Accès ouvert
2025
article
OpenAlex
Claire Tinel, Alexis Varin, Dany Anglicheau, Jasper Callemeyn et autres
INTRODUCTION: Understanding the complexity of pathways involved in allograft injuries after solid organ transplantation is essential for precise definitions of rejection subtypes and improved overall outcomes. High throughput technologies and the recently available computational methods make it now possible to address such …
fr, be, de
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Accès ouvert
2024
article
OpenAlex
Claire Tinel, Virginia Sauvaget, Laïla Aouni, Baptiste Lamarthée et autres
In kidney transplant recipients, urine CXCL9 and CXCL10 (uCXCL9/10) chemokines have reached a sufficiently high level of evidence to be recommended by the European Society of Organ Transplantation for the monitoring of immune quiescence. To assess the risk of acute rejection (AR), …
fr
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Claire Tinel, Alexis Varin, Dany Anglicheau, Jasper Callemeyn et autres
Abstract Identifying biomarkers in kidney transplant patients is essential for early detection of rejection, personalized treatment and improved overall outcomes. It improves our ability to monitor the health of the transplanted organ and tailor interventions to the specific needs of each patient. …
be, fr, de, us
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Accès ouvert
2023
article
OpenAlex
Elisabet Van Loon, Claire Tinel, Henriëtte de Loor, Xavier Bossuyt et autres
RATIONALE & OBJECTIVE: Prior studies have demonstrated the diagnostic potential of urinary chemokines C-X-C motif ligand 9 (CXCL9) and CXCL10 for kidney transplant rejection. However, their benefit in addition to clinical information has not been demonstrated. We evaluated the diagnostic performance for …
be, fr
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Claire Tinel, Virginia Sauvaget, Laïla Aouni, Baptiste Lamarthée et autres
ABSTRACT Background For kidney transplant recipients, assessing non-invasively the individualized risk of acute rejection is one of the most unmet need. Urinary chemokines are one of the short-term most promising biomarkers, because of their simple and low-cost analytical method in easily accessible …
fr
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Claire Tinel, Baptiste Lamarthée, Stéphane Gazut, Elisabet Van Loon et autres
BACKGROUND: Increasing evidence suggest that microRNAs are involved in the physiopathology of acute or chronic renal disease. In kidney transplantation, as key regulators of cellular homeostasis, microRNAs may be involved in the regulation of immune cell function and the allograft response. Here, …
fr, be, de
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Claire Tinel, Baptiste Lamarthée, Jasper Callemeyn, Elisabet Van Loon et autres
In solid-organ transplantation, microRNAs (miRNAs) have emerged as key players in the regulation of allograft cells function in response to injury. To gain insight into the role of miRNAs in antibody-mediated rejection, a rejection phenotype histologically defined by microvascular inflammation, kidney allograft …
fr, be, de
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Claire Tinel, Agathe Vermorel, Daniela Picciotto, Lise Morin et autres
BK virus (BKV) replication increases urinary chemokine C-X-C motif ligand 10 (uCXCL10) levels in kidney transplant recipients (KTRs). Here, we investigated uCXCL10 levels across different stages of BKV replication as a prognostic and predictive marker for functional decline in KTRs after BKV-DNAemia. …
fr, be
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Claire Tinel, Arnaud Devresse, Agathe Vermorel, Virginia Sauvaget et autres
The urinary chemokines CXCL9 and CXCL10 are promising noninvasive diagnostic markers of acute rejection (AR) in kidney recipients, but their levels might be confounded by urinary tract infection (UTI) and BK virus (BKV) reactivation. Multiparametric model development and validation addressed these confounding …
fr, be, de
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Lucile Amrouche, Sylvaine You, Virginia Sauvaget, Victoria Manda et autres
Abstract MicroRNAs (miRNAs) play an important role in the kidneys under physiological and pathological conditions, but their role in immune glomerulonephritis is unclear. miR-146a has been identified as a key player in innate immunity and inflammatory responses, and in the kidney, this …
fr
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Accès ouvert
2017
article
OpenAlex
Évangéline Pillebout, Agnès Jamin, Hamza Ayari, Pierre Housset et autres
Henoch-Schönlein purpura is a systemic vasculitis characterized by IgA deposits, which target the skin, joints, and kidneys, among other organs. In children, prognosis is often good but little is known about biomarkers of pediatric nephritis. We hypothesized that biological markers, including cytokines, …
fr
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Accès ouvert
2017
article
OpenAlex
Laureline Berthelot, Agnès Jamin, Denis Viglietti, Jonathan Chemouny et autres
Background: Henoch-Schönlein purpura, more recently renamed immunoglobulin A vasculitis (IgAV), is a systemic vasculitis characterized by IgA deposits. The current markers used to assess IgAV inaccurately evaluate the risk of nephritis occurrence and its long-term outcomes. The current study assessed biomarkers of …
fr, us, cn, it, be
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