Accès ouvert
2026
review
OpenAlex
Nike Walter, Christoph Brochhausen, Thaqif El Khassawna, Corina Vater et autres
BACKGROUND: Localized biofilm-associated infections remain difficult to treat with systemic antibiotics amid rising resistance. Hydrogel delivery may enhance bacteriophage (phage) therapy by protecting phages, prolonging residence, and enabling controlled release. This systematic review summarizes in vivo evidence for hydrogel-mediated phage delivery and …
de, li, hk
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Johannes Windisch, Max von Witzleben, Richard Frank Richter, Sophie Dani et autres
ABSTRACT Extrusion bioprinting is a promising tool for autonomous medical care and biomanufacturing during long‐duration crewed space missions. However, the implementation of this technology depends on how cell‐laden bioinks can be brought to the space platform without compromising their biological functionality. In …
de
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Christian Bräuer, Elisabeth Jarmer, Anja Lode, Tatjana Fecht et autres
Large segmental mandibular defects remain difficult to reconstruct, and patient-specific biodegradable scaffolds produced by additive manufacturing may offer an alternative to permanent alloplastic implants. This exploratory study evaluated three 3D-printed poly(DL-lactide) (PDLLA)-based implant configurations in a periosteum-preserving minipig mandibular defect model: PDLLA, …
de
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Max von Witzleben, Tilman Ahlfeld, Richard Frank Richter, Anna-Maria Placht et autres
-glycolide) (PLLA-PGA) were successfully fabricated using an optimized extrusion-based 3D printing and postprocessing protocol. Degradation studies in water showed that the presence of the SrCPC phase in the biphasic scaffolds buffered the acidic degradation products of PLLA-PGA, delaying and attenuating the pH …
de
(code pays fourni par la source)
Accès ouvert
2026
review
OpenAlex
Johannes Windisch, Csaba Gergely, Maximilian Pfeiffle, Lisa Galaba et autres
Microalgae are robust microorganisms with versatile metabolic functions, including oxygen generation, making them crucial components in wastewater treatment plants, food production, or extraterrestrial life-support systems. Immobilizing microalgae in hydrogels could eliminate costly separation steps required in free-floating cultivation. Volumetric bioprinting (VBP), enabling …
de
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Sophie Dani, Sarah Duin, Ashwini Rahul Akkineni, Susann Lehmann et autres
Type 1 diabetes mellitus (T1D) is characterized by the autoimmune destruction of pancreatic beta cells, leading to insulin deficiency and necessitating lifelong external insulin administration. The transplantation of allogenic islets is a promising therapeutic approach, whereby their macro-encapsulation offers immune protection but …
de, dk
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Leonie Schlicht, Johannes Jähnichen, Richard Frank Richter, Michael Gelinsky et autres
To achieve bone regeneration in critical size defects, filling of the defect either with autologous bone or with a biodegradable bone substitute material possessing osteoconductivity and osteoinductivity is required. Biomimetically mineralized collagen is a nanocomposite material that closely resembles the natural bone …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Sophie Dani, Nieves Cubo‐Matteo, Leonie Schlicht, Michael Gelinsky et autres
Combining the volumetric fabrication of hydrogel constructs using extrusion bioprinting with highly precise drop-on-demand (DoD) bioprinting offers exciting opportunities in biofabrication. This technical report presents a technique in which a solenoid micro-pipette is operated as an additional tool in an extrusion (bio)printing …
de, es
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Johannes Windisch, Richard Frank Richter, Kristina Beblo‐Vranesevic, Kaja Sophie Grewe et autres
Abstract Bioprinting, a technology with the potential to support long-term space missions, offers medical solutions for human settlements on the Moon and Mars. Moreover, ‘green bioprinting’ presents a promising approach to address terrestrial environmental challenges. Effective and cost-efficient implementation of this technology …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Corina Vater, Gopala Krishna Mannala, Max von Witzleben, Richard Frank Richter et autres
Multiple drug-resistant bacteria are a growing life-threatening problem and novel treatment strategies are urgently needed. One promising option is the use of lytic bacteriophages, viruses that infect and kill bacteria with high specificity. To efficiently utilize bacteriophage therapy for the treatment of …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Max von Witzleben, Akvilė Gasiūnaitė, Ashwini Rahul Akkineni, Kathleen Schütz et autres
The development of mechanically robust, cell-instructive, and seweable small-diameter (≤ Ø 6 mm) tubular scaffolds remain a major challenge in vascular tissue engineering. Here, a hybrid biofabrication strategy is presented that combines 4D printing of alginate-methylcellulose (AlgMC) hydrogels with melt electrowritten (MEW) …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Richard Frank Richter, Frank Pries, Volker Alt, Anja Lode et autres
Calcium phosphate cements (CPC) are widely used materials for filling bone defects and bone augmentation. Developments in CPC formulations have led to a practically unlimited processability, allowing to use these formulations for new fabrication methods like extrusion-based 3D-printing. This study shows the …
de
(code pays fourni par la source)