Feline leishmaniosis in the Mediterranean Basin: a multicenter study
Rattachement africain : it, es, gr, pt, fr, il, hk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Cats are now recognized as competent hosts for Leishmania infantum and a blood source for sand fly vectors. Although canine leishmaniosis (CanL) is endemic in Mediterranean Basin countries, large-scale epidemiological studies are lacking for feline leishmaniosis (FeL). This study aimed to assess the prevalence of L. infantum infections, associated risk factors, clinical signs, and clinicopathological abnormalities in domestic cat populations from six Mediterranean Basin countries. METHODS: From 2019 to 2022, blood and serum samples of cats (n = 2067) living in Italy (n = 300), Greece (n = 297), Portugal (n = 295), France (n = 231), Israel (n = 313), and Spain (n = 631) were collected along with animal data (i.e., age, sex, breed, housing conditions, and geographical origin), clinical signs, and laboratory blood test parameters. Cats were grouped according to their age as kittens (up to 1 year), young (older than 1 and younger than 7 years), mature (between 7 and 10 years), and senior (older than 10 years). Serum samples were tested for L. infantum by immunofluorescence antibody test (IFAT) and enzyme-linked immunosorbent assay (ELISA), and blood samples of seropositive cats were tested for L. infantum kinetoplast deoxyribonucleic acid (kDNA). Viral infection by feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) was molecularly addressed in all cats enrolled. Statistical analysis was performed to evaluate the association between the risk of L. infantum infection and independent variables, and among co-infection of L. infantum with FIV and/or FeLV, clinical signs, and clinicopathological abnormalities. RESULTS: Overall, 17.3% (358/2067) of cats scored positive for L. infantum by serological tests. Specifically, 24.7% were from Portugal, 23.2% from Greece, 16.6% from Israel, 15% from Spain, 13.3% from France, and 12.6% from Italy. Leishmania infantum DNA was detected in 15 seropositive animals. Housing condition and FIV infection proved to be risk factors for FeL. Leishmania seropositivity was significantly associated with weight loss, lymphadenomegaly, gingivostomatitis, and oral ulcers, as well as with reduced albumin and albumin/globulin ratio, increased total globulins and total proteins, leukocytosis, and thrombocytosis. CONCLUSIONS: This study provides, for the first time, a large-scale epidemiological survey on FeL and its clinical presentation, revealing that L. infantum circulates among domestic cats, especially shelter/free-roaming and FIV-infected animals, living in CanL endemic countries of the Mediterranean Basin.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Feline leishmaniosis in the Mediterranean Basin: a multicenter study
- Date Crossref
- 19/08/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Bari Aldo Moro Department of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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Universidad Complutense de Madrid pays non établi dans la noticeUniversité ou école supérieure
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University of Pisa Department of Agriculture pays non établi dans la noticeUniversité ou école supérieure
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Aristotle University of Thessaloniki pays non établi dans la noticeUniversité ou école supérieure
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Universidade do Porto pays non établi dans la noticeUniversité ou école supérieure
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École Nationale Vétérinaire de Toulouse pays non établi dans la noticeUniversité ou école supérieure
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Université Fédérale de Toulouse Midi-Pyrénées pays non établi dans la noticeUniversité ou école supérieure
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Institut National de Recherche pour l'Agriculture pays non établi dans la noticeOrganisme public
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Hebrew University of Jerusalem pays non établi dans la noticeUniversité ou école supérieure
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City University of Hong Kong Department of Veterinary Clinical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Veterinary Faculty Animal Health Department pays non établi dans la noticeUniversité ou école supérieure
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School of Veterinary Medicine Department of Infectious and Parasitic Diseases and Pathology pays non établi dans la noticeUniversité ou école supérieure
Department of Veterinary Medicine — University of Bari Aldo Moro, Universidad Complutense de Madrid et Department of Agriculture — University of Pisa, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.