2026
article
OpenAlex
Mona Sharafi, Wei Pin Teh, Jeremy B. A. Green, Paul S. Charifson et autres
The COVID-19 pandemic led to numerous initiatives to create antiviral medications and vaccines for the treatment and prevention of infections. However, the need remains for new therapies with distinct mechanisms of action from current treatment of COVID-19 infections as well as for …
us, no
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Accès ouvert
2025
article
OpenAlex
Isabella Jaen Maisonet, Mona Sharafi, Emilie J. Korchak, Andres F. Salazar‐Chaparro et autres
Ubiquitin-specific protease 7 (USP7) is a deubiquitylase essential for cell homeostasis, DNA repair, and regulation of both tumor suppressors and oncogenes. Recently, haploinsufficiency of USP7 has been associated with Hao-Fountain syndrome (HAFOUS), a rare neurodevelopmental disorder. Although a range of USP7 inhibitors …
us, ru
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Accès ouvert
2025
article
OpenAlex
Emilie J. Korchak, Mona Sharafi, Isabella Jaen Maisonet, Andres F. Salazar‐Chaparro et autres
Hao-Fountain syndrome is a rare neurodevelopmental disorder caused by mutations in the deubiquitinating enzyme Ubiquitin-Specific Protease 7 (USP7). Due to the novelty of the disease and its poorly understood molecular mechanisms, treatments for the syndrome are currently lacking. This study examines the …
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Accès ouvert
2025
preprint
OpenAlex
Emilie J. Korchak, Mona Sharafi, Isabella Jaen Maisonet, Pilar Caro et autres
Hao-Fountain syndrome is a rare neurodevelopmental disorder caused by mutations in the de-ubiquitinating enzyme USP7 (Ubiquitin Specific Protease 7). Due to the novelty of the disease and its poorly understood molecular mechanisms, treatments for the syndrome are currently lacking. This study examines …
us, de
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Isabella Jaen Maisonet, Mona Sharafi, Emilie J. Korchak, Andres F. Salazar‐Chaparro et autres
Ubiquitin-specific protease 7 (USP7) is a deubiquitylase essential for cell homeostasis, DNA repair, and regulation of both tumor suppressors and oncogenes. Inactivating USP7 mutations have been associated with Hao-Fountain Syndrome (HAFOUS), a rare neurodevelopmental disorder. Although a range of USP7 inhibitors have …
us
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Accès ouvert
2024
article
OpenAlex
Scott B. Ficarro, Zachary H Marto, Nicholas M. Girardi, De‐Yao Deng et autres
Target-based screening of covalent fragment libraries with mass spectrometry has emerged as a powerful strategy to identify chemical starting points for small molecule inhibitors or find new binding pockets on proteins of interest. These libraries span diverse chemical space with a modest …
us
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Accès ouvert
2023
article
OpenAlex
Elizabeth Corteselli, Mona Sharafi, Robert J. Hondal, Maximilian B. MacPherson et autres
Protein-S-glutathionylation is a post-translational modification involving the conjugation of glutathione to protein thiols, which can modulate the activity and structure of key cellular proteins. Glutaredoxins (GLRX) are oxidoreductases that regulate this process by performing deglutathionylation. However, GLRX has five cysteines that are …
us
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Accès ouvert
2023
article
OpenAlex
He Zhu, Mona Sharafi, Wei Pin Teh, Ariana S. Bratt et autres
Since its introduction by Cravatt and colleagues in 1999, activity-based protein profiling (ABPP) has become widely utilized throughout academia, government, and industry laboratories to study enzymes spanning numerous gene families in a multitude of biological systems. As a variation of ABPP, competitive …
us
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2022
paratext
OpenAlex
Kyle E. Murphy, Kyle T. McKay, Mica Schenkelberg, Mona Sharafi et autres
Helical molecular springs built from chiral ladder polymers expand and contract without unfolding at room temperature. In their Communication (e202209772), Severin T. Schneebeli and co-workers show that in solution such helical ladder polymers can act like classical Hookean springs with adjustable spring …
us
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Accès ouvert
2022
article
OpenAlex
Kyle E. Murphy, Kyle T. McKay, Mica Schenkelberg, Mona Sharafi et autres
Molekulare Spiralfedern aus chiralen Leiterpolymeren expandieren und kontrahieren ohne Entfaltung bei Raumtemperatur. In ihrer Zuschrift (e202209772) zeigen Severin T. Schneebeli und Mitarbeiter, dass sich solche spiralförmigen Leiterpolymere in Lösung wie klassische Hooke′sche Federn mit einstellbaren Federkonstanten verhalten können.
us
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2022
article
OpenAlex
Kyle E. Murphy, Kyle T. McKay, Mica Schenkelberg, Mona Sharafi et autres
Abstract We report a general synthetic route toward helical ladder polymers with varying spring constants, built with chirality‐assisted synthesis (CAS). Under tension and compression, these shape‐persistent structures do not unfold, but rather stretch and compress akin classical Hookean springs. Our synthesis is …
us
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2022
article
OpenAlex
Kyle E. Murphy, Kyle T. McKay, Mica Schenkelberg, Mona Sharafi et autres
Abstract We report a general synthetic route toward helical ladder polymers with varying spring constants, built with chirality‐assisted synthesis (CAS). Under tension and compression, these shape‐persistent structures do not unfold, but rather stretch and compress akin classical Hookean springs. Our synthesis is …
us
(code pays fourni par la source)