Misao Takemoto

Large-scale organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease

Thitinee Vanichapol, Ruby Wangford, Shyla Mishra, Misao Takemoto et autres

INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the slow, progressive formation of fluid-filled cysts within the kidneys, ultimately leading to kidney failure. Despite being the most common genetic kidney disease, therapies for ADPKD are limited. Ureteric bud (UB) organoids …

nz, jp (code pays fourni par la source)

Live-Cell Monitoring and Omics Analysis of Liquid–Solid Transitions of Biomolecular Condensates

Asmaa M. A. S. Farrag, Koshiro Ota, Hideaki� Yoshimura, Misao Takemoto et autres

Biomolecular condensates, or so-called membraneless organelles, transition from liquid into more solid-like states over time, contributing to the development of pathological conditions. The present study proposes a simple method using photoactive yellow protein (PYP) and its specific fluorescent covalent ligands to distinguish …

jp, ru, lk, bg, es, Égypte, us, cn, pl (code pays fourni par la source)

High efficiency organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease

Thitinee Vanichapol, Ruby Wangford, Misao Takemoto, Motonari Uesugi et autres

ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) causes the slow, progressive formation of fluid-filled cysts within the kidney that ultimately leads to renal failure. Despite being the most common genetic kidney disease, the range of therapies for ADPKD is limited. Ureteric bud …

nz, jp (code pays fourni par la source)

Covalent Plant Natural Product that Potentiates Antitumor Immunity

Misao Takemoto, Sara Delghandi, Masahiro Abo, Keiko Yurimoto et autres

Despite the unprecedented therapeutic potential of immune checkpoint antibody therapies, their efficacy is limited partly by the dysfunction of T cells within the cancer microenvironment. Combination therapies with small molecules have also been explored, but their clinical implementation has been met with …

jp, cn (code pays fourni par la source)

Chemoproteomic Identification of Spermidine-Binding Proteins and Antitumor-Immunity Activators

Vaibhav Pal Singh, Shuhei Hirose, Misao Takemoto, Asmaa M. A. S. Farrag et autres

Cancer immune therapies, particularly programmed cell death protein 1 (PD-1) blockade immunotherapy, falter in aged individuals due to compromised T-cell immunity. Spermidine, a biogenic polyamine that declines along with aging, shows promise in restoring antitumor immunity by enhancing mitochondrial fatty acid oxidation …

jp (code pays fourni par la source)

Non-genetic cell-surface modification with a self-assembling molecular glue

Hayase Hakariya, Ippei Takashima, Misao Takemoto, Naotaka Noda et autres

This report describes the development of a non-genetic cell-surface modification method, in which a self-assembling small molecule is combined with Halo-tag proteins. Cell-surface functionalization with cancer-linked extracellular proteins led to enhanced cell motility, angiogenesis, and immune shielding of the cells, paving the …

jp, es, us, cn (code pays fourni par la source)

Correction to: Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Fumiaki Nakamura, Norio Kudo, Yuki Tomachi, Akiko Nakata et autres

jp, nl (code pays fourni par la source)

Halistanol sulfates I and J, new SIRT1–3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Fumiaki Nakamura, Norio Kudo, Yuki Tomachi, Akiko Nakata et autres

jp, nl (code pays fourni par la source)

The novel activation-induced deoxycytidine deaminase (AID) mutants, AIDv and AIDvΔ15 are defective in SHM and CSR

Maki Kobayashi, Misao Takemoto, Tasuku Honjo

jp (code pays fourni par la source)

Identification of 1,2,5-Oxadiazoles as a New Class of SENP2 Inhibitors Using Structure Based Virtual Screening

Ashutosh Kumar, Akihiro Ito, Misao Takemoto, Minoru Yoshida et autres

Small ubiquitin like modifier (SUMO) specific proteases (SENPs) are cysteine proteases that carry out the proteolytic processing of SUMO from its pro form as well as the deconjugation of SUMO from substrate proteins. SENPs are attractive targets for drug discovery due to …

jp (code pays fourni par la source)

Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata

Misao Takemoto, Yumi Kawamura, Mikako Hirohama, Yuki Yamaguchi et autres

jp (code pays fourni par la source)