Accès ouvert
2026
article
OpenAlex
Ruth E. Mitchell, Milla Kibble, Marianna Santopaolo, Emily Milodowski et autres
Background The study of non-hospitalised COVID-19 cases provides a context for improved understanding of the immune response to existing and new infections. Population-based cohorts provide a unique opportunity to do this in relation to rich longitudinal pre- and pan-pandemic data. The Avon …
gb
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Accès ouvert
2025
article
OpenAlex
Michaela Gregorová, Marianna Santopaolo, Lucy C. Garner, Rahma Hayati et autres
Abstract Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T and …
gb, vn
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Holly E. Baum, Marianna Santopaolo, Ore Francis, Emily Milodowski et autres
BACKGROUND: Immunological memory to vaccination and viral infection involves the coordinated action of B and T cells; thus, integrated analysis of these 2 components is critical for understanding their respective contributions to protection against breakthrough infections (BIs) after vaccination. METHODS: We investigated …
gb, tw
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Ruth E. Mitchell, Milla Kibble, Marianna Santopaolo, Emily Milodowski et autres
Background The study of non-hospitalised COVID-19 cases provides a context for improved understanding of the immune response to existing and new infections. Population-based cohorts provide a unique opportunity to do this in relation to rich longitudinal pre- and pan-pandemic data. The Avon …
gb
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Michaela Gregorová, Marianna Santopaolo, Lucy C. Garner, Divya Diamond et autres
Summary Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T and …
gb, vn
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Holly E. Baum, Marianna Santopaolo, Ore Francis, Emily Milowdowski et autres
SUMMARY Immunological memory to vaccination and viral infection involves coordinated action of B and T-cells, thus integrated analysis of these two components is critical for understanding their contributions to protection against breakthrough infections (BI). We investigated cellular and humoral immune responses to …
gb
(code pays fourni par la source)
2024
article
OpenAlex
Ruth E. Mitchell, Milla Kibble, Marianna Santopaolo, Emily Milodowski et autres
Background: The study of non-hospitalised COVID-19 cases provides a context for improved understanding of the immune response to existing and new infections. Population-based cohorts provide a unique opportunity to do this in relation to rich longitudinal pre- and pan-pandemic data. The Avon …
gb
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Marianna Santopaolo, Michaela Gregorová, Fergus Hamilton, David Arnold et autres
Coronavirus disease-19 (COVID-19) causes immune perturbations which may persist long term, and patients frequently report ongoing symptoms for months after recovery. We assessed immune activation at 3–12 months post hospital admission in 187 samples from 63 patients with mild, moderate, or severe …
gb
(code pays fourni par la source)
Accès ouvert
2023
peer-review
OpenAlex
Marianna Santopaolo, Michaela Gregorová, Fergus Hamilton, David Arnold et autres
Prolonged CD4+ and CD8+ T-cell activation and long COVID symptoms at 3 months post hospitlization independently associate with severe COVID-19, and ongoing T-cell activation does not affect the generation and maintenance of memory T-cell and antibody responses to SARS-CoV-2.
gb
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Marianna Santopaolo, Michaela Gregorová, Fergus Hamilton, David Arnold et autres
Abstract COVID-19 causes immune perturbations which may persist long-term, and patients frequently report ongoing symptoms for months after recovery. We assessed the extent and nature of immune activation at 3 months post hospital admission in patients with mild, moderate or severe COVID-19 …
gb, sg
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Marianna Santopaolo, Niall Sullivan, Anita C. Thomas, Valeria Vincenza Alvino et autres
Background: Chronic low-grade inflammation and alterations in innate and adaptive immunity were reported in Type 2 diabetes (T2D). Here, we investigated the abundance and activation of T cells in the bone marrow (BM) of patients with T2D. We then verified the human …
gb, it
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Michaela Gregorová, Daniel James Morse, Tarcisio Brignoli, Joseph Steventon et autres
Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and …
gb
(code pays fourni par la source)