Frank Reinauer

One-year clinical and radiographic outcomes of alveolar bone regeneration using 3D-printed β-tricalcium phosphate biomaterials for single implant rehabilitation: A retrospective study

Carlo Mangano, Henriette Lerner, Adem Aksu, Frank Reinauer et autres

OBJECTIVES: To evaluate the one-year clinical and radiographic outcomes of single implant rehabilitation performed following alveolar ridge regeneration using 3D-printed β-tricalcium phosphate (β-TCP) biomaterials applied according to three different regenerative protocols. METHODS: Thirty consecutive patients requiring localized alveolar ridge augmentation before or …

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Preclinical evaluation of patient-specific 3D-printed PDLLA/SrHAp implants in a minipig segmental mandibular defect model

Christian Bräuer, Elisabeth Jarmer, Anja Lode, Tatjana Fecht et autres

Large segmental mandibular defects remain difficult to reconstruct, and patient-specific biodegradable scaffolds produced by additive manufacturing may offer an alternative to permanent alloplastic implants. This exploratory study evaluated three 3D-printed poly(DL-lactide) (PDLLA)-based implant configurations in a periosteum-preserving minipig mandibular defect model: PDLLA, …

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Reconstruction of critical-sized mandibular defects in a sheep model using a PLLA-PGA-CC scaffold

Katharina Pippich, Vincent Vitus Klett, Adem Aksu, Frank Reinauer et autres

Abstract Introduction Critical-sized bone defects cannot heal spontaneously, requiring additional, often burdensome, treatment. Thus, various synthetic substitute materials have been investigated regarding their treatment capacity. Poly-L-lactic acid (PLLA) and polyglycolic acid (PGA) have emerged as promising biodegradable scaffold materials. The addition of …

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Verbundprojekt: Funktionalisierte Kompositwerkstoffe auf Basis von UHMWPE für die generative Fertigung bioaktiver patientenindividueller Implantatsysteme; Teilvorhaben: Fertigungsverfahren und Produktionstechnik für funktions- und stabilitätsoptimierte Implantatstrukturen

Frank Reinauer, Adem Aksu, Lena Schaarschmidt, Tatjana Fecht et autres

Ziel des Verbundvorhabens BioActivePOR war die Entwicklung funktionalisierter Kompositwerkstoffe auf Basis von UHMWPE (Ultra-High-Molecular-Weight Polyethylene) sowie deren Über- führung in ein additives Fertigungsverfahren zur Herstellung bioaktiver, antibakteriell wirkender, patientenindividueller Implantate, insbesondere für die Knochenrekonstruktion im kraniomaxillofazialen Bereich. UHMWPE ist seit Jahrzehnten als …

Biphasic Bone Implants through Hybrid Extrusion Printing of Thermoplastic Poly(lactic- co -glycolic) acid and Strontium-Modified Calcium Phosphate Bone Cement

Max von Witzleben, Tilman Ahlfeld, Richard Frank Richter, Anna-Maria Placht et autres

-glycolide) (PLLA-PGA) were successfully fabricated using an optimized extrusion-based 3D printing and postprocessing protocol. Degradation studies in water showed that the presence of the SrCPC phase in the biphasic scaffolds buffered the acidic degradation products of PLLA-PGA, delaying and attenuating the pH …

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Cranial Defect Reconstruction With Custom 3D‐Printed Hydroxyapatite Scaffolds Augmented With rhBMP‐2 or Dipyridamole in a Nonhuman Primate Model

Griffin Patrick Bins, Heather A. Burkart, William Molair, Samuel Kogan et autres

Objective Reconstruction of critical‐sized bone defects, particularly in the cranio‐maxillofacial region, presents unique challenges due to the need for integration with adjacent well‐vascularized tissue and the absence of significant load‐bearing requirements. This study evaluated the clinical readiness of bone tissue engineering (BTE) …

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Bone Regeneration in SLS-Manufactured Resorbable 3D-Scaffolds—An Experimental Pilot Study in Minipigs

Philipp Kauffmann, Susanne Wolfer, Tim Gellhaus, Christina Behrens et autres

Background: The aim of this experimental pilot study was to evaluate the effect of pore volume and material composition on bone ingrowth into a resorbable poly-L-lactide-CaCO3/CaP scaffold. Methods: Cylindric scaffolds of 7 mm diameter and 5 mm height and two different degrees …

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Advantages of digital twin technology in orthopedic trauma Surgery – Exploring different clinical use cases

Annchristin Andres, Michael Roland, Kerstin Wickert, Stefan Diebels et autres

Digital twin technology offers significant benefits for addressing fracture non-unions in orthopedic trauma surgery, particularly in cases requiring revision surgery. In this study, we developed a clinically applicable digital twin workflow that integrates patient-specific imaging, motion capture, musculoskeletal modeling, and finite element …

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In Vivo Inflammatory Soft and Hard Tissue Response to Newly Developed Osteosynthesis Material for Pediatric Maxillofacial Traumatology in a Critical Size Bone Defect Model

Anja Heselich, Eva Dohle, Mihaela Felicia Băciuț, Cristian Mihail Dinu et autres

Childhood trauma defects in the head and neck area are challenging in many aspects for patients and surgeons. One major issue is the still incomplete growth. Bone defect fixation measures have to consider biomechanical forces due to the bone growth from both …

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Poly(dl-lactide) Polymer Blended with Mineral Phases for Extrusion 3D Printing—Studies on Degradation and Biocompatibility

Corina Vater, Christian Bräuer, Stefanie Grom, Tatjana Fecht et autres

A promising therapeutic option for the treatment of critical-size mandibular defects is the implantation of biodegradable, porous structures that are produced patient-specifically by using additive manufacturing techniques. In this work, degradable poly(DL-lactide) polymer (PDLLA) was blended with different mineral phases with the …

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In Vitro Coculture of Primary Human Cells to Analyze Angiogenesis, Osteogenesis, and the Inflammatory Response to Newly Developed Osteosynthesis Material for Pediatric Maxillofacial Traumatology: A Potential Pretesting Model before In Vivo Experiments

Eva Dohle, Tatjana Fecht, Tobias Wolfram, Frank Reinauer et autres

During the present study, an in vitro coculture bone tissue mimic based on primary osteoblasts and primary endothelial cells was used for a complex and broad evaluation of a newly developed material for applications in pediatric maxillofacial traumatology. The biomaterial was composed …

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Metallic Artifact Reduction in Midfacial CT Scans Using Patient-Specific Polymer Implants Enhances Image Quality

Julian Lommen, Lara Schorn, Christoph K. Sproll, Valentin Kerkfeld et autres

Midfacial reconstruction after tumor resection surgery is commonly conducted by using autologous bone grafts or alloplastic implants. Titanium is the most frequently used osteosynthesis material in these cases but causes disturbing metallic artifacts in CT imaging. The purpose of this experimental study …

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