Prostaglandin E‐major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity
Rattachement africain : jp, nz. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: Prostaglandin E-major urinary metabolite (PGE-MUM) is a useful biomarker for adult ulcerative colitis (UC) activity. In the present study, we evaluated whether PGE-MUM can also be a biomarker of pediatric UC activity and compared its efficacy in predicting UC activity with that of C-reactive protein and erythrocyte sedimentation rate. METHODS: Twenty-nine pediatric patients with UC (8-18 years) and 29 healthy age- and sex-matched subjects were enrolled. UC activity was evaluated using the Pediatric Ulcerative Colitis Activity Index, highest Mayo endoscopic scoring (Mayo), and Matts grading (Matts) for histologic scoring, and the sum of Mayo (total of 6 segments) and Matts in all patients with UC. PGE-MUM levels were measured using a radioimmunoassay. RESULTS: PGE-MUM levels were elevated in endoscopically and histologically active UC patients, but not in patients with endoscopic and histologic remission or controls. PGE-MUM levels positively and significantly correlated with UC activity. PGE-MUM levels were positively correlated with Pediatric Ulcerative Colitis Activity Index (r = 0.594), highest Mayo (r = 0.462), the sum of Mayo (r = 0.694), and the sum of Matts (r = 0.613), but not with highest Matt (r = 0.352). The sum of Mayo and the sum of Matts, which reflect total colon inflammation, showed highest correlation with PGE-MUM. C-reactive protein levels did not correlate with any UC activity scores. Erythrocyte sedimentation rate exhibited correlation (r = 0.490) with the sum of Mayo only. CONCLUSIONS: PGE-MUM is a reliable biomarker that reflects both the endoscopic and histologic activity of the entire colon in pediatric UC.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prostaglandin E‐major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity
- Date Crossref
- 01/06/2017
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Saitama Children's Medical Center Division of General Pediatrics pays non établi dans la noticeÉtablissement de santé
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Kitasato University Department of Pathology pays non établi dans la noticeUniversité ou école supérieure
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Japanese Red Cross Medical Center pays non établi dans la noticeÉtablissement de santé
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Teikyo University pays non établi dans la noticeUniversité ou école supérieure
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Theranostics (New Zealand) pays non établi dans la noticeEntreprise
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Department of Clinical Pathology pays non établi dans la noticeÉtablissement de santé
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Inc Healthtec pays non établi dans la noticeEntreprise
Division of General Pediatrics — Saitama Children's Medical Center, Department of Pathology — Kitasato University et Japanese Red Cross Medical Center, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.