Peter D. E. M. Verhaert

Revealing Hidden Variables in DESI-Based Spatial Metabolomics: Solvent Composition and Tissue Type as Critical Drivers

Marco Giampà, Peter D. E. M. Verhaert, Jan Claereboudt, Emmanuelle Claude et autres

In the development of a desorption electrospray ionization (DESI) workflow for spatial metabolomics, we investigated the impact of two commonly used solvent systems, 90% acetonitrile (ACN) and 90% methanol (MeOH), on the spatial metabolomic profiling of various murine tissues. The performance of …

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Editorial: Navigating the microbial landscape: integrating mass spectrometry imaging and other multimodal imaging approaches for spatially resolved microbial studies

Michael D. Tuck, Maureen Feucherolles, Peter D. E. M. Verhaert

contributions that advance precisely this capacity, uniting mass spectrometry imaging (MSI) and complementary multimodal imaging approaches in service of spatially resolved microbial science.The four articles assembled here span the breadth of this emerging field, from foundational method development to clinical application. Situating …

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345. CHARACTERISING THE NEUROPEPTIDE LANDSCAPE OF THE POSTMORTEM HUMAN ORBITOFRONTAL CORTEX IN HEALTH, FOLLOWING SEVERE CHILDHOOD ADVERSITY AND IN PSYCHOPATHOLOGY

Katrina Z. Edmond, Deepak Kaul, Amber R. Curry, Tasneem Ahsan et autres

Abstract Background Neuropeptides are a diverse class (>100 members) of endogenous neurotransmitters. They are understood to be strongly influenced by psychological stress, specifically glucocorticoids like cortisol, with evidence of (mal)adaptation across several phenotypes of psychiatric illness. While it is hypothesised that changes …

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1577 Recent Advances in Mass Spectrometry Histochemistry Analysis of FFPE Biobanked Tissues — Close to the Holy Grail in Histopathology?

Peter D. E. M. Verhaert, Gilles Frache, Marthe Verhaert, Dietmar Rudolf Thal et autres

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Spatial Atmospheric Pressure MALDI HRMS Analysis of Histological Sections of FFPE Samples Reveals a Unique Subset of the Metabolome

Gilles Frache, David C. Muddiman, Simona Ospitalieri, Dietmar Rudolf Thal et autres

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Direct Colony Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Assay for Targeted Operon Metabolite Analysis

Nivedita Bhattacharya, Deepanwita Banerjee, Ciaran O’Connor, Dharmeshkumar S. Parmar et autres

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Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats

Siluleko A. Mkhize, Refentshe Nthlane, Sanelisiwe P. Xhakaza, Peter D. E. M. Verhaert et autres

Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear. We investigated the acute effects of quercetin on BP, aortic mechanical properties and vascular reactivity in female Sprague-Dawley (SD) rats. Hypertension was induced using L-NAME (40 mg/kg/day). Quercetin …

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High Resolution Mass Spectrometry of Cystine-Containing Neuropeptides in Histological Sections of Human FFPE Tissue Banks

Peter D. E. M. Verhaert, Gilles Frache, Dhaka Ram Bhandari, Luuk Van Oosten et autres

Using our earlier developed protocol, mass spectrometry imaging of small endogenous peptides (and a selection of small metabolites) can be successfully performed directly in tissue sections of formaldehyde-fixed paraffin-embedded (FFPE) samples, such as those available in Homo sapiens biobanks. In analogy with …

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HistoSnap: A Novel Software Tool to Extract m/z-Specific Images from Large MSHC Datasets

Kenneth Verheggen, Nivedita Bhattacharya, Marthe Verhaert, Bram Goossens et autres

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MS1-Based Data Analysis Approaches for FFPE Tissue Imaging of Endogenous Peptide Ions by Mass Spectrometry Histochemistry (MSHC)

Nivedita Bhattacharya, Konstantin O. Nagornov, Kenneth Verheggen, Marthe Verhaert et autres

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Spatially Resolved Neuropeptide Characterization from Neuropathological Formalin-Fixed, Paraffin-Embedded Tissue Sections by a Combination of Imaging MALDI FT-ICR Mass Spectrometry Histochemistry and Liquid Extraction Surface Analysis-Trapped Ion Mobility Spectrometry-Tandem Mass Spectrometry

Yarixa L. Cintron-Diaz, Mario Gomez-Hernandez, Marthe M. H. A. Verhaert, Peter D. E. M. Verhaert et autres

To make the vast collections of well-documented human clinical samples archived in biobanks accessible for mass spectrometry imaging (MSI), recent developments have focused on the label-free top-down MS analysis of neuropeptides in sections of formalin-fixed, paraffin-embedded (FFPE) tissues. In analogy to immunohistochemistry …

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The 33rd International Tandem Mass Spectrometry Workshop, Lake Louise, Alberta, Canada

Lars Konermann, I. Jonathan Amster, Jeffrey C. Smith, Peter D. E. M. Verhaert

ADVERTISEMENT RETURN TO ISSUEPREVConference ReviewNEXTThe 33rd International Tandem Mass Spectrometry Workshop, Lake Louise, Alberta, CanadaLars Konermann*Lars KonermannDepartment of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada*E-mail: [email protected]More by Lars Konermannhttps://orcid.org/0000-0002-5283-3165, I. Jonathan AmsterI. Jonathan AmsterDepartment of Chemistry, University …

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