Clara Lima

Integrating Ecotoxicity into Early-Stage Drug Development for Parasitic Diseases: A One Health Position Paper

Theo Zacharis, Sheraz Gul, Bruno Nunes, Paul M. Selzer et autres

Vector-borne parasitic diseases (VBDs), including leishmaniasis, trypanosomiases, schistosomiasis and babesiosis, pose an escalating threat to human and animal health across Europe and globally. Approximately 75% of emerging human infections originate from animals, and VBDs account for roughly 17% of the global infectious …

gr, de, pt, gb, es, be, us, it (code pays fourni par la source)

Integrating Ecotoxicity into Early-Stage Drug Development for Parasitic Diseases: A One Health Position Paper

Theo Zacharis, Sheraz Gul, Bruno Nunes, Paul M. Selzer et autres

Vector-borne parasitic diseases (VBDs), including leishmaniasis, trypanosomiases, schistosomiasis and babesiosis, pose an escalating threat to human and animal health across Europe and globally. Approximately 75% of emerging human infections originate from animals, and VBDs account for roughly 17% of the global infectious …

gr, de, pt, gb, es, be, us, it (code pays fourni par la source)

Strategic surveillance plan for zoonotic leishmaniosis in Portugal

Clara Lima, Luı́s Cardoso, Joana Tavares, Mariana Portugal et autres

One-year efficacy of Dupilumab in sense of smell, nasal polyp score and quality of life in CRSwNP patients: A real-world multicenter study in Brazil

Otávio Marana Mieli, Fabiana Cardoso Pereira Valera, Vanessa Ramos Pires Dinarte, Clara Lima et autres

OBJECTIVE: To present the outcomes of dupilumab in olfactory function, Nasal Polyp Score (NPS) and quality of life in Brazilian patients with severe CRSwNP. METHODS: We selected severe type 2 CRSwNP patients from different Brazilian centers. Dupilumab was indicated after failure of …

br (code pays fourni par la source)

Dirofilaria spp. infection in cats from the Mediterranean basin: diagnosis and epidemiology

Mariaelisa Carbonara, Lívia Perles, Simona Gabrielli, Vanessa R. Barrs et autres

• We provide updates on the epidemiology of feline dirofilariosis in the Mediterranean basin. • Overall, 3.8% (i.e., 41/1,083) of cats scored positive for Dirofilaria spp. • Dirofilaria immitis mainly circulates in cats from Mediterranean islands. • Nematode positivity was statistically associated …

it, hk, es, vn, gr, pt, fr, il, de, us (code pays fourni par la source)

Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use

Clara Lima, Elisa Uliassi, Eli S.J. Thoré, Michael G. Bertram et autres

Background: The current scientific discourse on environmental impacts of veterinary medicines mostly focuses on ectoparasiticides. Meanwhile, the environmental impacts of widely prescribed drugs for the treatment of human and animal parasitic vector-borne diseases (PVBD) remain largely unexplored. There is thus a need …

pt, it, be, se, au, gb (code pays fourni par la source)

Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use

Clara Lima, Elisa Uliassi, Eli S.J. Thoré, Michael G. Bertram et autres

Background The current scientific discourse on environmental impacts of veterinary medicines mostly focuses on ectoparasiticides. Meanwhile, the environmental impacts of widely prescribed drugs for the treatment of human and animal parasitic vector-borne diseases (PVBD) remain largely unexplored. There is thus a need …

Veterinary perspectives on the urbanization of leishmaniosis in Morocco

Clara Lima, Maria Bourquia, Abderrahmane Zahri, Nada Haissen et autres

BACKGROUND: Leishmaniosis caused by Leishmania infantum, L. major and L. tropica is endemic in Morocco. Growing evidence of both human and canine Leishmania infections in urban centres has been reported. Since many forms of the disease are zoonotic, veterinarians play an important …

pt, Maroc (code pays fourni par la source)

Feline leishmaniosis in the Mediterranean Basin: a multicenter study

Mariaelisa Carbonara, Roberta Iatta, Guadalupe Miró, Ana Montoya et autres

BACKGROUND: Cats are now recognized as competent hosts for Leishmania infantum and a blood source for sand fly vectors. Although canine leishmaniosis (CanL) is endemic in Mediterranean Basin countries, large-scale epidemiological studies are lacking for feline leishmaniosis (FeL). This study aimed to …

it, es, gr, pt, fr, il, hk (code pays fourni par la source)

Data collection on research perspectives for drug development targeting vectorborne diseases and environmental impact

Harry P. de Koning, Clara Lima

gb, pt (code pays fourni par la source)

Hepatozoon species infecting domestic cats from countries of the Mediterranean basin

Mariaelisa Carbonara, Roberta Iatta, Giovanni Sgroi, Elias Papadopoulos et autres

Tick-borne diseases (TBDs) are caused by pathogens of human and veterinary concern representing a major public health issue worldwide. Although feline medicine has progressed much in the recent decades, data on feline TBDs (FeTBDs) remain scant. Therefore, this study aimed to assess …

it, gr, pt, fr, es, il, ir (code pays fourni par la source)

Characterization and Proteomic Analysis of Plasma EVs Recovered from Healthy and Diseased Dogs with Canine Leishmaniosis

Sofia Esteves, Clara Lima, Inês Costa, Hugo Osório et autres

Dogs are highly valued companions and work animals that are susceptible to many life-threatening conditions such as canine leishmaniosis (CanL). Plasma-derived extracellular vesicles (EVs), exploited extensively in biomarker discovery, constitute a mostly untapped resource in veterinary sciences. Thus, the definition of proteins …

pt, es (code pays fourni par la source)