T. Turner

Aberrant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced Fibrosis

Shannon E. Anderson, Lauren A. Hymel, Hongmanlin Zhang, Jay M. McKinney et autres

Volumetric muscle loss (VML) injuries result in chronic fibrosis, inflammation, and persistent functional deficits. Fibro-adipogenic progenitor (FAP) cells are a heterogeneous, muscle-resident stromal cell population that play a crucial role in muscle regeneration, but also contribute to fibrosis in muscle disease. The …

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Accelerating Oral Wound Healing Using Bilayer Biomaterial Delivery of FTY720 Immunotherapy

Afra I. Toma, Daniel C. Shah, Daniela Marta Roth, Jeremie Douglas Oliver et autres

Orofacial clefts are the most common congenital craniofacial anomaly. Adverse healing following cleft palate repair can lead to oronasal fistula (ONF), a persistent connection between the oral and nasal cavities. Although human allograft tissues are currently the gold standard for ONF repair, …

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Improving Functional Muscle Regeneration in Volumetric Muscle Loss Injuries by Shifting the Balance of Inflammatory and Pro-Resolving Lipid Mediators

T. Turner, Frank S. Pittman, Hongmanlin Zhang, Lauren A. Hymel et autres

Severe tissue loss resulting from extremity trauma, such as volumetric muscle loss (VML), poses significant clinical challenges for both general and military populations. VML disrupts the endogenous tissue repair mechanisms, resulting in acute and unresolved chronic inflammation and immune cell presence, impaired …

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Harnessing Bilayer Biomaterial Delivery of FTY720 as an Immunotherapy to Accelerate Oral Wound Healing

Afra I. Toma, Daniela Marta Roth, Jeremie Douglas Oliver, Lauren A. Hymel et autres

Orofacial clefts are the most common craniofacial congenital anomaly. Following cleft palate repair, up to 60% of surgeries have wound healing complications leading to oronasal fistula (ONF), a persistent connection between the roof of the mouth and the nasal cavity. The current …

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Identifying dysregulated immune cell subsets following volumetric muscle loss with pseudo-time trajectories

Lauren A. Hymel, Shannon E. Anderson, T. Turner, William Y. York et autres

Abstract Volumetric muscle loss (VML) results in permanent functional deficits and remains a substantial regenerative medicine challenge. A coordinated immune response is crucial for timely myofiber regeneration, however the immune response following VML has yet to be fully characterized. Here, we leveraged …

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Identifying dysregulated immune cell subsets following critical volumetric muscle loss with pseudo-time trajectories

Lauren A. Hymel, Shannon E. Anderson, T. Turner, William Y. York et autres

Abstract Volumetric muscle loss (VML) results in permanent functional deficits and remains a substantial regenerative medicine challenge. A coordinated immune response is crucial for timely myofiber regeneration, however the immune response following VML has yet to be fully characterized. Here, we leveraged …

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Nanofiber-Based Delivery of Bioactive Lipids Promotes Pro-regenerative Inflammation and Enhances Muscle Fiber Growth After Volumetric Muscle Loss

Cheryl L. San Emeterio, Lauren A. Hymel, T. Turner, Molly E. Ogle et autres

Volumetric muscle loss (VML) injuries after extremity trauma results in an important clinical challenge often associated with impaired healing, significant fibrosis, and long-term pain and functional deficits. While acute muscle injuries typically display a remarkable capacity for regeneration, critically sized VML defects …

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Dual delivery of IL-10 and AT-RvD1 from PEG hydrogels polarize immune cells towards pro-regenerative phenotypes

Caitlin Sok, Nusaiba F. Baker, Claire A. McClain, Hong Seo Lim et autres

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Harnessing lipid signaling pathways to target specialized pro-angiogenic neutrophil subsets for regenerative immunotherapy

T. Turner, Caitlin Sok, Lauren A. Hymel, FredE. Pittman et autres

To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we performed a pseudotime analysis of single-cell flow cytometry data using the spanning-tree progression analysis of density-normalized events algorithm. This enables us to view neutrophil transitional …

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Modulating local S1P receptor signaling as a regenerative immunotherapy after volumetric muscle loss injury

Lauren A. Hymel, Molly E. Ogle, Shannon E. Anderson, Cheryl L. San Emeterio et autres

Regeneration of skeletal muscle after volumetric injury is thought to be impaired by a dysregulated immune microenvironment that hinders endogenous repair mechanisms. Such defects result in fatty infiltration, tissue scarring, chronic inflammation, and debilitating functional deficits. Here, we evaluated the key cellular …

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Abstract 107: SPADE Analysis Reveals The Recruitment Of Rare Immune Cell Subtypes To Site Of Injury Following Treatment With Immunomodulatory Hydrogels

Nusaiba F. Baker, Caitlin Sok, Claire A. McClain, Hong Seo Lim et autres

Purpose - Wound care following surgical procedures involves careful management, reducing risk of infection, and maximizing tissue oxygenation. Even with new strides in biological and synthetic products, achieving adequate wound care remains an important topic of interest. In this study, we develop …

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Improving hard palate wound healing using immune modulatory autotherapies

Samir A. Ballestas, T. Turner, Archana Kamalakar, Yvonne C. Stephenson et autres

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