrCPC phase in the biphasic scaffolds buffered the acidic degradation products of PLLA-PGA, delaying and attenuating the pH …

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Bone Regeneration in SLS-Manufactured Resorbable 3D-Scaffolds—An Experimental Pilot Study in Minipigs

Philipp Kauffmann, Susanne Wolfer, Tim Gellhaus, Christina Behrens et autres

Background: The aim of this experimental pilot study was to evaluate the effect of pore volume and material composition on bone ingrowth into a resorbable poly-L-lactide-CaCO3/CaP scaffold. Methods: Cylindric scaffolds of 7 mm diameter and 5 mm height and two different degrees …

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Bone Regeneration in SLS Manufactured Resorbable 3D- Scaffolds – An Experimental Pilot Study in Minipigs

Philipp Kauffmann, Susanne Wolfer, Christina Behrens, Tobias Wolfram et autres

Aim: The aim of this experimental pilot study was to evaluate the effect of pore volume and material composition on bone ingrowth into a resorbable poly-L-lactide-CaCO3 / CaP scaffold. Materials and Methods: Scaffolds with 35.9 and 41.1% porosity were produced through selective …

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Poly(dl-lactide) Polymer Blended with Mineral Phases for Extrusion 3D Printing—Studies on Degradation and Biocompatibility

Corina Vater, Christian Bräuer, Stefanie Grom, Tatjana Fecht et autres

A promising therapeutic option for the treatment of critical-size mandibular defects is the implantation of biodegradable, porous structures that are produced patient-specifically by using additive manufacturing techniques. In this work, degradable poly(DL-lactide) polymer (PDLLA) was blended with different mineral phases with the …

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In Vitro Coculture of Primary Human Cells to Analyze Angiogenesis, Osteogenesis, and the Inflammatory Response to Newly Developed Osteosynthesis Material for Pediatric Maxillofacial Traumatology: A Potential Pretesting Model before In Vivo Experiments

Eva Dohle, Tatjana Fecht, Tobias Wolfram, Frank Reinauer et autres

During the present study, an in vitro coculture bone tissue mimic based on primary osteoblasts and primary endothelial cells was used for a complex and broad evaluation of a newly developed material for applications in pediatric maxillofacial traumatology. The biomaterial was composed …

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A comparative analysis of 3D printed scaffolds consisting of poly(lactic- co -glycolic) acid and different bioactive mineral fillers: aspects of degradation and cytocompatibility

Tilman Ahlfeld, Anja Lode, Anna-Maria Placht, Tatjana Fecht et autres

. Cell culture experiments with the human osteosarcoma cell line SAOS-2 and human dental pulp stem cells (hDPSC) indicated the high cytocompatibility of the composites: For all material groups cell spreading and complete colonization of the scaffolds over the culture period of …

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Do-files for working with SOEP spell data

Maik Hamjediers, Paul Schmelzer, Tobias Wolfram

The measurement of labor market entries with SOEP data: Introduction to the variable EINSTIEG_ARTK

Marco Gießelmann, Paul Schmelzer, Mila Staneva, Tobias Wolfram

The variable EINSTIEG_ARTK in the file BIOJOB indicates the wave of a first labor market entry. The variable refers to the entry into the labor market after the completion of education and apprenticeship. Since we account for all kinds of employment (full-time, …

Nanostructured biofunctionalized polyurethanes for applications in regenerative medicine

Sebastian Kruss, Tobias Wolfram

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Fabrication of multi-parametric platforms based on nanocone arrays for determination of cellular response

Lindarti Purwaningsih, Tobias Schoen, Tobias Wolfram, Claudia Pacholski et autres

Cellular response to both surface topography and surface chemistry has been studied for several years. However, most of the studies focus on only one of the two parameters and do not consider their possible synergistic effects. Here, we report on a fabrication …

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Stimulation of Cell Adhesion at Nanostructured Teflon Interfaces

Sebastian Kruss, Tobias Wolfram, Raquel Martin, Stefanie Neubauer et autres

Tunable gold nanoparticle patterns have been immobilized onto amorphous teflon surfaces in a stable manner. This method provides a general route to covalently link biomolecules onto chemically inert teflon surfaces, which enhances endothelialization.

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