Aletta M. E. Millen

Metabolic implications of COVID-19 with a focus on lipid profiles and inflammatory markers

Farzahna Mohamed, Sulè Gunter, Sean Currin, Frederick J. Raal et autres

COVID-19 is associated with cardiometabolic complications, including lipid abnormalities, but its effect on lipoprotein(a) [Lp(a)] remains unclear. This pilot cohort study was conducted at an academic tertiary hospital and a primary healthcare facility (6 July-31 August 2021). It included a cross-sectional baseline …

Afrique du Sud (code pays fourni par la source)

Deaths from suspected mothball poisoning in children

M. A. H. Dempster, Lana Erasmus, Siobhan Johnstone, Kimberleigh Storath et autres

Childhood poisoning is a significant health concern in South Africa (SA), especially in densely populated informal housing settlements where children are frequently exposed to various household poisons. Poisoning accounts for 4 - 5% of paediatric hospital admissions in SA. The most common …

Afrique du Sud (code pays fourni par la source)

Predictive diagnostic models for newly diagnosed diabetes mellitus in moderate to severe COVID-19: the role of TyG Index, BMI, and inflammatory markers

Farzahna Mohamed, Sulè Gunter, Bezalem Eshetu Yirdaw, Frederick J. Raal et autres

BACKGROUND: The association between COVID-19 and newly diagnosed diabetes mellitus (DM) remains uncertain. This cross-sectional study examines the role of insulin resistance (IR) and selected inflammatory markers in COVID-19 associated newly diagnosed DM. RESEARCH DESIGN AND METHODS: A cross-sectional pilot study was …

Afrique du Sud, au (code pays fourni par la source)

MON-581 Predictive Models For New-onset Diabetes Mellitus In Covid-19: Evaluating Insulin Resistance And Inflammation

Farzahna Mohamed, Sulè Gunter, Bezalem Eshetu Yirdaw, Frederick J. Raal et autres

Abstract Disclosure: F. Mohamed: None. S. Gunter: None. B.E. Yirdaw: None. F.J. Raal: None. A.M. Millen: None. I.S. Kalla: None. Background: The association between COVID-19 and new-onset diabetes (DM) is primarily based on retrospective studies, with risk factors in low- and middle-income …

Afrique du Sud (code pays fourni par la source)

SAT-255 Metabolic Implications Of Covid-19: Exploring Lipids And Inflammation

Farzahna Mohamed, Sulè Gunter, Sean Currin, Frederick J. Raal et autres

Abstract Disclosure: F. Mohamed: None. S. Gunter: None. S. Currin: None. F.J. Raal: None. I.S. Kalla: None. A.M. Millen: None. Background: COVID-19 is associated with cardiometabolic complications, but its effect on lipoprotein(a) [Lp(a)] remains unclear. This study assessed the relationship between lipid …

Afrique du Sud (code pays fourni par la source)

Potential Region-Specific Neuroprotective Effects of Kynurenine Administration in Healthy Rodents Using High-Resolution Mass Spectrometry

Sandy Abujrais, Anne Simeit, Fleur Kalberg, Leandrie Pienaar et autres

High Resolution Image Download MS PowerPoint Slide The tryptophan (TRP) metabolic pathway produces kynurenine (KYN) and serotonin (5-HT). These are important molecules in the central nervous system, as KYN plays a crucial role in neuroprotection, while 5-HT impacts mood and sleep patterns. …

se, us, au, Afrique du Sud (code pays fourni par la source)

Metabolic Implications of COVID-19: Exploring Lipids and Inflammation

Farzahna Mohamed, Sulè Gunter, Sean Currin, Frederick J. Raal et autres

Afrique du Sud (code pays fourni par la source)

Involvement of microRNA-146a-5p, but not -155-5p and -29b-5p, in left ventricular remodeling and dysfunction in spontaneously hypertensive rats

Siluleko A. Mkhize, Sulè Gunter, Ashmeetha Manilall, Lebogang Mokotedi et autres

We investigated roles of microRNAs-146a-5p, -155-5p, and -29b-5p in development of cardiac hypertrophy and dysfunction in SHRs. We showed that miR-146a-5p expression was upregulated in SHRs and positively associated with indices of concentric LVH and diastolic dysfunction, potentially as countermechanism in response …

Afrique du Sud, au (code pays fourni par la source)

The Global Prevalence of Depression Calls for Action: A Look to the Situation and Specifics with Ketamine

Sabine Himmelseher, Chimaobi Tim Nnaji, Aletta M. E. Millen

de, Nigéria, Afrique du Sud (code pays fourni par la source)

Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats

Siluleko A. Mkhize, Refentshe Nthlane, Sanelisiwe P. Xhakaza, Peter Verhaert et autres

Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear. We investigated the acute effects of quercetin on BP, aortic mechanical properties and vascular reactivity in female Sprague-Dawley (SD) rats. Hypertension was induced using L-NAME (40 mg/kg/day). Quercetin …

Afrique du Sud, be (code pays fourni par la source)

Evaluating the CURB-65 score for in-hospital mortality prediction in COVID-19 patients: insights into dysglycaemia

Farzahna Mohamed, Brent A Prim, Jarrod Zamparini, Aletta M. E. Millen et autres

Introduction: While the CURB-65 score predicts mortality in community-acquired pneumonia (CAP), its performance in COVID-19 CAP is suboptimal. Hyperglycaemia correlates with an increased mortality in COVID-19. This analysis aims to enhance predictive accuracy for in-hospital mortality among COVID-19 patients by augmenting the …

Afrique du Sud (code pays fourni par la source)

Unravelling the neuroinflammatory links in depression: the potential of a lipopolysaccharide preclinical model

Leandrie Pienaar, Sooraj Baijnath, Aletta M. E. Millen

Neuroinflammation has emerged as a significant contributor in the development of major depressive disorder (MDD). It has been suggested that neuroinflammation may potentially be an underlying mechanism driving several other theories in the pathogenesis of this multifactorial disorder. Despite this, the exact …

Afrique du Sud (code pays fourni par la source)