Sainan Wang

Effectiveness of WeChat Public Account Intervention Based on the Information-Motivation-Behavioral Skills Model Among College Students With Internet Addiction: Randomized Controlled Trial

Anyi Geng, Wenhua Ruan, Haiyan Shi, Wenzhuo Xu et autres

BACKGROUND Internet addiction (IA) among college students causes multiple harms and increases suicide risk. Effective interventions can reduce these and have public health value. OBJECTIVE This study evaluates a WeChat public-account intervention based on the information, motivation, behavioral skills (IMB) model to …

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Identification and characterization of novel chikungunya virus polymerase inhibitors

Peiqi Yin, Sainan Wang, Michael R. Sirrine, Alexander Leach et autres

ABSTRACT Chikungunya virus (CHIKV) and other alphaviruses in the Togaviridae family are positive-sense RNA viruses and major human pathogens, causing millions of infections worldwide. In humans, alphaviruses such as CHIKV, Mayaro and Ross River viruses typically cause arthritogenic disease characterized by debilitating …

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Sexualized Drug Use Linked to Higher HIV Testing Frequency Among Men Who Have Sex with Men in Three Chinese Cities with High HIV Prevalence

Danyang Luo, Sainan Wang, Xiuping Zhao, Zhizheng Huang et autres

BACKGROUND: Men who have sex with men (MSM) in China experience high HIV prevalence, yet little is known about the HIV testing behaviors of MSM among those who engage in sexualized drug use (SDU). Clarifying these patterns is essential for designing targeted …

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Trans-complementation of chikungunya virus replicase mutants reveals alphavirus replication complexity and supports antiviral tool development

Sainan Wang, Krystyna Naumenko, Mandana Mirzajani Sarvandani, Laura Sandra Lello et autres

Chikungunya virus (CHIKV) is a reemerging alphavirus responsible for large-scale outbreaks in tropical regions. Its RNA replication depends on the assembly of functional replication complexes using the P123 and P1234 polyprotein precursors and their cleavage products, the nonstructural proteins (nsP1-nsP4). To dissect …

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Multidisciplinary management of concurrent postpartum eclampsia, HELLP syndrome, ruptured hepatic subcapsular hematoma, and atypical hemolytic uremic syndrome: a case report

Sainan Wang, Haizhen Jiang, Qining Xing, Yan Xue et autres

BACKGROUND: The concurrent presentation of postpartum eclampsia, HELLP syndrome (hemolysis, elevated liver enzymes, low platelets), ruptured hepatic subcapsular hematoma, and pregnancy-associated atypical hemolytic uremic syndrome (P-aHUS) represents a life-threatening obstetric emergency. To the best of our knowledge, this represents a novel presentation, …

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DHHC enzymes in alphavirus glycoprotein acylation: A target for broad-spectrum antiviral therapy

Xiaoling Li, Wanjie Song, Zhiwen Jiang, Yunbiao Lu et autres

Alphaviruses are mosquito-transmitted viruses that cause severe zoonotic diseases. Their envelope glycoproteins, E1 and E2, undergo cysteine acylation, a process critical for virus infection but previously undefined mechanistically. Using the Getah virus as a model, we found that E1 is acylated at …

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A conserved long-range RNA interaction in SARS-CoV-2 recruits ADAR1 to enhance virus proliferation

Siwy Ling Yang, Louis DeFalco, Sainan Wang, Yi Hao Wong et autres

Long-range RNA-RNA pairing impacts the genome structure and function of SARS-CoV-2 variants. To understand the structure and function relationships of different SARS-CoV-2 variants that have emerged during the COVID-19 pandemic, we perform high-throughput structure probing and modelling of the genomic structures of …

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Construction and application of home dietary management program for postoperative patients with preventive ileostomy for rectal cancer

Jianhua Zhu, Yang Shen, Juyun Li, Sainan Wang et autres

Background Rectal cancer is a highly prevalent malignant tumor, and surgery is one of the main treatment methods. Although preventive ileostomy can reduce postoperative complications, it is also prone to cause malnutrition and other problems. Objective To construct and validate an early …

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Efficacy of a WeChat Public Account-based intervention for problematic smartphone use among Chinese undergraduate students: A randomized controlled trial (Preprint)

Zhihua Zhang, Sainan Wang, Wenzhuo Xu, Kele Jiang et autres

BACKGROUND Problematic smartphone use (PSU) among Chinese undergraduate students has become a significant public health concern. This study sought to develop a targeted preventive intervention for PSU, grounded in the Information-Motivation-Behavioral Skills (IMB) model and delivered through WeChat official accounts. OBJECTIVE This …

A conserved long-range RNA interaction in SARS-CoV-2 recruits ADAR1 to enhance virus proliferation

Siwy Ling Yang, Louis DeFalco, Sainan Wang, Yi Hao Wong et autres

ABSTRACT Long-range RNA-RNA pairing impacts the genome structure and function of SARS-CoV-2 variants. To understand the structure and function relationships of different SARS-CoV-2 variants that have emerged during the COVID-19 pandemic, we performed high-throughput structure probing and modelling of the genomic structures …

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Effectiveness of Digital Health Interventions in Promoting the Pre-Exposure Prophylaxis (PrEP) Care Continuum among Men who Have Sex With Men (MSM): A Systematic Review of Randomized Controlled Trials

Jun Du, Guifang Jin, Hongbo Zhang, Don Operario et autres

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Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti‐Alphavirus Therapies

Sainan Wang, Suresh Mahalingam, Andres Merits

Alphaviruses are re-emerging vector-born pathogens that cause arthralgia or encephalitic diseases on a global scale. While a vaccine against chikungunya virus was recently approved, no vaccines currently exist for other alphaviruses, nor are there antiviral drugs for the treatment of alphavirus infections. …

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