Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.
Thomas Fox, Michael Bieler, Peter Haebel, Rodrigo Ochoa et autres
We present an easy, human-readable line notation to describe even complex peptides.
de (code pays fourni par la source)
Wenyang Li, Jennifer Y. Chen, Cheng Sun, Robert P. Sparks et autres
Chronic liver injury causes fibrosis, characterized by the formation of scar tissue resulting from excessive accumulation of extracellular matrix (ECM) proteins. Hepatic stellate cell (HSC) myofibroblasts are the primary cell type responsible for liver fibrosis, yet there are currently no therapies directed …
us, in (code pays fourni par la source)
Yang Yang, Daniela Maria dos Santos, Lorena Pantano, Rachel S. Knipe et autres
Idiopathic pulmonary fibrosis is a progressive lung disease with limited therapeutic options that is characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. YAP (Yes-associated protein) is a transcriptional coactivator that mediates mechanical and biochemical signals controlling fibroblast activation. …
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Wenyang Li, Jennifer Y. Chen, Cheng Sun, Robert P. Sparks et autres
Abstract Chronic liver injury causes fibrosis, characterized by the formation of scar tissue resulting from excessive accumulation of extracellular matrix (ECM) proteins. Hepatic stellate cell (HSC) myofibroblasts are the primary cell type responsible for liver fibrosis, yet there are currently no therapies …
us, de (code pays fourni par la source)
Daniela Maria dos Santos, Lorena Pantano, Gina Pronzati, Paula E. Grasberger et autres
Abstract Idiopathic pulmonary fibrosis is a lung disease with limited therapeutic options that is characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. YAP (Yes-associated protein) is a transcriptional coactivator that mediates mechanical and biochemical signals controlling fibroblast activation. …
us, de (code pays fourni par la source)
Michael Bieler, Michael Reutlinger, Tiago Rodrigues, Petra Schneider et autres
We present the application of machine learning models to selecting G protein-coupled receptor (GPCR)-focused compound libraries. The library design process was realized by ant colony optimization. A proprietary Boehringer-Ingelheim reference set consisting of 3519 compounds tested in dose-response assays at 11 GPCR …
de, ch, in, us (code pays fourni par la source)
Herbert Koeppen, Michael Bieler
Bernd Beck, Michael Bieler, Peter Haebel, Andreas Teckentrup et autres
CI as a discipline can look back over a 10+ year's history at BI in Germany. Aim of this chapter is to give a short overview over a number of important CI tools and systems that have been established over this period …
Michael Bieler, Herbert Koeppen
Abstract Preclinical Research The goal of chemogenomics is the exploration of all possible interactions between compounds from the chemical space and targets from the biological space. This huge interaction matrix is only sparsely filled with experimental data but can be complemented by …
de (code pays fourni par la source)
Michael Bieler, Ralf Heilker, Herbert Köppen, Gisbert Schneider
Computer-based chemogenomics approaches compare macromolecular drug targets based on their amino acid sequences or derived properties, by similarity of their ligands, or according to ligand-target interaction models. Here we present ARTS (Assay Related Target Similarity) as a quantitative index that estimates target …
de, ch (code pays fourni par la source)
Simone Kredel, Michael Werner Wolff, Silke Hobbie, Michael Bieler et autres
The monocyte chemoattractant protein 1 (MCP-1)-driven activation of CC-type chemokine receptor 2 (CCR2) is one of the early key events to induce monocyte migration toward centers of inflammation. In this work, the authors analyzed MCP-1 internalization into primary human monocytes using partially …
de (code pays fourni par la source)
Ralf Heilker, Michael Werner Wolff, Christofer S. Tautermann, Michael Bieler
de (code pays fourni par la source)
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