A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
INTRODUCTION: The incidence of early-onset inflammatory bowel disease is increasing in Japan. OBJECTIVE: This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. METHODS: This prospective survey evaluated the data of 43 patients aged <8 years who were diagnosed with inflammatory bowel disease (IBD) from the time of diagnosis to 36 months after registration. RESULTS: A total of 12 patients with Crohn's disease (CD), 21 with ulcerative colitis (UC), and 3 with unclassified IBD were enrolled. The mean disease onset age was 3 years and 7 months. Colon and anal lesions were present in 100 and 50% of patients with CD, respectively. Granulomas were detected in 5 patients (41.7%). Dietary elimination including elemental diet was performed in all patients. Eleven patients (91.7%) were in remission by initial induction therapy, and 72.7% maintained remission for 36 months. Three patients (14.3%) with UC had familial history, 71.4% had pancolitis-type UC, and 66.7% exhibited disease of moderate severity. Colectomy was performed in 4 patients (21.1%). Eighteen patients (85.7%) were in remission by initial induction therapy; however, only 15.8% maintained remission for 36 months. Anal complication was more prevalent in infantile-onset IBD than in childhood-onset IBD (p = 0.014). CONCLUSIONS: Among Japanese patients aged <8 years who were diagnosed with IBD, colitis-type disease was more common in CD and pancolitis was more common in UC. As the courses of several patients were severe, identifying primary immunodeficiency appears to be necessary to confirm background disease.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan
- Date Crossref
- 18/05/2020
- Éditeur
- S. Karger AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Juntendo University Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
-
Japan Pediatric Society pays non établi dans la noticeOrganisation à but non lucratif
-
Iwate Medical University pays non établi dans la noticeUniversité ou école supérieure
-
Mie University Department of Gastrointestinal and Pediatric Surgery pays non établi dans la noticeUniversité ou école supérieure
-
Osaka International Cancer Institute pays non établi dans la noticeStructure de recherche
-
Saitama Children's Medical Center pays non établi dans la noticeÉtablissement de santé
-
Osaka Medical and Pharmaceutical University pays non établi dans la noticeUniversité ou école supérieure
-
Morioka Children's Hospital Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
-
Pediatric IBD Epidemiological Survey Working Group pays non établi dans la noticeInstitution
-
Morioka Medical Center Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
-
Osaka Medical Center and Research Institute for Maternal and Child Health Department of Pediatric Gastroenterology and Nutrition pays non établi dans la noticeStructure de recherche
-
Saitama Prefectural Children's Hospital Department of General Physician pays non établi dans la noticeÉtablissement de santé
Department of Pediatrics — Juntendo University, Japan Pediatric Society et Iwate Medical University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.