Accès ouvert
2025
article
OpenAlex
Refentshe Nthlane, Karine D. Scheuermaier, Siluleko A. Mkhize, Frédéric S. Michel
Postmenopausal shift workers face increased cardiometabolic risk due to estrogen decline and shift work–induced circadian misalignment. Yet, their combined effects remain poorly understood, especially in hypertensive individuals. This study investigated whether circadian misalignment worsens cardiometabolic parameters in a hypertensive ovariectomized rat model. …
Afrique du Sud
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Siluleko A. Mkhize, Sulè Gunter, Ashmeetha Manilall, Lebogang P. Mokotedi et autres
We investigated roles of microRNAs-146a-5p, -155-5p, and -29b-5p in development of cardiac hypertrophy and dysfunction in SHRs. We showed that miR-146a-5p expression was upregulated in SHRs and positively associated with indices of concentric LVH and diastolic dysfunction, potentially as countermechanism in response …
Afrique du Sud, au
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Siluleko A. Mkhize, Refentshe Nthlane, Sanelisiwe P. Xhakaza, Peter D. E. M. Verhaert et autres
Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear. We investigated the acute effects of quercetin on BP, aortic mechanical properties and vascular reactivity in female Sprague-Dawley (SD) rats. Hypertension was induced using L-NAME (40 mg/kg/day). Quercetin …
Afrique du Sud, be
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Siluleko A. Mkhize, Ashmeetha Manilall, Sulè Gunter, Lebogang P. Mokotedi et autres
Background: MicroRNAs have been implicated in the pathogenesis of cardiovascular disease. However, the contribution of microRNAs remain poorly understood in the context of hypertensive cardiac pathology. Aim: We investigated the role of miR-146a-5p, -155-5p, and -29b-5p in the development of cardiac hypertrophy …
Afrique du Sud, au
(code pays fourni par la source)