Seiichi Kagimoto

Serological cytokine signature in paediatric patients with inflammatory bowel disease impacts diagnosis

Maiko Tatsuki, Reiko Hatori, Tomoko Nakazawa, Takashi Ishige et autres

Endoscopy is a central tool for diagnosing and evaluating paediatric inflammatory bowel diseases (PIBD), but is too invasive to be frequently repeated in young children. Furthermore, it is challenging to distinguish Crohn's disease (CD) from ulcerative colitis (UC) endoscopically. This study aimed …

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A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan

Takahiro Kudo, Tohru Fujii, Shunichi Maisawa, Mika Sasaki et autres

INTRODUCTION: The incidence of early-onset inflammatory bowel disease is increasing in Japan. OBJECTIVE: This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. METHODS: This prospective survey evaluated the data of 43 patients aged <8 years who were …

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Supplementary Material for: A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan

Takahiro Kudo, MUTUE TOYOTA FUJII, Shunichi Maisawa, Mika Sasaki et autres

Introduction: The incidence of early-onset inflammatory bowel disease is increasing in Japan. Objective: This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. Methods: This prospective survey evaluated the data of 43 patients aged <8 years who were …

Infliximab for pediatric patients with ulcerative colitis: a phase 3, open-label, uncontrolled, multicenter trial in Japan

Hitoshi Tajiri, Katsuhiro Arai, Seiichi Kagimoto, Reiko Kunisaki et autres

BACKGROUND: Pediatric ulcerative colitis (UC) is typically more extensive and has a more active disease course than adult UC, and requires early treatment augmentation to achieve and maintain disease remission. The present study aimed to investigate the efficacy, safety, and pharmacokinetic profile …

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Current role of colonoscopy in infants and young children: a multicenter study

Ryusuke Nambu, Shin‐ichiro Hagiwara, Fumihiko Kakuta, Tomoko Hara et autres

BACKGROUND: To evaluate the role of colonoscopy in infants and young children and clarify the distribution of colonoscopy-requiring diseases in this age group. METHODS: Cohorts of colonoscopies performed at three children's hospitals in Japan between April 2011 and March 2016 including infants …

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Clinical, Pathologic, and Genetic Features of Neonatal Dubin-Johnson Syndrome: A Multicenter Study in Japan

Takao Togawa, Tatsuki Mizuochi, Tokio Sugiura, Hironori Kusano et autres

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Pediatric Gastroenterology and Hepatology practice at Saitama Children’s Medical Center

Itaru Iwama, Ryusuke Nambu, Tomoko Hara, Seiichi Kagimoto

Validation of severity assessment for acute pancreatitis in children

Mitsuyoshi Suzuki, Nobutomo Saito, Kei Minowa, Seiichi Kagimoto et autres

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Prostaglandin E‐major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity

Shin‐ichiro Hagiwara, Isao Okayasu, Mutsunori Fujiwara, Masaaki Matsuura et autres

OBJECTIVES: Prostaglandin E-major urinary metabolite (PGE-MUM) is a useful biomarker for adult ulcerative colitis (UC) activity. In the present study, we evaluated whether PGE-MUM can also be a biomarker of pediatric UC activity and compared its efficacy in predicting UC activity with …

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Screening of carnitine and biotin deficiencies on tandem mass spectrometry

Shin‐ichiro Hagiwara, Mitsuru Kubota, Ryusuke Nambu, Seiichi Kagimoto

BACKGROUND: It is important to assess pediatric patients for nutritional deficiency when they are receiving specific interventions, such as enteral feeding. We focused on measurement of C0 and 3-hydroxyisovalerylcarnitine (C5-OH) with tandem mass spectrometry (MS/MS), which is performed as part of the …

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Long-term Retention of Plastic Bread Bag Clip That Grips and Perforates the Colonic Mucosa

Ryusuke Nambu, Shin‐ichiro Hagiwara, Seiichi Kagimoto

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Mucosal Healing of Pediatric Simple Ulcer Treated With Infliximab and Methotrexate

Shin‐ichiro Hagiwara, Mitsuru Kubota, Ryusuke Nambu, Seiichi Kagimoto

A large single ulcer of the colon can be difficult to differentiate as a separate entity (“simple ulcer” (1–3)) or as a manifestation of intestinal Behçet disease or Crohn disease (4). A 5-year-old boy, who had been diagnosed with steroid-dependent Crohn disease, …

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