Sooraj Baijnath

Temporal effects of LPS-induced inflammation on aortic remodelling and function

Adalayne Ramsamy, Leandrie Pienaar, Tshiamo T. Maniaki, Ashmeetha Manilall et autres

BACKGROUND: Inflammation-induced vascular remodelling and dysfunction are key contributors to the development of cardiovascular disease; however, vessel remodelling processes may vary depending on the inflammatory stimulus. This study explored how varying durations of systemic inflammation impact the molecular pathways underlying aortic remodelling. …

Afrique du Sud (code pays fourni par la source)

Deaths from suspected mothball poisoning in children

M. A. H. Dempster, Lana Erasmus, Siobhan Johnstone, Kimberleigh Storath et autres

Childhood poisoning is a significant health concern in South Africa (SA), especially in densely populated informal housing settlements where children are frequently exposed to various household poisons. Poisoning accounts for 4 - 5% of paediatric hospital admissions in SA. The most common …

Afrique du Sud (code pays fourni par la source)

Nicotinamide improves physiological outcomes in an arginine vasopressin rat model of pre-eclampsia

Rebecca Reddy, Sooraj Baijnath, Nalini Govender

Pre-eclampsia (PE) is a hypertensive disorder of pregnancy that poses a substantial risk to both maternal and fetal health, especially in low-middle-income countries. Despite advancements in pregnancy-related research, effective treatment options for PE remain limited, emphasizing the need for innovative therapeutic strategies …

Afrique du Sud (code pays fourni par la source)

Oligochitosan Conjugates of the Antimalarials Dihydroartemisinin and Lumefantrine: Synthesis, Stability, Cell Viability, and Antiplasmodial Studies

William Morwa Reagile Matshe, Sindisiwe Mvango, Rudzani Malabi, Asongwe Tantoh et autres

ABSTRACT Malaria is treatable with several combinations of drugs, the most well‐known and currently most effective being artemisinin‐based therapies. Gastrointestinal absorption of these drugs can be poor and erratic if not taken with a fatty meal. Nausea and the loss of appetite, …

Afrique du Sud, us (code pays fourni par la source)

Potential Region-Specific Neuroprotective Effects of Kynurenine Administration in Healthy Rodents Using High-Resolution Mass Spectrometry

Sandy Abujrais, Anne Simeit, Fleur Kalberg, Leandrie Pienaar et autres

High Resolution Image Download MS PowerPoint Slide The tryptophan (TRP) metabolic pathway produces kynurenine (KYN) and serotonin (5-HT). These are important molecules in the central nervous system, as KYN plays a crucial role in neuroprotection, while 5-HT impacts mood and sleep patterns. …

se, us, au, Afrique du Sud (code pays fourni par la source)

Regional Molecular Changes in Chronic Lipopolysaccharide-Induced Neuroinflammation

Leandrie Pienaar, Adalayne Ramsamy, Aletta ME. Millen, Sooraj Baijnath

Background Neuroinflammation is linked to the development of depression. Exposure to the proinflammatory endotoxin lipopolysaccharide (LPS) is associated with a depressive-like phenotype in rodents. However, acute LPS exposure may reflect sickness behavior , and thus the molecular mechanisms and neurobehavioral changes associated …

Afrique du Sud (code pays fourni par la source)

Determination of Heavy Metal Contamination in Premium and Supermarket Brands of Extruded Feline and Canine Food in the South African Market

Kerusha Kalicharan, Sooraj Baijnath, Sanil D. Singh, Thishana Singh

The recent increase in pet food recalls due to contamination and the increased risk of disease has highlighted the need for the screening of canine and feline pelleted food. Heavy metals, an often-overlooked contaminant, has been highlighted for its role in the …

Afrique du Sud (code pays fourni par la source)

Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

Yea‐Rin Lee, Ibrahim Kaya, Elin Wik, Sooraj Baijnath et autres

High Resolution Image Download MS PowerPoint Slide Multiomics analysis of single tissue sections using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) provides comprehensive molecular insights. However, optimizing tissue sample preparation for MALDI-MSI to achieve high sensitivity and reproducibility for various biomolecules, such …

se, Afrique du Sud (code pays fourni par la source)

Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats

Siluleko A. Mkhize, Refentshe Nthlane, Sanelisiwe P. Xhakaza, Peter Verhaert et autres

Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear. We investigated the acute effects of quercetin on BP, aortic mechanical properties and vascular reactivity in female Sprague-Dawley (SD) rats. Hypertension was induced using L-NAME (40 mg/kg/day). Quercetin …

Afrique du Sud, be (code pays fourni par la source)

Unravelling the neuroinflammatory links in depression: the potential of a lipopolysaccharide preclinical model

Leandrie Pienaar, Sooraj Baijnath, Aletta M. E. Millen

Neuroinflammation has emerged as a significant contributor in the development of major depressive disorder (MDD). It has been suggested that neuroinflammation may potentially be an underlying mechanism driving several other theories in the pathogenesis of this multifactorial disorder. Despite this, the exact …

Afrique du Sud (code pays fourni par la source)

Acute exposure to LPS induces cardiac dysfunction via the activation of the NLRP3 inflammasome

Tshiamo T. Maluleke, Ashmeetha Manilall, Nandi Shezi, Sooraj Baijnath et autres

Systemic inflammation contributes to left ventricular (LV) dysfunction, however the role of the NLRP3 inflammasome in LV dysfunction in acute inflammatory conditions is unclear. This study investigated the role of the NLRP3 inflammasome in acute (24 h) cardiac structural and functional changes …

Afrique du Sud (code pays fourni par la source)

The anti-hypertensive effects of Dombeya rotundifolia in an arginine vasopressin rat model of pre-eclampsia

Nalini Govender, Rebecca Reddy, Sooraj Baijnath, Sanil D. Singh et autres

Afrique du Sud, gb (code pays fourni par la source)