Peiqi Yin

Identification and characterization of novel chikungunya virus polymerase inhibitors

Peiqi Yin, Sainan Wang, Michael R. Sirrine, Alexander Leach et autres

ABSTRACT Chikungunya virus (CHIKV) and other alphaviruses in the Togaviridae family are positive-sense RNA viruses and major human pathogens, causing millions of infections worldwide. In humans, alphaviruses such as CHIKV, Mayaro and Ross River viruses typically cause arthritogenic disease characterized by debilitating …

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Ultrasensitive and high-accuracy trace detection by using self-absorption-autocompensated discharge-assisted LIBS for reinforcing aircraft safety

Boping Xu, Peiqi Yin, Jiajia Hou, Xukun Yin et autres

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Time-resolved characteristics and self-absorption correction of laser-induced plasma in a transient electric field

Boping Xu, Peiqi Yin, Jiajia Hou, Jun Tang et autres

Transient electric field (TEF) assisted laser-induced plasma (LIP) is a simple, efficient, and low-cost method for plasma spectral enhancement. However, due to the self-absorption effect, the true spectral intensity is reduced, which poses difficulties in the diagnosis of the plasma parameters in …

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Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4′-Fluorouridine

Peiqi Yin, Elizabeth B. Sobolik, Nicholas May, Sainan Wang et autres

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that has re-emerged to cause large outbreaks of human infections worldwide. There are currently no approved antivirals for treatment of CHIKV infection. Recently, we reported that the ribonucleoside analog 4'-fluorouridine (4'-FlU) is a highly potent …

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Ultrasensitive and high-accuracy trace detection by using self-absorption-autocorrected discharge-assisted LIBS for reinforcing aircraft safety

Boping Xu, Peiqi Yin, Jiajia Hou, Xukun Yin et autres

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The alphavirus determinants of intercellular long extension formation

Caroline Martin, Judy J. Wan, Peiqi Yin, Thomas E. Morrison et autres

The alphavirus chikungunya virus (CHIKV) is a serious human pathogen that can cause large-scale epidemics characterized by fever and joint pain and often resulting in chronic arthritis. Infection by alphaviruses including CHIKV and the closely related Semliki Forest virus (SFV) can induce …

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The sticky business of Alphavirus capsid–host interactions

Caroline Martin, Peiqi Yin, Margaret Kielian

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Virus stealth technology: Tools to study virus cell-to-cell transmission

Peiqi Yin, Caroline Martin, Margaret Kielian

To successfully infect a cell, viruses must overcome the host's antiviral defenses including the adaptive immune response that produces antiviral antibodies.Many viruses have evolved strategies to infect even in the presence of neutralizing antibodies via a process of virus cell-to-cell transmission.These strategies …

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Numerical simulation of dynamics behavior of pulsed-DC helium plasma jet confined by parallel magnetic field at atmospheric pressure

Yinghua Liu, Peiqi Yin, Boping Xu, Dawei Liu et autres

A two-dimensional axisymmetric fluid model is used to simulate the dynamics behavior of an atmospheric-pressure helium plasma jet in the presence of a parallel magnetic field. The plasma jet is generated in a coaxial dielectric barrier discharge (DBD) driven by pulsed direct-current …

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4′-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo

Peiqi Yin, Nicholas May, Laura Sandra Lello, Atef Fayed et autres

ABSTRACT Chikungunya virus (CHIKV) is an enveloped, positive-sense RNA virus that has re-emerged to cause millions of human infections worldwide. In humans, acute CHIKV infection causes fever and severe muscle and joint pain. Chronic and debilitating arthritis and joint pain can persist …

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A single-point mutation in the rubella virus E1 glycoprotein promotes rescue of recombinant vesicular stomatitis virus

Pratyush Kumar Das, Paulina Alatriste González, Rohit K. Jangra, Peiqi Yin et autres

genus. RuV infection in pregnant women can lead to miscarriage or an array of severe birth defects known as congenital rubella syndrome. Novel rubiviruses were recently discovered in various mammals, highlighting the spillover potential of other rubiviruses to humans. Many features of …

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Simulation of evaporation ablation dynamics of materials by nanosecond pulse laser of Gaussian beam and flat-top beam

Peiqi Yin, Boping Xu, Yinghua Liu, Yishan Wang et autres

Based on the established two-dimensional asymmetric model of the interaction between a nanosecond pulse laser and metallic aluminum, the effect of beam shaping on the evaporation ablation dynamics during the ablation of metallic aluminum by a nanosecond pulse laser is simulated. The …