Accès ouvert
2026
article
OpenAlex
Peiqi Yin, Sainan Wang, Michael R. Sirrine, Alexander Leach et autres
ABSTRACT Chikungunya virus (CHIKV) and other alphaviruses in the Togaviridae family are positive-sense RNA viruses and major human pathogens, causing millions of infections worldwide. In humans, alphaviruses such as CHIKV, Mayaro and Ross River viruses typically cause arthritogenic disease characterized by debilitating …
us, ee
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Carolin M. Lieber, Josef D. Wolf, Mugunthan Govindarajan, Jeong_Joong Yoon et autres
Orthoparamyxoviruses such as human parainfluenza virus type-3 (HPIV3), measles virus (MeV), and emerging henipaviruses pose a substantial threat to human health. We discovered an orally efficacious broad-spectrum non-nucleoside inhibitor of orthoparamyxovirus polymerases. However, here we found that tolerability in higher mammals was …
us
(code pays fourni par la source)
2022
article
OpenAlex
L.L. Hammitt, R. Dagan, Y. Yuan, M. Baca Cots et autres
(N Engl J Med. 2022;386:837–846. doi: 10.1056/NEJMoa2110275) Infants experience medically attended illness and hospitalization at elevated rates from respiratory syncytial virus (RSV) infection. As a monoclonal antibody with an extended half-life, Nirsevimab (N) is an emerging treatment that binds to the RSV …
us
(code pays fourni par la source)