Laura Rivino

SARS-CoV-2 memory response in non-hospitalised cases: immunology in the context of a population-based cohort study

Ruth E. Mitchell, Milla Kibble, Marianna Santopaolo, Emily Milodowski et autres

Background The study of non-hospitalised COVID-19 cases provides a context for improved understanding of the immune response to existing and new infections. Population-based cohorts provide a unique opportunity to do this in relation to rich longitudinal pre- and pan-pandemic data. The Avon …

gb (code pays fourni par la source)

Neutralizing antibody titers do not predict T cell response to live-attenuated orthoflaviviral vaccination in humans

Justin S. G. Ooi, Noor Zayanah Hamis, Hwee Cheng Tan, Jia Xin Yee et autres

Viral vaccine development has mostly relied on measuring neutralizing antibody responses to evaluate vaccine immunogenicity. Yet, a compelling body of evidence has now demonstrated that T cell immunity, an integral component of the adaptive immune response, also plays a critical role in …

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Dengue infection elicits skin tissue-resident and circulating CD8 + T cells associated with protection from hospitalization

Noor Zayanah Hamis, J. S. G. Ooi, Ka-Wai Cheung, Valerie Chew et autres

Dengue is spreading globally, and there is urgent need to define immune correlates of protection for this disease. Dengue infection first occurs in the skin following the bite of an infected mosquito; however, knowledge of host immune responses within this site remains …

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Metformin Treatment Modulates NK-Cell and CD4+ T-Cell Responses in Hospitalised Patients With Dengue and Overweight/Obesity

Hoa Thi My Vo, Eben Jones, Laura Rivino, See PDF

Clinical and immunometabolic profiles of overweight and obese patients with dengue: A matched cohort study

Nguyen Lam Vuong, Dong Thi Hoai Tam, Duyen Huynh Thi Le, Kieu Nguyen Tan Thanh et autres

Abstract Background Obesity is a risk factor for severe dengue, but underlying mechanisms remain unclear. This study compared clinical features, outcomes, and biomarkers between overweight/obese and healthy-weight patients with dengue infection. Methods We conducted an observational matched cohort study (2019-2022) including 75 …

vn, sg, gb (code pays fourni par la source)

Dengue infection elicits skin tissue-resident and circulating CD8 + T-cells associated with protection from hospitalization

Noor Zayanah Hamis, Justin S. G. Ooi, Ka-Wai Cheung, Valerie Chew et autres

Abstract Dengue is spreading globally and there is urgent need to define immune correlates of protection against this disease. Immune responses against dengue viruses have been studied in blood samples of dengue patients. However, dengue virus infection first occurs in the skin …

gb, sg (code pays fourni par la source)

Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight

Michaela Gregorová, Marianna Santopaolo, Lucy C. Garner, Rahma Hayati et autres

Abstract Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T and …

gb, vn (code pays fourni par la source)

Hybrid B- and T-Cell Immunity Associates With Protection Against Breakthrough Infection After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Avon Longitudinal Study of Parents and Children (ALSPAC) Participants

Holly E. Baum, Marianna Santopaolo, Ore Francis, Emily Milodowski et autres

BACKGROUND: Immunological memory to vaccination and viral infection involves the coordinated action of B and T cells; thus, integrated analysis of these 2 components is critical for understanding their respective contributions to protection against breakthrough infections (BIs) after vaccination. METHODS: We investigated …

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Impact of cryopreservation on immune cell metabolism as measured by SCENITH

Curtis Luscombe, Eben Jones, Michaela Gregorová, Nicholas P. Jones et autres

Abstract The dynamic functioning of immune cells is regulated by cellular metabolic processes, and there is growing interest in the study of immunometabolic correlates of dysfunctional immune responses. SCENITH is a novel flow cytometry-based technique that allows for ex vivo metabolic profiling …

gb (code pays fourni par la source)

SARS-CoV-2 memory response in non-hospitalised cases: immunology in the context of a population-based cohort study

Ruth E. Mitchell, Milla Kibble, Marianna Santopaolo, Emily Milodowski et autres

Background The study of non-hospitalised COVID-19 cases provides a context for improved understanding of the immune response to existing and new infections. Population-based cohorts provide a unique opportunity to do this in relation to rich longitudinal pre- and pan-pandemic data. The Avon …

gb (code pays fourni par la source)

Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight

Michaela Gregorová, Marianna Santopaolo, Lucy C. Garner, Divya Diamond et autres

Summary Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T and …

gb, vn (code pays fourni par la source)

Hybrid adaptive immunity to SARS-CoV-2 protects against breakthrough infection after COVID-19 vaccination in ALSPAC participants

Holly E. Baum, Marianna Santopaolo, Ore Francis, Emily Milowdowski et autres

SUMMARY Immunological memory to vaccination and viral infection involves coordinated action of B and T-cells, thus integrated analysis of these two components is critical for understanding their contributions to protection against breakthrough infections (BI). We investigated cellular and humoral immune responses to …

gb (code pays fourni par la source)