Lu Zhou

Clinical value of blood circulating tumor RNA (ctRNA) in liquid biopsy of lung cancer: a narrative review

Lei Zhu, Longjun Xian, Lu Zhou, Min Yi et autres

Background and Objective: Lung cancer remains a major global health challenge, with substantial incidence rates and the highest cancer-related mortality. Liquid biopsy based on circulating tumor DNA (ctDNA) has been widely used in lung cancer diagnosis, monitoring, and treatment guidance. However, its …

cn (code pays fourni par la source)

Phase Transformation Accompanied by Evolution of Internal Stress and the Coupling Mechanism of Chemical‐Mechanical Degradation in Single‐Crystal NiRich Cathodes

Yun Liu, Xinming Fan, Gaoqiang Mao, Shuang Zhou et autres

ABSTRACT Operating LiNi x Co y Mn 1‐x‐y O 2 (NCM, x ≥ 0.92) cathodes at high temperature/voltages (≥4.3 V or 45°C) to achieve high capacity inevitably leads to accelerated capacity fade. Despite extensive research into cycling behaviour under various cut‐off voltage …

cn (code pays fourni par la source)

Gut microbiota-derived lysine phenylacetylation impairs mitochondrial function and is alleviated by SIRT3

Wei Du, Jun‐Yu Xu, Yufeng Li, Mingya Zhang et autres

cn, ca (code pays fourni par la source)

Tertiary Lymphoid Structure: A Potential Therapeutic Target Affecting Immune Response in Autoimmune Diseases

Yanni Li, Rongrong Zheng, Xiaoxuan Wei, Hongyu Chu et autres

cn (code pays fourni par la source)

Discovery of a Covalent Inhibitor Targeting the PHGDH Dimer Interface with Antitumor Efficacy

Lei Feng, Liu Y, Yiwei Zhang, Zhongjiao Fan et autres

Protein oligomerization is functionally essential for many enzymes, yet small-molecule strategies that directly target dimer interfaces remain challenging. Cysteine residues at protein dimer interfaces offer chemically addressable sites for modulating oligomeric assembly. Here, we used covalent DNA-encoded chemical library (CoDEL) screening to …

cn, pl, kr, th (code pays fourni par la source)

Design, Synthesis, and Evaluation of Phenylpyrrole Derivatives as Small-Molecule Activators of BAX

Wei Cai, Zuo Li, Yang Gu, Chenyang Qiu et autres

Small-molecule BAX activators can trigger intrinsic apoptosis directly and thus hold unique potential as a new class of anticancer therapy. Current arsenal of known BAX activators is very limited. In this work, we first identified an active hit with micromolar binding affinity …

cn, jp (code pays fourni par la source)

Discovery of 1-(Azetidin-3-ylmethyl)-1 H -benzo[ d ]imidazole Derivatives as Efficient GSTP1 Inhibitors for Gastric Cancer Treatment via Warhead Removal Strategy

Wenhao Xie, Yuehong Chen, Lulu Jiang, Xinyuan Wu et autres

Gastric cancer is commonly diagnosed at advanced stages and frequently develops multidrug resistance (MDR). Clinical evidence highlights the overexpression of glutathione S-transferase pi 1 (GSTP1) in gastric cancer, which is closely associated with tumor progression and the development of MDR. However, highly …

cn, us (code pays fourni par la source)

Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform

Yiwei Zhang, Rufeng Fan, Lei Feng, Guoliang Wang et autres

High Resolution Image Download MS PowerPoint Slide DNA-encoded libraries (DELs) have emerged as an effective and efficient selection strategy for lead compound discovery in academia and industry over the past few decades. Despite recent advancements in this field, DEL remains limited by …

cn (code pays fourni par la source)

A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential

Ting Liu, Jihao Zhou, Ying Zhang, Yongcan Ma et autres

Targeting mitochondria emerges as a promising anti-leukemia strategy, yet selective mitochondrial disruption remains challenging. Here, we identified elevated mitochondrial membrane potential (MMP) as a hallmark of leukemic transformation and chemotherapy-resistant cells, prompting screening for MMP-targeting agents. Alexidine (AD), an MMP-depleting compound, demonstrated …

cn, us (code pays fourni par la source)

Live-Cell Monitoring and Omics Analysis of Liquid–Solid Transitions of Biomolecular Condensates

Asmaa M. A. S. Farrag, Koshiro Ota, Hideaki� Yoshimura, Misao Takemoto et autres

Biomolecular condensates, or so-called membraneless organelles, transition from liquid into more solid-like states over time, contributing to the development of pathological conditions. The present study proposes a simple method using photoactive yellow protein (PYP) and its specific fluorescent covalent ligands to distinguish …

jp, ru, lk, bg, es, Égypte, us, cn, pl (code pays fourni par la source)

CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity

Hao Li, Ying Xu, Yi-Min Zheng, Zian Xue et autres

cn, th (code pays fourni par la source)

Thiophosphoryl pyridinol/pyrimidinol-based probes for covalent and fluorescent sensing of intracellular Cu2+

Zhiyuan Qi, Jing Chen, Wenhao Xie, Zhibei Qu et autres

cn, jp (code pays fourni par la source)