Tilman Ahlfeld

Biphasic Bone Implants through Hybrid Extrusion Printing of Thermoplastic Poly(lactic- co -glycolic) acid and Strontium-Modified Calcium Phosphate Bone Cement

Max von Witzleben, Tilman Ahlfeld, Richard Frank Richter, Anna-Maria Placht et autres

-glycolide) (PLLA-PGA) were successfully fabricated using an optimized extrusion-based 3D printing and postprocessing protocol. Degradation studies in water showed that the presence of the SrCPC phase in the biphasic scaffolds buffered the acidic degradation products of PLLA-PGA, delaying and attenuating the pH …

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Uniting 4D Printing and Melt Electrowriting for the Enhancement of Regenerative Small Diameter Vascular Grafts

Max von Witzleben, Akvilė Gasiūnaitė, Ashwini Rahul Akkineni, Kathleen Schütz et autres

The development of mechanically robust, cell-instructive, and seweable small-diameter (≤ Ø 6 mm) tubular scaffolds remain a major challenge in vascular tissue engineering. Here, a hybrid biofabrication strategy is presented that combines 4D printing of alginate-methylcellulose (AlgMC) hydrogels with melt electrowritten (MEW) …

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Poly(dl-lactide) Polymer Blended with Mineral Phases for Extrusion 3D Printing—Studies on Degradation and Biocompatibility

Corina Vater, Christian Bräuer, Stefanie Grom, Tatjana Fecht et autres

A promising therapeutic option for the treatment of critical-size mandibular defects is the implantation of biodegradable, porous structures that are produced patient-specifically by using additive manufacturing techniques. In this work, degradable poly(DL-lactide) polymer (PDLLA) was blended with different mineral phases with the …

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Biofabrication's Contribution to the Evolution of Cultured Meat

Franziska B. Albrecht, Tilman Ahlfeld, Annemarie Klatt, Simon Heine et autres

Cultured Meat (CM) is a growing field in cellular agriculture, driven by the environmental impact of conventional meat production, which contributes to climate change and occupies ≈70% of arable land. As demand for meat alternatives rises, research in this area expands. CM …

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How biofabrication can accelerate cultured meat’s path to market

Simon Heine, Tilman Ahlfeld, Franziska B. Albrecht, Michael Gelinsky et autres

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On the reproducibility of extrusion-based bioprinting: round robin study on standardization in the field

David Grijalva Garces, Svenja Strauß, Sarah Gretzinger, Barbara Schmieg et autres

The outcome of three-dimensional (3D) bioprinting heavily depends, amongst others, on the interaction between the developed bioink, the printing process, and the printing equipment. However, if this interplay is ensured, bioprinting promises unmatched possibilities in the health care area. To pave the …

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Multimodal additive manufacturing of biomimetic tympanic membrane replacements with near tissue-like acousto-mechanical and biological properties

Max von Witzleben, Thomas Stoppe, Alina Zeinalova, Kai Chen et autres

The three additive manufacturing techniques fused deposition modeling, gel plotting and melt electrowriting were combined to develop a mimicry of the tympanic membrane (TM) to tackle large TM perforations caused by chronic otitis media. The mimicry of the collagen fiber orientation of …

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Treatment of critical bone defects using calcium phosphate cement and mesoporous bioactive glass providing spatiotemporal drug delivery

Richard Frank Richter, Corina Vater, Margarete Korn, Tilman Ahlfeld et autres

Calcium phosphate cements (CPC) are currently widely used bone replacement materials with excellent bioactivity, but have considerable disadvantages like slow degradation. For critical-sized defects, however, an improved degradation is essential to match the tissue regeneration, especially in younger patients who are still …

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Egg white improves the biological properties of an alginate-methylcellulose bioink for 3D bioprinting of volumetric bone constructs

Suihong Liu, David Kilian, Tilman Ahlfeld, Qingxi Hu et autres

Three-dimensional microextrusion bioprinting has attracted great interest for fabrication of hierarchically structured, functional tissue substitutes with spatially defined cell distribution. Despite considerable progress, several significant limitations remain such as a lack of suitable bioinks which combine favorable cell response with high shape …

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Multimodal Additive Manufacturing of Biomimetic Tympanic Membrane Replacements with Near Tissue-Like Acousto-Mechanical and Biological Properties

Max von Witzleben, Thomas Stoppe, Alina Zeinalova, Zhaoyu Chen et autres

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A comparative analysis of 3D printed scaffolds consisting of poly(lactic- co -glycolic) acid and different bioactive mineral fillers: aspects of degradation and cytocompatibility

Tilman Ahlfeld, Anja Lode, Anna-Maria Placht, Tatjana Fecht et autres

. Cell culture experiments with the human osteosarcoma cell line SAOS-2 and human dental pulp stem cells (hDPSC) indicated the high cytocompatibility of the composites: For all material groups cell spreading and complete colonization of the scaffolds over the culture period of …

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Evaluation of an Injectable Biphasic Calcium Sulfate/Hydroxyapatite Cement for the Augmentation of Fenestrated Pedicle Screws in Osteoporotic Vertebrae: A Biomechanical Cadaver Study

Xinggui Tian, Deepak Raina, Corina Vater, David Kilian et autres

Cement augmentation of pedicle screws is one of the most promising approaches to enhance the anchoring of screws in the osteoporotic spine. To date, there is no ideal cement for pedicle screw augmentation. The purpose of this study was to investigate whether …

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