Inês Costa

Proteomic Profiling Identifies MARCO in Extracellular Vesicles, as a Potential Biomarker for Leishmaniasis in HIV Co-Infection

Inês Costa, Ana Isabel Pinto, Sofia Esteves, Cátia Caldas et autres

Leishmania is an intracellular protozoan parasite that causes leishmaniasis, a disease prevalent in 97 countries. Co-infection with HIV increases susceptibility to visceral leishmaniasis (VL), accelerating HIV’s progression to AIDS. Managing VL in HIV-infected individuals is challenging due to atypical presentations and limited …

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Leishmania and HIV co-infection: first naturally Leishmania strain presenting decreased susceptibility to miltefosine, recovered from a patient in Portugal

Ana Isabel Pinto, Cátia Caldas, Nuno Santarém, Sara Luelmo et autres

In Europe, up to 70% of visceral leishmaniasis (VL) cases occurring in adults living with HIV. People living with HIV with VL co-infection often display persistent parasitemia, requiring chronic intermittent anti-Leishmania therapies. Consequently, frequent VL relapses and higher mortality rates are common …

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Characterization and Proteomic Analysis of Plasma EVs Recovered from Healthy and Diseased Dogs with Canine Leishmaniosis

Sofia Esteves, Clara Lima, Inês Costa, Hugo Osório et autres

Dogs are highly valued companions and work animals that are susceptible to many life-threatening conditions such as canine leishmaniosis (CanL). Plasma-derived extracellular vesicles (EVs), exploited extensively in biomarker discovery, constitute a mostly untapped resource in veterinary sciences. Thus, the definition of proteins …

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Leishmania Vesicle-Depleted Exoproteome: What, Why, and How?

Sofia Esteves, Inês Costa, Sara Luelmo, Nuno Santarém et autres

Leishmaniasis, a vector-borne parasitic protozoan disease, is among the most important neglected tropical diseases. In the absence of vaccines, disease management is challenging. The available chemotherapy is suboptimal, and there are growing concerns about the emergence of drug resistance. Thus, a better …

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Use of Antigen Combinations to Address Complex Leishmania-Seropositivity Patterns in Dogs Living in Canine Leishmaniosis Endemic Regions of Portugal

Carla Silva Lima, Sofia Esteves, Inês Costa, Hugo Brancal et autres

Canine leishmaniosis (CanL) is a vector-borne disease caused by Leishmania infantum. Infection in dogs can result in a disease with non-specific clinical signs or in a subclinical condition. Infection diagnosis is crucial to guide public health measures considering the zoonotic potential of …

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IL-2 and IFN-γ are biomarkers of SARS-CoV-2 specific cellular response in whole blood stimulation assays

Begoña Pérez‐Cabezas, Ricardo Jorge Teixeira Ribeiro, Inês Costa, Sofia Esteves et autres

Abstract A proper description of the immune response to SARS-CoV-2 will be critical for the assessment of protection elicited after both infection and vaccination. Uncoupled T and B cell responses have been described in acute and convalescent patients and exposed individuals. We …

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Inmunotherapy in prostate cancer.

Inês Costa, Arnulf Stenzl, Jens Bedke

Prostate cancer (PCa) is the second most commonly diagnosed cancer. Although systemic chemotherapeutic agents, such as cabazitaxel, abiraterone and enzalutamde have become available to patients over the last decade, metastatic PCa is still an incurable disease. Immunotherapy is showing great promise in …

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Molecular predictors of response to PD-1/PD-L1 inhibition in urothelial cancer

Viktoria Stühler, Jonas Bochem, Inês Costa, Tilman Todenhöfer et autres

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Biomarkers in Leishmaniasis: From Basic Research to Clinical Application

Sofia Esteves, Inês Costa, Célia G. Amorim, Nuno Santarém et autres

Leishmania is an intracellular protozoan parasite and the etiological agent of a vector-borne disease known as leishmaniasis. This neglected tropical disease exhibits high morbidity and mortality putting at risk people from multiple countries worldwide. It is endemic in 97 countries and 700,000–1 …

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Transketolase like 1 (TKTL1) expression alterations in prostate cancer tumorigenesis

Inês Costa, Jörg Hennenlotter, Viktoria Stühler, Ursula Kühs et autres

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Single-use versus reusable ureterorenoscopes for retrograde intrarenal surgery (RIRS): systematic comparative analysis of physical and optical properties in three different devices

Susanne Deininger, Luis Haberstock, Stephan Kruck, Eva Neumann et autres

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Transurethral Resection of Bladder Tumors: Next-generation Virtual Reality Training for Surgeons

Eva Neumann, Julian Kristoffer Mayer, Giorgio Ivan Russo, Bastian Amend et autres

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