Neutralizing antibody titers do not predict T cell response to live-attenuated orthoflaviviral vaccination in humans
Rattachement africain : sg, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Viral vaccine development has mostly relied on measuring neutralizing antibody responses to evaluate vaccine immunogenicity. Yet, a compelling body of evidence has now demonstrated that T cell immunity, an integral component of the adaptive immune response, also plays a critical role in controlling acute viral infection. T cell responses however, are not routinely measured in clinical trials to assess vaccine potency. If neutralizing antibody titers were indeed statistically associated with the magnitude of vaccine-induced antigen-specific T cell responses induced by a vaccine, then arguably T cell response could be inferred directly from antibody titers, without the need for independent measurement. To test this assumption, we examined, in a cohort of adult vaccinees, both neutralizing antibody titers and T cell responses induced by the live-attenuated yellow fever vaccine (YF17D). Crucially, we found no correlation between neutralizing antibody titers and the magnitude of antigen-specific T cell responses. Consistent with this observation, transcriptional profiling revealed distinct innate immune signatures that independently correlated with B and T cell immunity, suggesting that dichotomous pathways shape humoral and cellular immune responses separately. Protein-level analysis further supported this dichotomy, showing that discrete cytokine and chemokine profiles were selectively associated with neutralizing antibody production or T cell responses. Our findings suggest that neutralizing antibody titers may not always be a reliable proxy for vaccine-induced T cell response, and highlight the need for the independent measurement of T cell immunity in vaccine studies, particularly for viral infections where the protective role of T cells has been clearly demonstrated.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neutralizing antibody titers do not predict T cell response to live-attenuated orthoflaviviral vaccination in humans
- Date Crossref
- 01/04/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Duke-NUS Medical School pays non établi dans la noticeUniversité ou école supérieure
-
SingHealth Duke-NUS Academic Medical Centre pays non établi dans la noticeÉtablissement de santé
-
University of Bristol pays non établi dans la noticeUniversité ou école supérieure
-
SingHealth pays non établi dans la noticeÉtablissement de santé
-
Program in Emerging Infectious Diseases pays non établi dans la noticeInstitution
-
School of Cellular and Molecular Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Singapore General Hospital Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
-
Saw Swee Hock School of Public Health Department of Clinical Translational Research pays non établi dans la noticeUniversité ou école supérieure
Duke-NUS Medical School, SingHealth Duke-NUS Academic Medical Centre et University of Bristol, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.