Michael R. Sirrine

Identification and characterization of novel chikungunya virus polymerase inhibitors

Peiqi Yin, Sainan Wang, Michael R. Sirrine, Alexander Leach et autres

ABSTRACT Chikungunya virus (CHIKV) and other alphaviruses in the Togaviridae family are positive-sense RNA viruses and major human pathogens, causing millions of infections worldwide. In humans, alphaviruses such as CHIKV, Mayaro and Ross River viruses typically cause arthritogenic disease characterized by debilitating …

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Serial Adaptation of Viruses for Reduced Susceptibility Profiling

Michael R. Sirrine, Richard Karl Plemper

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Structural basis of paramyxo- and pneumovirus polymerase inhibition by non-nucleoside small-molecule antivirals

Josef D. Wolf, Michael R. Sirrine, Robert M. Cox, Richard Karl Plemper

Small-molecule antivirals can be used as chemical probes to stabilize transitory conformational stages of viral target proteins, facilitating structural analyses. Here, we evaluate allosteric pneumo- and paramyxovirus polymerase inhibitors that have the potential to serve as chemical probes and aid the structural …

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Genome Sequences of 12 Phages That Infect Klebsiella pneumoniae

Trever L. Thurgood, Ruchira Sharma, Jackson J. Call, Joshua D. Chronis et autres

Klebsiella pneumoniae is a pathogen responsible for significant proportions of nosocomial and health care-associated infections and is known to acquire multiple antibiotic resistance genes. Here, we announce the full genome sequences of 12 K. pneumoniae bacteriophages from samples collected in wastewater treatment …

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