Jeremie D. Oliver

The Mechano-Genomic Frontier: Orchestrating Nuclear Deformation for Craniomaxillofacial Bone Regeneration

Caris M. Smith, Shawn A. Hallett, Jeremie D. Oliver

The paradigm of craniomaxillofacial (CMF) reconstruction is shifting from traditional bone grafting and biochemical adjuncts toward a nucleomechanical framework that leverages the cell nucleus as a mechanosensitive organelle. By utilizing computer-aided design and computer-aided manufacturing (CAD/CAM)-derived scaffolds with 10 µm micropillar arrays …

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Spatial Transcriptomics Maps Complement-Driven Local Cell-to-Cell Interactions During Kidney Injury

Vikram Sabapathy, Daniel Chauss, Shuqiu Zheng, Jorge L. Trujillo‐Ochoa et autres

Background: Complement components are increasingly recognized as key modulators of acute kidney injury (AKI) and tissue repair. While single-cell RNA-seq reveals extrahepatic complement transcription, it lacks spatial context, limiting insight into microenvironments where complement mediates interactions among epithelial, stromal, and immune cells. …

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Spatial transcriptomic analysis of mouse parathyroid gland cells expressing an activating variant of Gcm2

Priyanka Bolel, Jeremie D. Oliver, Fábio R. Faucz, James Iben et autres

Abstract Glial cells missing 2 (GCM2) is an essential transcription factor for the development of parathyroid glands. Germline GCM2 variants that repress or enhance transcriptional activity predispose a subset of patients to hypoparathyroidism or hyperparathyroidism, respectively. A recurrent germline heterozygous activating missense …

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Single cell spatial transcriptomics links Wnt signaling disruption to extracellular matrix development in a cleft palate model

Jeremie D. Oliver, Resmi Raju, Evan Stipano, Aye Chan Myo et autres

Abstract Despite advances in understanding the morphological disruptions that lead to defects in palate formation, the precise perturbations within the signaling microenvironment of palatal clefts remain poorly understood. To explore in greater depth the genomic basis of palatal clefts, we designed and …

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Leveraging Spatial Transcriptomics to Decode Craniofacial Development

Jeremie D. Oliver, Resmi Raju, Aye Chan Myo, Evan Stipano et autres

Understanding how intricate cellular networks and signaling pathways communicate during the formation of craniofacial tissues like the palate and tooth has been the subject of intense investigation for several decades. Both organ systems undergo patterning morphogenesis and the subsequent terminal differentiation of …

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Single Cell Spatial Transcriptomics of the Murine Embryonic Palate Links Pax9 to Patterning and Organization of Extracellular Matrix Components

Jeremie D. Oliver, Resmi Raju, Evan Stipano, Aye Chan Myo et autres

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Simultaneous intraoral vertical ramus osteotomy and high condylectomy with custom internal fixation

Jeremie D. Oliver, Gabriel Grisham, Chang min Richard Yim

Condylar hyperplasia is a rare disorder typically associated with excess bone growth presenting unilaterally causing facial asymmetry. Oftentimes, patients will present with temporomandibular joint discrepancies as well as occlusion issues. While the pathogenesis and etiology are not well understood, surgical treatment options …

Accelerating Oral Wound Healing Using Bilayer Biomaterial Delivery of FTY720 Immunotherapy

Afra I. Toma, Daniel Shah, Daniela M. Roth, Jeremie D. Oliver et autres

Orofacial clefts are the most common congenital craniofacial anomaly. Adverse healing following cleft palate repair can lead to oronasal fistula (ONF), a persistent connection between the oral and nasal cavities. Although human allograft tissues are currently the gold standard for ONF repair, …

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Spatial Transcriptomics Enables Generation of a Complement Atlas of Mouse AKI

Vikram Sabapathy, Daniel Chauss, Shuqiu Zheng, Resmi Raju et autres

Background: Kidney tubulointerstitial fibrosis plays an essential role in progressive kidney disease. Our previous studies suggest that increased expression of intracellular complement (C’) components contribute to the pathogenesis of kidney fibrosis. The identity of the C’ components that participate in this process …

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Tendon-associated gene expression precedes osteogenesis in mid-palatal suture establishment

Daniela M. Roth, Jeremie D. Oliver, Resmi Raju, James Iben et autres

Orthodontic maxillary expansion relies on intrinsic mid-palatal suture mechanobiology to induce guided osteogenesis, yet establishment of the mid-palatal suture within the continuous secondary palate and causes of maxillary insufficiency remain poorly understood. In contrast, advances in cranial suture research hold promise to …

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Editorial: Skull and craniofacial development and regeneration

Jeremie D. Oliver, Johannes W. Von den Hoff

Editorial on the Research Topic Skull and craniofacial development and regenerationCraniofacial morphogenesis involves the complex interplay of cell adhesion molecules, epigenetic regulators, transcription factors, overlapping signaling pathways, and mechanotransducive forces to coordinate the most intricate anatomy of the human body, the head …

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Spatial Transcriptomic Analysis of Pituitary Corticotroph Tumors

Jeremie D. Oliver, Fábio R. Faucz, Cameron Padilla, Charalampos S. Floudas et autres

Context: Spatial transcriptomic (ST) analysis of tumors provides a novel approach to studying gene expression along with the localization of tumor cells in their environment to uncover spatial interactions. Design: We present ST analysis of corticotroph pituitary neuroendocrine tumors (PitNETs) from formalin-fixed, …

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